Hiker Reunites With Medical Students Who Came to His Aid

Matthew Fredricks with medical students, front row, from left: Aliza Green and Zina Huxley-Reicher; back row, from left: Hayley Lynch, Haley Tupper, Letitia Li, Esben Iberson, Halley Kaye-Kauderer, Matt Spindler, and Jenna Hobeika.

Miracles happen. Kindness matters. A touch of the hand can mean “everything.” Those were some of the messages that Matthew Fredricks delivered on Monday, November 27, when he was reunited with a group of students at the Icahn School of Medicine at Mount Sinai who weeks before had aided and comforted him on a hiking trail when he was having a heart attack.

“In your studies, you are going to learn the mechanics of medicine, you are going to learn all the technical terms and procedures,” Mr. Fredricks said. “But what you guys did instinctively, you can’t be taught that. You showed me compassion, and I am amazingly grateful.”

Mr. Fredricks, a kitchen designer from New City, Rockland County, was at the center of a dramatic rescue on Sunday, October 22, after he collapsed on a steep trail in Harriman State Park. Before he was lifted off the mountain by a helicopter crew—an event shown on local newscasts—he was aided by the group of medical students who were also hiking that day. Weeks later, Mr. Fredricks contacted the Icahn School of Medicine seeking a reunion with the students, and it was arranged at the Annenberg Building.

“You are incredible for making this effort,” David Muller, MD, Dean for Medical Education, and the Marietta and Charles C. Morchand Chair for Medical Education, told Mr. Fredricks. “What happened to you is really rare, but what is even more rare is that you made this effort to find every single person who helped you.”

Matthew Fredricks being lifted from the mountain trail. Courtesy of NYPD

Mr. Fredricks, 59, is an avid hiker and skier, even serving on the National Ski Patrol. A few months before the heart attack, he had what seemed to be persistent heartburn and visited his local primary care doctor and cardiologist, but a stress test and imaging were inconclusive. Mr. Fredricks had hiked the trail—a challenging 2.5-mile round trip—five times in recent months, but on October 22, he stopped near the top because he felt intense pain in his chest and arms. He called it a “miracle” that he was clearheaded enough to pick a resting spot—a flat outcropping of rock—that would be accessible to rescuers. In a second “miracle,” a Pennsylvania couple to whom he had given directions at the bottom of the trail, stopped to ask if he had made it to the top. He told them, “I didn’t, and I’m in trouble.”

The husband called 911 on his cellphone, and then a third “miracle” occurred—the arrival of the Mount Sinai students. The couple asked if they had any medical knowledge. “They were sort of joking, I think,” said Halley Kaye-Kauderer, a second-year student. “I told them ‘Not really, but probably more than anyone else here.’ ” The nine young people are members of WildMed, a group of students interested in the specialty of wilderness medicine—providing emergency care in remote settings. They huddled around Mr. Fredricks, took his pulse, and questioned him about his condition. Letitia Li, a first-year student, folded a lightweight blue towel and put it under Mr. Fredricks’s head. (He kept it, and now wears it “as a fashion statement.”) Second-year students Zina Huxley-Reicher and Aliza Green sat on either side of him. “Aliza simply said, ‘I’m going to hold your hand.’ In that moment, it meant everything,” Mr. Fredricks said, adding that he felt a sense of calm, despite excruciating pain.

After about an hour, emergency responders arrived and sent the students on their way. Mr. Fredricks was taken to the Westchester Medical Center, where a blockage was found in his right coronary artery.

Now he is watching his diet, exercising moderately, and getting follow-up cardiac care. Mr. Fredricks is also trying to thank everyone he can, reaching out to the helicopter pilot, his hospital team, and the rescue workers. He invited the students to go skiing on the mountain he patrols, and he brought each of them a blue towel similar to the one Ms. Li gave him.

“You did the right thing,” Mr. Fredricks told the students who aided him. “Keep doing it. You are in the right place, and you are all amazing people.”

A Doctor’s Reflection: Sleepless Nights, and a Desire to Help His Beloved Puerto Rico

Gerardo Miranda- Comas, MD, Assistant Professor of Rehabilitation Medicine

Like many other Puerto Ricans, I had not slept well after September 20 when Hurricane Maria hit Puerto Rico.

In the days that followed, I joined a group of health care professionals in New York City to discuss how we could help. With the support of the New York State government, nonprofit organizations and health care institutions including Mount Sinai, and other smaller groups, I was on a plane to Puerto Rico three weeks later with volunteers from Doctors for Maria Relief, a team of physicians, nurses, nurse practitioners, and logistics personnel on a mission trip to assess, treat, and educate communities and individuals to help them manage ongoing medical issues and prevent possible disease outbreaks.

In Toa Baja, we helped in a clinic that was based in a school building, triaging patients to the appropriate service—social work, psychology, nursing, pharmacy—and providing medical evaluation for primary care, pediatrics, and rehabilitation medicine. In Caguas, we set up small clinical areas in community centers. Lastly, we were escorted to Utuado by the National Guard, who helped clear the path for us to reach several inaccessible mountain communities.

Snapshot of the devastation in Utuado

The medical necessities varied. We helped educate the communities about their increased health risks and distributed food, water, and water filters. Because of the lack of access to usual care, patients with chronic conditions were on the verge of, or had already suffered, acute exacerbations, which we treated.

Mental health issues were, and still are, major concerns, especially post-traumatic stress syndrome and depression. There was an alert for cholera, leptospirosis, Zika virus, dengue fever, and hepatitis A, among other contagious illnesses.

The devastation on the island was hard to perceive and understand before I traveled there. My trip helped me comprehend the needs of my homeland, and sadly, the severity of the damage. It will take some time for Puerto Rico to recover, but I have returned confident that it will happen.’’

By Gerardo Miranda-Comas, MD, Assistant Professor of Rehabilitation Medicine at the Icahn School of Medicine at Mount Sinai.

Hosting a Fellow From Puerto Rico

Brenda Castillo, MD

As the University of Puerto Rico Sports Medicine Fellowship program in San Juan struggled to maintain regular clinic hours after Hurricane Maria, Mount Sinai’s Department of Rehabilitation Medicine offered to host the University’s current fellow, Brenda Castillo, MD, for an elective rotation. “Dr. Castillo’s training program is my alma mater,” says Gerardo Miranda-Comas, MD, Assistant Professor of Rehabilitation Medicine and Associate Program Director of the Department’s Sports Medicine Fellowship. “When I realized that her fellowship was directly affected by the devastation, we invited her to spend some time with us.”

With the support of Joseph E. Herrera, DO, Chair and Lucy G. Moses Professor of Rehabilitation Medicine for the Mount Sinai Health System, fellowship coordinator Ana Peña, and the Graduate Medical Education office, Dr. Castillo worked a month at Mount Sinai’s sports medicine clinics evaluating patients and performing ultrasound-guided injections and spinal procedures—as well as helping to provide medical coverage at several local high school football games.

“Dr. Miranda-Comas and his entire staff allowed me to continue my training as a sports medicine fellow, and for that I am truly grateful,” says Dr. Castillo, who completed her rotation Friday, December 1, and has returned to Puerto Rico. “It was definitely an excellent hands-on learning experience for me.”

An Emergency Sight-Saving Surgery for a Patient Forced to Leave Puerto Rico

Carmen Rivera at her follow-up appointment with Jessica Lee, MD.

Carmen Rivera of Isabela, Puerto Rico, was seeing black dots in her left eye and having trouble focusing when she visited a doctor who diagnosed her with a retinal detachment and scheduled her for emergency surgery on Tuesday, September 19. As Hurricane Maria approached Puerto Rico, however, the surgery was postponed, and when the island, including the hospital where she was scheduled for surgery, was left without electricity, she faced a serious health crisis. Without immediate treatment, Ms. Rivera risked losing her central vision.

“My doctor in Puerto Rico suggested I get off the island as soon as possible to have the surgery,” recalls Ms. Rivera, whose children stepped in to help—first by driving long distances to get cellular service, and finally by reaching relatives in the Bronx who arranged for her trip to New York City. “By the time I arrived here on October 2, my vision got worse and I couldn’t see anything out of my left eye,” says Ms. Rivera.

Family members brought her to New York Eye and Ear Infirmary of Mount Sinai, where retina specialist Jessica Lee, MD, Assistant Professor of Ophthalmology, Icahn School of Medicine at Mount Sinai, performed sight-saving emergency surgery on Monday, October 9. Ms. Rivera underwent retinal detachment repair surgery, which involved placing a gas bubble into the eye to keep the retina in place. “She is recovering nicely,” Dr. Lee says a few weeks after the surgery, noting that it can take about two months for the gas bubble in the eye to dissolve, at which time vision can further improve. At a follow-up visit on Tuesday, December 5, Dr. Lee reports, “Her retina is completely attached and she is doing well.”

“There are no words to describe how grateful I am that everything fell into place so that I could be in New York City and have the surgery. I am so thankful for the excellent care I received,” says Ms. Rivera. “Regaining my vision has been amazing. If I weren’t here, I would still be waiting for the surgery.”

Leadership, faculty, and staff from the New York Eye and Ear Infirmary remain eager to help other patients from Puerto Rico. They recently partnered with Bascom Palmer Eye Institute, the Puerto Rican Society of Ophthalmology, and ophthalmologists throughout the United States to launch “Eye Care: Puerto Rico,” a program that facilitates access to eye care to evacuees in need of emergency care.

SinaInnovations Highlights Era of Discovery in Cancer

Carl H. June, MD, gives the keynote address

A keynote address by Carl H. June, MD—whose research has led to a therapy that can keep a leukemia patient cancer-free for years after a single infusion—contributed to a sense of excitement and immediacy at the sixth annual SinaInnovations conference. Cancer was the theme of the event held on Tuesday, October 17, and Wednesday, October 18, in Stern Auditorium at the Icahn School of Medicine at Mount Sinai.

A few months before the conference, the U.S. Food and Drug Administration approved a groundbreaking therapy for acute lymphoblastic leukemia based on CAR-T research by Dr. June, Professor of Immunotherapy, and Director of the Center for Cellular Immunotherapies at the University of Pennsylvania. And a second CAR-T therapy, for large B-cell lymphoma, was approved on the second day of the conference. In these treatments, a patient’s own T cells are genetically engineered so they produce a protein called a chimeric antigen receptor (CAR) that allows them to recognize and attack cancer cells. The underlying concepts date to the early 1990s, Dr. June said, but the treatments can now be produced faster and at a larger scale, helping make this a time of revolution in cancer therapeutics.

When CAR-T therapy is combined with other precision medicine, “we are really changing the ability to actually cure metastatic cancer for the first time,” Dr. June said, although the complexity of solid tumors still presents a major challenge.

Dr. June was among many internationally known physicians and researchers featured at SinaInnovations in panels and presentations on immunology, viruses, genetics, genomics, and precision medicine. The conference was opened by Dennis S. Charney, MD, Anne and, Joel Ehrenkranz Dean, Icahn School of Medicine at Mount Sinai, and President for Academic Affairs, Mount Sinai Health System, who said, “Cancer kills our patients, and we need to kill cancer. We need a road map to do that. I can assure you that Mount Sinai has made a significant commitment to be at the forefront of that mission.”

Scott L. Friedman, MD, leader of SinaInnovations, with a panel on disparities in cancer care and survivorship.

At the conference, Maura Gillison, MD, PhD, Professor of Medicine, The University of Texas MD Anderson Cancer Center, also outlined her influential research, which was the first to delineate the role of human papillomavirus (HPV) as a cause of head and neck cancer in men and cervical cancer in women, resulting in a profound shift in preventive treatment—and a decrease in those cancers.

José Baselga, MD, PhD, Physician-in-Chief of Memorial Sloan Kettering Cancer Center, delivered an address on novel therapeutics in cancer. Among other advances, Dr. Baselga said, genomic sequencing of tumors makes therapies available to patients more quickly and with more precision. “The FDA is telling us they are not going to require randomized trials for rare disorders in which you have clear clinical benefit with the targeted therapy,” he said. In such cases, Dr. Baselga said, “there is no need—and actually it could be unethical—to do randomized clinical trials.”

Ramon Parsons, MD, PhD, Ward-Coleman Chair in Cancer Research, and Director, The Tisch Cancer Institute, led a panel on personalized medicine that pointed the way forward on many fronts: using mathematical algorithms to model the effects of treatments, using noninvasive “liquid biopsies” to detect and monitor cancer, and creating shareable databases on tumors.

“We are privileged to live in an era of astounding progress in genomic diagnostics, as clinical research matches specific cancers to appropriate treatments,” Dr. Parsons said. A separate panel called for pragmatic, population-level approaches to fighting cancer, such as further decreasing the rate of smoking, and addressing life-threatening disparities in access to health care.

In closing remarks, the leader of SinaInnovations, Scott L. Friedman, MD, Dean for Therapeutic Discovery and Chief of the Division of Liver Diseases at the Icahn School of Medicine at Mount Sinai, compared the state of cancer research to a glass half-full. “There are enormous opportunities, but equally enormous challenges, in public health, in finding more effective therapies, and in the financial and regulatory domains,” Dr. Friedman said. “Yet, I think this era—even this year—will be viewed in retrospect as a major inflection point toward a new world of unique therapies that will change patients’ lives.”

Corporate sponsors for SinaInnovations included Accenture PLC; Cisco Systems; Epic; Gilead Sciences, Inc.; Hitachi Consulting; IBM; Jones Day; The Kinetix Group; Pfizer; the Louis and Rachel Rudin Foundation Inc.; and Sema4. Hackathon sponsors included Persistent Systems, Inc., and the Pershing Square Sohn Cancer Research Alliance.

 

Third Annual Mount Sinai Innovation Awards

A large and diverse group of individuals and teams from the Mount Sinai Health System were honored for their contributions to research, technology, medicine, and health care at the third annual Mount Sinai Innovation Awards ceremony, held on Monday, October 16, in conjunction with the SinaInnovations conference.

Yiannis Ioannou, PhD, Inventor of the Year, right, with Erik Lium, PhD, Senior Vice President, Mount Sinai Innovation Partners.

Yiannis Ioannou, PhD, Associate Professor, Genetics and Genomic Sciences, and Gene and Cell Medicine, Icahn School of Medicine at Mount Sinai, received the Inventor of the Year Award for work in lysosomal storage diseases. Dr. Ioannou’s work led to the first treatment for Fabry disease, in collaboration with Robert Desnick, MD, PhD, Dean for Genetics and Genomic Medicine, and the discovery of small molecules that may serve as the basis for novel therapies for the treatment of numerous lysosomal storage diseases. His work as an inventor-collaborator with Mount Sinai Innovation Partners has culminated in the launch of a new company in partnership with institutional investors. Watch the video about the Inventor of the Year

 

Winners of the Faculty Idea Prize, Hala Harony-Nicolas, PhD, left, and Lior Zangi, PhD, right, with Lakshmi A. Devi, PhD, Dean for Academic Development and Enrichment.

Hala Harony-Nicolas, PhD, and Lior Zangi, PhD, received the Faculty Idea Prize for their novel RNA-based approach to efficiently deliver neuropeptides to the brain, using modified mRNA technology. Dr. Harony-Nicolas is Assistant Professor, Psychiatry, and a Seaver Fellow at the Seaver Autism Center at the Icahn School of Medicine at Mount Sinai, and Dr. Zangi is Assistant Professor, Medicine (Cardiology), and Genetics and Genomic Sciences.

 

Janice L. Gabrilove, MD, the James F. Holland, MD Professor of Medicine and Oncological Sciences, with some of the winners of the Dean’s Healthcare System Team Science Award.

The Dean’s Healthcare System Team Science Award, established to acknowledge the importance of interdisciplinary teams in translational research, went to 13 investigators at the Center for Personalized Cancer Therapeutics. The team built a personalized “fruit fly avatar” using transgenic technology to identify and optimize candidate drug combinations for individual patient-derived tumors in an effort to provide an individualized treatment plan that best aligns with the patient’s own disease biology.

The winners were Marshall Posner, MD; Celina Su-Ping Ang, MD; Erdem Bangi, PhD; Joshua Brody, MD; Ross Cagan, PhD; Michael Donovan, MD, PhD; Matthew Galsky, MD; Sara Kim, PharmD; Krzysztof Misiukiewicz, MD, MSCR; Eric Schadt, PhD; Isaiah Selkridge; Andrew Uzilov, PhD; and Kendra Yum, PharmD.

A group of 18 innovators, including collaborators from other institutions, received the 4D Technology Development Program Award for four projects that use new technology:

  • Next-generation bandages for improved wound healing: Evren Azeloglu, PhD, and Smiti Bhattacharya, MSc, with collaborators Michael Bradley; Matthew De Santis; Roman Scicchitano; Addison Shableski; and Safakcan Tuncdemir, PhD
  • Diagnostic urine biomarker for detecting diabetic nephropathy progression: Ilse Daehn, PhD; Steven Coca, DO; Girish Nadkarni, MD; and Liping Yu
  • Advanced technology to improve the treatment and quality of life of atrial fibrillation patients: Ya-El Mandel-Portnoy, PhD, with collaborator Gregor Schwartz, PhD
  • Internet-based patient activation intervention to improve referrals for cancer screening (PAIRS): Jamilia Sly, PhD; Brittney Henry; Lina Jandorf; Sarah Miller, PsyD; and Jason Rogers.

Eight individuals received Trainee Innovation Idea Awards, which highlight innovative research ideas from the Mount Sinai trainee communities that could potentially be translated into a marketable product. They are:

  • MD and MD/PhD students Theodore Pak, Mark Finkelstein, Kathleen Li, and Suhavi Tucker: The CareTeam app for clinical protocols
  • PhD student Rayees Rahman: Rapid identification of causative pathogens of infection
  • Postdoctoral fellow Gaurav Verma, PhD: Noninvasive detection of metabolic abnormalities in brain tumors
  • House staff physician Pavis Laengvejkal, MD, with collaborator Weeraporn Srisung, MD: Cloud-based health care platform.