If You Have Torn Your ACL, Here’s What to Do

You may know someone who has torn their ACL, or you may have heard about this injury while watching sports on TV. In fact, a tear in the anterior cruciate ligament (ACL) is one of the most common knee injuries, and it can happen to professional athletes, to those exercising just for fun, or those just living their daily lives.

The ligament, located in the middle of your knee, connects the bottom of the thigh bone (femur) to the top of the shinbone (tibia).  It provides critical stability for your knee, making it important for sports performance, as well as walking down the street.

In this Q&A, orthopedic surgeon Shawn Anthony, MD, MBA, Associate Chief of Sports Medicine, explains what happens if you tear your ACL and describes treatments, including a new approach that repairs your torn ligament by regrowing your own tissue rather than removing the torn tissue and rebuilding it.

How common are ACL tears?

ACL tears happen often. A quick pivot or contact injury can cause this ligament to tear. I see patients from teens, to young adults, all the way to people in their 60s and 70s with ACL tears. It can affect professional athletes, weekend warriors, and even those who just misstep while walking down the street.

What does an ACL tear feel like?

An ACL tear is one of the more painful knee injuries at the moment it happens, when the ligament actually tears. The pain is followed by swelling, difficulty walking, and a sense of instability where your knee feels like it’s going to buckle under you. Over the first week or two after the ACL injury, the pain and swelling calms down, and patients regain their range of motion. They feel fairly normal by about three to four weeks after the injury. Patients can run straight ahead with an ACL tear, even run a marathon, with minimal to no symptoms. But they will experience a sense of instability whenever they do activities that engage the ACL—whenever they try to turn or pivot.

How do you diagnose an ACL tear?

We start with a physical exam, and if the ligament feels loose, then we follow with a magnetic resonance imaging (MRI) scan. This shows us the size and location of the tear. But there are some limitations to the information we get with an MRI, especially with partial tears.

How do you treat ACL tears?

The first step after an ACL tear is to start rehabilitation to regain range of motion and reduce swelling. Some partial ACL tears can heal just with time and physical therapy; we can usually get a sense whether this is likely based on the MRI. But patients who are active and engage in pivoting sports will choose surgical intervention to improve knee stability. There are two ways to surgically treat a torn ACL: reconstruction and repair. Both of these techniques are performed through a knee arthroscopy, or key-hole minimally invasive surgery. ACL reconstruction is the traditional approach. We remove the torn tissue and reconstruct the ACL using either the patient’s own tissue or material from a tissue bank. ACL repair, particularly using the BEAR implant, helps guide the ACL to heal itself.

How does BEAR ACL repair work?

BEAR ACL stands for bridge-enhanced ACL repair. We use a collagen scaffolding, which looks like a giant marshmallow and helps regrow the patient’s ACL. (Collagen is a protein and a fiber like structure that makes up your connective tissues.) We hydrate it with the patient’s blood, then insert it inside the knee, between the torn parts of the ligament. The BEAR implant guides the patient’s own ACL tissue as it regrows (called regeneration) and then it dissolves within two months.

With both approaches, most patients can return to normal daily activities in two to four weeks, running in about four months, and pivoting sports in about nine months. Both surgeries are effective, but clinical studies have found that patients who had the BEAR ACL repair reported that their knees feel more natural. In addition, the BEAR approach offers advantages in case the patient re-tears the ACL. Re-tearing the ACL happens in about five percent of cases, regardless of how it was treated. If a patient had a BEAR repair surgery, it is much easier to do a second surgery since BEAR does not involve harvesting the patient’s own tissue or drilling holes in the bone.

Do ACL tears lead to osteoarthritis?

After an ACL injury, about one in three patients will develop osteoarthritis, which means loss of cartilage in the knee, within 10 years of the injury. This is slightly higher in patients who have untreated ACL tears. We believe that’s due to the initial injury, the trauma to the knee cartilage when the ACL is torn. Animal studies have shown promising results of less osteoarthritis in those treated with BEAR ACL repair surgery; that is an area of ongoing research in the clinical studies of BEAR patients.

Shaping Tomorrow’s Medicine: How You Can Help Prevent Alzheimer’s Disease

The battle against Alzheimer’s disease is advancing rapidly, thanks to groundbreaking research from the Icahn School of Medicine at Mount Sinai and other institutions around the world. Where there was once a bleak landscape—where diagnosis came too late and with very limited treatment options—there is now hope for researchers, clinicians, and patients as new drugs and imaging technologies become available. With the advancement of diagnostic tools, the research community has its sights set on an even more ambitious goal: preventing or delaying Alzheimer’s disease before it ever takes hold.

“We can slow down decline and degeneration, but we haven’t yet figured out how to stop it in its tracks,” says Fanny Elahi, MD, PhD, Associate Professor of Neurology; Neuroscience; and Pathology, Molecular and Cell-Based Medicine at Icahn Mount Sinai. The focus, she explains, is now shifting toward early intervention—acting before cognitive impairment is even detected, when brain tissue can still be preserved.

“This is why I’m very excited about blood biomarkers,” Dr. Elahi continues. “We’re entering an era where, similar to early cancer detection, we can potentially change the course of Alzheimer’s disease if we catch it early.”

Dr. Elahi isn’t alone in her optimism. “We are really on the verge of revolutionizing medicine here,” agrees Mary Sano, PhD, Professor of Psychiatry and Director of the Alzheimer’s Disease Research Center (ADRC) at Icahn Mount Sinai. These emerging blood biomarkers can be a powerful tool for detecting early signs of brain degeneration, but they’re not yet ready for widespread use.

Mary Sano, PhD, left, Professor of Psychiatry and Director of the Alzheimer’s Disease Research Center, and Fanny Elahi, MD, PhD, Associate Professor of Neurology; Neuroscience; and Pathology, Molecular and Cell-Based Medicine.

“We need more data from a diverse range of people to fully realize the potential of these biomarkers,” says Dr. Sano. “The general public needs to know about these biomarkers, and how they can make them more powerful by participating in research studies.”

What are blood biomarkers and how are they linked to Alzheimer’s disease?

In the past, detecting Alzheimer’s and related degenerative diseases required invasive procedures, like spinal taps, and was typically reserved for patients already experiencing symptoms of cognitive decline. While these work-ups–or comprehensive tests– measure certain proteins, or biomarkers, that are telltale signs of the disease, they silo brain health from the rest of the body, says Dr. Elahi.

Now, researchers and physicians understand that what is present in the brain can be detected in the rest of the body, including blood, opening up new possibilities for early diagnosis. Key blood biomarkers linked to Alzheimer’s include:

  • Hyperphosphorylated tau: One hallmark of Alzheimer’s disease is amyloid beta plaque buildup in the brain, and elevated levels of hyperphosphorylated tau in the blood is predictive of amyloid beta brain accumulation. This biomarker can accelerate the diagnosis and help guide the work-up that lead to treatment decisions.
  • Neurofilament light (NfL): This structural protein found in neurons and axons is shed when axons degenerate, and is one of the earliest known biomarkers of brain degeneration for Alzheimer’s and other related dementia disorders. NfL levels can provide valuable insight into the disease’s progression
  • Glial fibrillary acidic protein (GFAP): This protein is highly expressed by specialized brain cells called astrocytes. Approved by the Food and Drug Administration as a biomarker for traumatic brain injury, several studies show that levels of GFAP are also elevated in patients with Alzheimer’s disease and related dementias.

Paving the way for preventive screening

Blood biomarkers are currently being tested as a diagnostic tool for Alzheimer’s disease, with major efforts like the Davos Alzheimer’s Collaborative leading the charge.  Mount Sinai is a key participant in these studies, which currently focus on individuals already showing symptoms.

However, researchers like Dr. Elahi are eager to expand studies to include healthy individuals, aiming to catch the disease before symptoms even appear. Mount Sinai’s ADRC is also at the forefront of this research, studying biomarkers from blood and neuroimaging to enhance early detection. However, to make these tools truly effective for widespread screening, especially in individuals who do not have symptoms, more data is needed from diverse populations.

Learn more about the Davos Alzheimer’s Collaborative project here.
To learn more about blood biomarkers and work from Dr. Elahi’s lab, click here.

“We are learning so much, but we need more participants to help use fine-tune these biomarkers,” says Dr. Sano. “We’re on the cusp of making these tools useful to clinicians and to the broader public.”

How you can help make preventive screening a reality

Participating in Alzheimer’s research is a vital step toward turning these promising biomarkers into reliable tools for prevention. Signing up for an Alzheimer’s disease research center registry is a good start, says Dr. Sano. The team at Mount Sinai will reach out to interested individuals offering various ways to participate.

Diversity in these studies is crucial.  “Different factors, like comorbidities, can influence biomarker levels, and we need to understand these nuances,” says Dr. Elahi. Historically, Alzheimer’s research has been predominantly white-centric, but the disease affects people of all backgrounds. To create effective screening tools, the research community needs participants from a wide range of medical, socioeconomic, gender, age, race, and ethnic backgrounds.

“We need to shift our thinking from treating Alzheimer’s disease to preventing it,” says Dr. Sano. This message is going to be important for people in their 30s, 40s, and 50s, so they can take appropriate steps, such as screening or adjusting lifestyle habits, to reduce or delay the risk.

“New tools, such as blood biomarkers, that push the frontier of early detection will impact what we learn about the causes of disease and eventually revolutionize treatments,” says Dr. Elahi.

How Can I Find Relief From Fall Allergies?

Many people enjoy the cool weather and colorful foliage autumn brings. But for those with fall allergies, the season also comes with watery eyes, itchy throats, and stuffy noses. Fortunately, there are ways to alleviate these symptoms and appreciate the change of season.

Rachel L. Miller, MD

In this Q&A, Rachel L. Miller, MD, Chief, Division of Clinical Immunology, and The Dr. David and Dorothy Merksamer Professor of Medicine (Allergy and Immunology), Icahn School of Medicine at Mount Sinai, explains what could be triggering your fall allergies and how to treat them.

What causes fall allergies?

The most common causes are weed pollens, especially ragweed, and outdoor molds. Ragweed is a very robust urban weed that is common in the New York City area—it grows in Central Park, along roadsides, and in sidewalk cracks, starting middle to late August through the fall. Outdoor molds, also prevalent during this time, are produced by decaying leaves and other organic matter.

How can I know if my symptoms are from fall allergies or non-allergies such as COVID-19 or a cold?

Allergies are more likely to trigger symptoms such as a stuffy nose, itchy throat, and teary eyes. If your throat is actually painful or you have a fever, that is more likely to be a virus. A cough can be caused by either.

What are the most effective over-the-counter treatments for fall allergies?

The first line of therapy is nasal steroids. Some effective over-the-counter nasal steroid sprays include:

  • Fluticasone (Flonase®)
  • Budesonide (Rhinocort®)
  • Triamcinolone (Nasacort® Allergy24HR)

These work by reducing inflammation in your nasal passages that trigger symptoms such as a runny nose.

Antihistamines also can be helpful to alleviate allergic symptoms like eye irritation and sneezing. Over-the-counter antihistamines include:

  • Oral treatments such as cetirizine (Zyrtec®) and loratadine (Claritin® and Alavert®)
  • Nasal medications such as azelastine (Astepro®)
  • Eye drop medications also with azelastine (Optivar®), ketotifen (Alaway® and Zaditor®), and olopatadine (Pataday®)

Higher strength treatments are available with prescription. An allergist can determine which options are best for your symptoms. You can also use over-the-counter sinus rinses, such as neti pots (NeilMed® and SinuCleanse®) and saline solution sprays, to cleanse your nasal passages of allergens and other particulates several times per week. Be sure to use distilled or sterilized water.

What medical interventions can reduce my symptoms?

The first step to seeking any allergy treatment is to schedule an appointment with an allergist. We can provide tests to determine if you have ragweed, mold, or other allergies. Based on the results, we may recommend certain allergy shots or prescribe daily sublinguals (under-the-tongue tablets). The latter is effective for treating ragweed allergies. For the sublingual tablet to be effective, you need to start the medication a few months in advance of allergy season and continue it during the season.

What else can I do?

In general, you want to reduce the amount of allergens you come in direct contact with. When you are outside, wear a head covering and sunglasses, so the pollen and mold spores don’t get in your hair and eyes. Take your shoes off when you are get home so you’re not tracking the allergens inside. Keep windows closed, and use an air purifier to reduce pollen and other allergens in your home. Shower and shampoo your hair before bed to remove allergens from your body and pillow.

Less Invasive Approach Is Best Option for Many Patients, Says Chief of Spine Surgery at Mount Sinai West Spine Center

Samuel Cho, MD, left, reviews a patient’s surgical plan with Brian Cho, MD, MSCR, a member of the care team.

Patients with pain in their spine or spine-related leg pain are often first counseled to try conservative treatment options like physical therapy or lifestyle modifications. However, when the pain persists, they may need surgery.

For many of these patients, an ultra-minimally invasive method called bi-portal endoscopic spine surgery is a worthwhile alternative. It is particularly useful for patients with a herniated disc, spinal stenosis (a narrowing of the spine), or spondylolisthesis (a condition in which a vertebrae moves out of place). It’s also a practical alternative to conventional open surgery—which typically involves making a larger incision—especially for frail patients and others who may not tolerate an open procedure.

“Due to a smaller incision and less disruption to the muscles and ligaments surrounding the spine, there is less pain, less bleeding, and a reduced risk of infection,” says Samuel Cho, MD, Chief of Spine Surgery, Mount Sinai West. “With endoscopic spine surgery, patients are able to get out of bed and begin physical therapy much sooner after surgery.  All of these factors lead to a shorter recovery period with low complication rates and decreased potential for long-term instability.”

Biportal endoscopic spine surgery uses two independent, exchangeable portals for viewing and working through two incisions about a quarter of an inch to a third of an inch in size. With this technique, surgeons maintain a certain distance from the bony and neural structures, which allows closer access to the target lesion through a magnified, panoramic view that supports accuracy and precision.

Through one portal, which is one of the incisions, a thin fiber-optic video camera is inserted into the body, allowing the surgeon to use one portal for viewing and the other portal, through the other incision, for working. These can be exchanged as needed to maximize the outcome of the surgery.

“By using this technique all of the normal structures are preserved,” says Dr. Cho.  “At the end of the procedure, the endoscope is removed and only a small bandage is needed to cover the incision area.”

“To date, I have performed over 50 spine surgeries using bi-portal endoscopy with very positive outcomes,” says Dr. Cho.

Others with special circumstances or special needs may also benefit from this ultra-minimally invasive approach, according to Dr. Cho.

For example, one patient had a metastatic tumor causing loss of bowel and bladder function, which is considered a surgical emergency; however conventional surgery is not recommended for patients needing chemotherapy and/or radiation due to the possibility of the closed incision reopening or infection. With endoscopic surgery, the incision is extremely small so patients can receive radiation right away after surgery. In this case, Dr. Cho performed an endoscopic procedure and the patient’s nerve function, along with bowel and bladder function, returned immediately.

As Chief of Spinal Deformity for Mount Sinai Health System, Dr. Cho sees many patients with scoliosis, a curvature of the spine. One scoliosis patient was experiencing spinal stenosis. Traditional open surgery can potentially disturb enough of the surrounding structures to make scoliosis worse following decompression surgery. Damage to surrounding structures is avoided with an endoscopic approach. This patient had a positive outcome avoided the need for a major surgery.

Need to Be Outside for Work or Play? Here’s How to Manage the Heat

When temperatures soar, especially combined with high humidity, people are at risk for heat-related illness including heat exhaustion and heat stroke.

While it’s best to avoid going outside in extreme heat, not everyone can stay inside. Whether you work outdoors or need to get in your exercise routine, there are ways to reduce your risk of developing heat illness.

Michael Redlener, MD

In this Q&A, Michael Redlener, MD, Medical Director of the Mount Sinai West Emergency Department, explains how heat can affect you and how to stay safe.

What are the risks of being active outdoors when it’s very hot?

If you are exercising or working outside, your body is working harder and your metabolism (internal process of converting food to energy) increases.  Normally, your body can regulate the internal temperature even as your metabolism increases. However, when it is hot outside, the high environmental temperature makes it harder for your body to regulate its internal temperature, putting you at a higher risk of increasing your body temperature to dangerous levels.

Who is most at risk?

People who are 65 or older, children, people who have disabilities, and people who are generally working outside or spending a lot of time outside have a higher tendency to get heat illness. People who are overweight, on certain medications, living with heart disease or mental illness, and people who drink alcohol, are all at risk. Having a sunburn also increases your risk because it reduces your ability to control your temperature through your skin’s normal mechanism.

Concerning medications, certain drugs can affect your body’s ability to process heat, so it’s important to consult your doctor if you plan on being out in the heat. The Centers for Disease Control and Prevention provides guidance on heat and medications.

What signs indicate I’m developing heat illness when being active in the heat?

There’s a range of conditions to watch for. Painful heat cramps caused by dehydration and too much sweating are usually the first sign of danger. If you experience heat cramps, stop any physical activity, move to a cooler place, drink water or a sports drink with electrolytes, and wait for the cramps to go away before you restart physical activity.

If cramps last longer than an hour, or if you are for some reason on a low sodium diet, or if you have heart problems and these symptoms continue, seek medical help. If it progresses, it becomes heat exhaustion. You will experience heavy sweating, and feel cold and clammy. You may have a fast and weak pulse, some nausea or vomiting, and muscle cramps. You will also experience general fatigue and tiredness, dizziness, possibly a headache, and you may even pass out.

If this happens to you or someone else, move to a cooler place and loosen your clothing. If possible, apply cool wet cloths to your body or get into a cool bath to reduce your body temperature. Sip water if you feel nauseous, and to make sure you’re staying hydrated. If you are vomiting and can’t stop, or if your symptoms are getting worse or lasting longer than an hour, seek medical help.

Quick Tips: To avoid dehydration, start taking sips of water or a sports drink with electrolytes before you get thirsty, and avoid sugary drinks and very cold drinks, which can make dehydration worse.

How does heat stroke differ?

The next stage after heat illness is heat stroke, the worst heat-related medical condition that can happen to you. During heat stroke, your body temperature is 103 degrees or greater. Not only will you experience a headache, dizziness, and nausea, you also become confused. You don’t know where you are, or possibly even who you are, and you can pass out. Heat stroke is an extremely dangerous condition that can lead to permanent brain injury, and even death. If you are exercising and become confused or can no longer function, or notice this happening to someone else, get to a cooler place quickly and call 911. If possible, apply cool cloths or take a cool bath to get that temperature down.

How can I change my exercise routine to reduce my risk?

Here are some things you can do to reduce your risk:

  • Limit outdoor activity as much as possible, especially during the middle of the day, the hottest period. If you need to exercise outdoors, do so in the early morning (before 10 am) or evening (after 4 pm).
  • Wear sunscreen—SPF 30 or higher.
  • Start slow and pace your activity, and slowly pick up the pace as you can tolerate.
  • Keep hydrated during and after your workout.
  • Wear loose, lightweight, light-colored clothing, which absorb less heat.

How can I stay properly hydrated?

There are a number of ways to make sure you drink enough fluids.

  • Bring a water bottle and drink more water than usual.
  • Drink sports drinks with electrolytes to maintain a balance between water and salt in your body.
  • Don’t wait until you’re thirsty to drink. Once you are thirsty, you’re already dehydrated.
  • Avoid very cold drinks, which can cause stomach cramps due to the dramatic shift in body temperature during extreme heat.
  • Avoid very sugary or alcoholic drinks, which increase dehydration.

Any other suggestions on what I can do if I work or do physical activity outdoors?

If you have to be outside during the hottest hours, have a plan about what you are going to do should you start feeling badly. If you are with someone, such as a friend or coworker, check on each other to stay hydrated and get help if medical attention is needed.

COVID-19 Cases Have Been Rising: Three Key Takeaways

If you know someone who has had to stay home because of COVID-19, you’re not alone. Cases of the virus have been rising in New York City.

However, experts say this was expected, as there was a spike in cases last summer. More important, the number of hospitalizations is below the previous spikes that have appeared regularly over the last four years, and nowhere near the highest levels recorded in 2020 and 2022.

“The good news is the peak is not as high,” says Bernard Camins, MD, MSC, Professor of Medicine (Infectious Diseases) at the Icahn School of Medicine at Mount Sinai and the Medical Director for Infection Prevention for the Mount Sinai Health System.

One thing that’s different right now is that a new vaccine is on the way, and the experts say you should plan to get that as soon as it’s available. The Food and Drug Administration approved the new vaccine on Thursday, August 22, sooner than anticipated. The new vaccine is expected to be available shortly.

Dr. Camins and Judith A. Aberg, MD, Dean of System Operations for Clinical Sciences and Chief of the Division of Infectious Diseases at Icahn Mount Sinai, who have been tracking the virus since it arrived in New York City in March of 2020, offer three key takeaways about COVID-19 and what you need to do to stay healthy.

Another summer surge, but less so: Experts believe cases tend to rise in the summer as more people get out and travel around, exposing more people to new variants. In addition, lots of people still tend to gather indoors during the summer.

Hospitalizations in New York, one of the key measures of the virus, have been rising through June and July, but they began to decline in late July, according to the New York City Department of Health and Mental Hygiene.

Health authorities have stopped tracking the number of individual cases of COVID-19 because health care providers are no longer reporting them and because so many people are testing themselves and so positive results are not officially recorded. Also, the government has stopped giving out free testing kits, so that’s discouraged some from testing. (Another measure of the growing number of cases has been the presence of the virus in wastewater, which is tracked by health authorities.)

Your best defense against a COVID-19 infection remains the same: Keep up to date with your vaccinations, consider taking steps to limit your exposure to large indoor crowds, wear a well-fitting mask at public gatherings or in tight spaces such as an airplane or subway, and talk with your health care provider if you are feeling sick.

The new variant: The latest dominant variants of the virus causing COVID-19 in New York, known as KP.3 and LB.1, do not seem to be any more worrisome than others that came before it, and existing treatments work well against it.

“We will continue to see more variants as the virus that causes COVID-19 mutates,” says Dr. Aberg, who has been seeing more cases among her patients and writing more prescriptions for antiviral medication. “You just have to accept there is always going to be a new variant.”

The time for a new vaccine is approaching: In fact, the rise of new variants is why it is important for everyone six months and older to get the new vaccine once it is available, experts say. COVID-19 vaccines typically provide protection for up to 20 weeks before their effectiveness begins to decline. Data continue to show the importance of vaccination to protect against severe outcomes of COVID-19, including hospitalization and death, according to the CDC.

To explain to her patients why getting the new vaccine is important, Dr. Aberg will often draw a simple diagram. The diagram looks like the branches of a large tree spreading out. What’s important is that the recent variants all extend off the same main branch, so a vaccine that is effective against the variant on the preceding branch will be effective against the variants that follow that branch. The latest variants stem from a different branch than the variants in 2023 that were dominant when the 2023 formulation of the COVID-19 vaccine was developed. So the vaccine you received last year will not be as effective against the most recent variants.

One other point to consider if you plan to get the new vaccine in the fall: After you get the vaccine, it takes about two weeks for the antibodies to build up in your system. So if are getting the vaccine because you are planning to take a trip or attend a large family gathering, be sure to get it at least two weeks in advance if possible.

Tips for keeping healthy:

• Those at risk for complications from respiratory infections may want to wear a more protective mask in crowded areas, such as riding the bus or subway or shopping. A surgical mask provides some protection but not as much as a higher quality N95 or KN95 mask.

• Individuals at high-risk should talk with their health care provider and have a plan for how to get antiviral medications if they become infected with COVID-19 or the flu, as these prescription medications must be taken within the first days of symptom onset. Those at high-risk include older adults, those with chronic medical conditions, such as diabetes, and those with reduced ability to fight infections, such as those being treated for some cancers.

 

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