Featured | Mount Sinai Today

A Generous Gift to Advance Care for Children with Cancer and Blood Disease

Mar 18, 2018 | Community, Featured, Pediatrics

From left: Alan Feldman, Chairman, and Mark Zeller, Co-President and Treasurer, The Jack Martin Fund; Kenneth L. Davis, MD; Chris Mongeluzo, Co-President, The Jack Martin Fund; Lisa M. Satlin, MD; David L. Reich, MD, President and Chief Operating Officer, The Mount Sinai Hospital; and Birte Wistinghausen, MD, Medical Director of the Division of Pediatric Hematology-Oncology.

The Jack Martin Fund, a nonprofit organization that has partnered with Mount Sinai Health System for 68 years, has provided a gift to open a new pediatric cancer inpatient unit at Kravis Children’s Hospital at Mount Sinai. The benefactors, along with Mount Sinai Health System leaders, celebrated the launch of The Jack Martin Fund Inpatient Unit for Children’s Cancer and Blood Disease at a recent ribbon-cutting ceremony.

The 5,300-square-foot unit features eight private beds, including two isolation rooms with negative air pressure to protect immune-compromised children from infection, as well as a family lounge, a kitchen, and a playroom for younger children.

“This extraordinarily generous gift represents a critical step toward Mount Sinai’s goal of transforming children’s health care,” said Kenneth L. Davis, MD, President and Chief Executive Officer of the Mount Sinai Health System. “Through our alliance with Children’s Hospital of Philadelphia and the co-managed Children’s Cancer Program, we have expanded our pool of nationally recognized experts and are increasing the scope of clinical services to provide the most advanced care for children with cancer and blood disease.”

In 1988, the Division of Pediatric Hematology-Oncology was named for Jack Martin, a business executive who died of polio in 1950 after being cared for at Mount Sinai. The Jack Martin Fund was established by his family to honor his memory.

“The Jack Martin Fund Division of Pediatric Hematology-Oncology, led by new Chief Steven J. Burakoff, MD, provides exceptional care to children with cancer and blood disease, while conducting innovative research to advance our understanding and treatment of these disorders,” said Lisa Satlin, MD, Chair of Pediatrics for the Mount Sinai Health System. Dr. Burakoff also continues as Dean for Cancer Innovation at the Icahn School of Medicine at Mount Sinai and the Lillian and Henry M. Stratton Professor of Cancer Medicine as he takes on this new role. Added Dr. Satlin: “This new inpatient unit reflects our commitment to caring for children and families in a warm, nurturing environment.”

A Vision of the Future with Dennis S. Charney, MD, Dean of the Icahn School of Medicine at Mount Sinai

Mar 15, 2018 | Featured, School

This year marks the 50th anniversary of the Icahn School of Medicine at Mount Sinai. From a start-up with a first-year class of 36 students, the School is now a 1,200-student research, education, and innovation powerhouse that is ranked 13th among medical schools in the United States for National Institutes of Health funding and second among U.S. medical schools in funding per principal investigator by the Association of American Medical Colleges.

To commemorate this achievement, Dennis S. Charney, MD, Anne and Joel Ehrenkranz Dean, Icahn School of Medicine at Mount Sinai, and President for Academic Affairs, Mount Sinai Health System, was interviewed about the School’s commitment to innovation and discovery. Groundbreaking science and a firm commitment to patient care have been the School’s primary objectives for the past 50 years. Dr. Charney aims to continue this perspective into the future.

Says Dr. Charney, “It is our responsibility—the current leadership, faculty, and students—to build on that foundation so that in the next 50 years we accomplish what they did and change the lives of our patients.”

Click here to watch Dr. Charney’s full video

Chair of Geriatrics and Palliative Medicine Builds On Success in Improving Patients’ Quality of Life

Mar 6, 2018 | Featured, Your Health

R. Sean Morrison, MD, at the Wiener Family Palliative Care Unit at The Mount Sinai Hospital, which recently earned recertification by The Joint Commission.

R. Sean Morrison, MD, has been appointed Ellen and Howard C. Katz Chair of the Brookdale Department of Geriatrics and Palliative Medicine at Icahn School of Medicine at Mount Sinai. Dr. Morrison, who joined Mount Sinai in 1995, has focused on one goal throughout his career: Improving quality of life for patients and families.

“Our mission is to ensure that persons living with serious illness, multiple chronic conditions, physical disability, or cognitive impairment live as well and as long as possible,” Dr. Morrison says. “We try to establish what goals are important to our patients and help them to achieve them.”

Dr. Morrison will continue as Director of the Hertzberg Palliative Care Institute and the National Palliative Care Research Center. He succeeds Albert L. Siu, MD, who was chair of the department for 15 years. “My No. 1 objective is to build on the success of my predecessors—Drs. Robert Butler, Christine Cassel, and Albert Siu. They created the first Department of Geriatrics, and then the first integrated Department of Geriatrics and Palliative Medicine in the country, and built it into the nation’s leading academic program focused on the needs of older adults and those with serious illness.”

The Mount Sinai Hospital’s geriatrics program ranked third in the nation in the 2017–2018 U.S. News & World Report “Best Hospitals” Guide. And in February, the palliative care programs at The Mount Sinai Hospital and Mount Sinai Beth Israel earned recertification by The Joint Commission. “Mount Sinai was one of the first five hospitals to receive Advanced Certification in Palliative Care in 2011,” Dr. Morrison says. “Since that time, our teams, sites, and number of patients have multiplied considerably. Yet our services continue to offer an unwavering quality of care to seriously ill patients and their families.” He thanked the Mount Sinai Health System’s leadership for their support and thanked every team member for their dedication “to removing unnecessary suffering from the world.”

Dr. Morrison earned his MD at the University of Chicago Pritzker. He completed his residency at New York-Presbyterian Weill Cornell Medical Center and his fellowship training in geriatric medicine at the Icahn School of Medicine at Mount Sinai. In 1995, he helped found Mount Sinai’s palliative care program which started with a team of four: Dr. Morrison, Jane Morris, MS, RN, ACHPN; Judith Ahronheim, MD; and another national leader in palliative care, Diane E. Meier, MD, who is a MacArthur Fellow and the Catherine Gaisman Professor of Medical Ethics, and Professor of Geriatrics and Palliative Medicine at the Icahn School of Medicine at Mount Sinai. Dr. Meier now serves as the Director of Mount Sinai’s Center to Advance Palliative Care, an organization that Dr. Morrison collaborates closely with in disseminating innovative models of palliative care education and practice throughout the United States.

At the time that palliative care started at Mount Sinai, it was a novel team-based specialty focused on providing specialized medical care to relieve the symptoms and stress caused by the serious illness for patients and their families. It is still appropriate at any age and at any stage in a serious illness, and unlike hospice, it can be provided alongside curative and all other appropriate medical treatments. “As a result of the research, educational outreach, and clinical-care models developed at Mount Sinai, palliative care is now available in all major hospitals across the country making it one of the fastest growing specialties in American medicine,” Dr. Morrison says.

This is a crucial time for geriatrics and palliative care. “Those over age 80 are the fastest growing segment of the American population, and older adults living with serious and complex medical illness account for more than 60 percent of all health care spending,” Dr. Morrison says. “As baby boomers continue to age, all health care professionals will need to have the core knowledge and skills of geriatrics and palliative care in order to deliver high value health care.”

His goals for the Department are: to develop new models of high value clinical care to match the needs of an aging population; to create the science and evidence base that supports the care; and to train a work force that is well-prepared to care for older adults and those with serious illness. “This is the Department that created the fields of geriatrics and palliative care,” Dr. Morrison says. “My hope is that we become the Department that is responsible for completely infusing these specialties into the genome of American medicine.”

A Large-Scale Study Finds Genes Linked to Obesity

Mar 6, 2018 | Featured, Research

Ruth Loos, PhD

Diet and physical activity are not the only factors that determine how easily a person gains or loses weight. A recent study led by researchers at the Icahn School of Medicine at Mount Sinai and other institutions of the Genetic Investigation of ANthropometric Traits (GIANT) consortium has found that 13 genes may play an important role, as well.

According to the study, published in the January 2018 issue of Nature Genetics, these 13 genes carry variations associated with body mass index (BMI).

“Our study has identified genes that play a crucial role in the neuronal control of body weight,” says lead researcher Ruth Loos, PhD, Professor of Environmental Medicine and Public Health at the Icahn School of Medicine at Mount Sinai, and Director of the Genetics of Obesity and Related Metabolic Traits Program at The Charles Bronfman Institute for Personalized Medicine. “They act in the brain in pathways that may affect people’s food intake, hunger, and satiety. Individuals who inherit these genetic variations may find it harder to eat less or stop eating, compared to those who did not inherit these variations.”

The study, led by Dr. Loos and Joel Hirschhorn, MD, PhD, Concordia Professor of Pediatrics and Professor of Genetics at Boston Children’s Hospital and Harvard Medical School, and Co-director of the Broad Institute Metabolism Program, also involved the collaboration of more than 250 international research institutions that comprise the GIANT consortium.

In the past decade, researchers in the GIANT consortium have performed genome-wide screens in hundreds of thousands of individuals to identify genetic variations associated with obesity and BMI. In this new study, the consortium focused on a specific set of genetic variations that are likely to affect the function of genes and their proteins—an approach that expedited the discovery of the causal genes that affect body weight.

Genetic data from more than 700,000 individuals and 125 different studies were combined to form the largest genetic association study to date. The researchers identified a total of 14 genetic variations in 13 genes, including a “stop” variation in a gene called MC4R that causes carriers to weigh 15 pounds more, on average, than individuals who do not carry the “stop” variation.

Genes contain the information needed to make proteins. In the case of a “stop” variation, the translation from gene to protein is halted, and the protein is shorter than normal. About 1 in 5,000 individuals carries the “stop” variant in MC4R, which causes the gene not to produce the protein needed to inform the brain to stop eating. While this variant was identified two decades ago in individuals with extreme and early onset obesity, the new study shows that it also affects body weight in the general population.

Eight of the 13 genes identified were newly implicated in obesity and will require further follow-up to understand the mechanisms through which they affect body weight. By knowing the genes and the biological pathways through which they work, researchers believe they are a few steps closer to understanding why some people gain weight more easily than others, which is critical for developing effective treatments.

Genes are not the only factor in determining body weight, and it is important to be physically active and maintain a healthy diet, Dr. Loos says. However, she says, “Our study has provided new potential targets for therapeutic interventions, and may even help personalize treatment for carriers of the genetic variations.”

Remote Monitoring Improves Readmission Rates for Heart Failure Patients

Mar 6, 2018 | Featured, Research, Your Health

Sean P. Pinney, MD

Mount Sinai Heart is reducing readmissions and improving quality of life for congestive heart failure (CHF) patients with remote monitoring using new devices and apps, as well as old-fashioned compassionate care.

“We are creating a multimodal way of keeping an eye on our patients after they have left the hospital so that we can optimize their medications and keep them at home—where they want to be—rather than in the hospital,” says Sean P. Pinney, MD, Professor of Medicine (Cardiology), Icahn School of Medicine at Mount Sinai, and Director of Heart Failure and Transplantation, Mount Sinai Health System.

One of the strategies involves the ReDS™ (Remote Dielectric Sensing) system, a wearable vest made by Sensible Medical Innovations. ReDS is based on technology that allows the military to “see through walls” and find survivors in collapsed buildings. In a medical setting, a device sees through the walls of the chest, sending an electromagnetic beam through the middle lobe of the right lung, measuring the lung fluid. Based on the readings, a physician might decide to raise or lower the dosage of diuretics, or hospitalize the patient if there is an extreme overload of fluid.

Dr. Pinney’s team is participating in a randomized multicenter clinical trial of the device, sponsored by Sensible Medical, that began in September 2015 and is to be completed in June 2018. The trial will compare the readmission rates of 380 patients hospitalized for heart failure. All participants are receiving the standard care, including follow-up phone calls and outpatient visits, but one group also goes home with a ReDS vest, with their readings transmitted to care providers. Since July 2017, Mount Sinai has also been using the device in its Rapid Follow-Up Clinic for recently discharged CHF patients. “We are one of only three centers to do this, so we are in the vanguard,” Dr. Pinney says. Among the 28 patients who have used the system since July, the 30-day readmission rate was about 9 percent, compared with 22 percent for heart failure patients overall.

The CardioMEMS™ device is an implanted sensor, about as wide as a dime, that checks for increased pressure in the pulmonary artery.

Mount Sinai is an early adopter of another device, CardioMEMS™, an implanted sensor made by Abbott that checks for increased pressure in the pulmonary artery—an early indicator of worsening heart failure. A small pressure sensor is implanted in the pulmonary artery using a catheterization procedure. Sensor readings are wirelessly transmitted to a secure website for clinicians. “If the pressures rise, we increase medication, and if they come down too low, we cut back,” Dr. Pinney says. “So it gives us a feedback loop to get smarter about prescribing medicine.”

Mount Sinai is also using apps to help monitor CHF patients. One is HealthPROMISE, a system for iPhone and Android, developed by the Mount Sinai AppLab. Patients are sent home with a blood pressure cuff and a scale that send data through the app to care providers. “We can track blood pressure, weight, and the answers to simple questions about the patients’ symptoms,” Dr. Pinney says.

A pilot study by Dr. Pinney’s team found that of 52 subjects using the app, four were readmitted within 30 days of discharge. “The CHF patients had a 7 percent readmission rate compared to the national readmission rate of more than 25 percent within 30 days of discharge,” according to an abstract of the study, presented in October 2017 at the Connected Health Conference in Boston.

Another app, being developed by Dr. Pinney’s group and a startup company, RecoverLINK, is also in clinical trials. It works similarly to HealthPROMISE but asks more detailed questions about patients’ symptoms, mood, compliance with medication, and general quality of life. In addition to remote monitoring, patients also receive personalized video messages from providers.

Dr. Pinney says that heart failure patients often underestimate the severity of their condition, saying “I just have a weak heart,” when the median survival after diagnosis is about five years—“as bad as many cancers, or worse.” He sees a significant opportunity to improve the lives of CHF patients. “There is a need to identify these individuals, refer them to a heart failure center of excellence like ours at Mount Sinai, and take advantage of the pharmacologic and device therapies that now exist.”

Mount Sinai Featured in Special Report in The Wall Street Journal on the Future of Hospitals

Updated on Jun 30, 2022 | Featured, Research

Linda DeCherrie, MD

Mount Sinai Health System was featured in a recent special report in The Wall Street Journal titled “What The Hospitals Of The Future Look Like,” which spotlighted Mount Sinai’s Hospital at Home program.

“For some admissions, we can avoid the emergency department, but for most admissions like pneumonia, dehydration or a skin infection, we evaluate them in the ED and then send them home in an ambulance with an IV in place,” Linda DeCherrie, MD, clinical director of the mobile acute care team of Mount Sinai’s Hospital at Home Program, tells the Journal.

Read the article in The Wall Street Journal (requires paid subscription)

Mount Sinai’s Hospital at Home program has reduced the re-admission rate to the hospital, improved patient satisfaction outcomes, and cut the overall cost of delivering the care. Mount Sinai is working with Contessa Health.

The program is one of a number of initiatives Mount Sinai has launched focused on improving patient care.

“The goal is to care for each patient in the most appropriate setting, whether in a traditional hospital bed, an outpatient center or at home,” Kenneth L. Davis, MD, President and Chief Executive Officer of the Mount Sinai Health System, tells the Journal.

You can learn more about Mount Sinai’s Hospital at Home Program by watching this video