Questions to Ask Your Doctor About HPV-Related Oral Cancer

To make an appointment with Raymond Chai, MD, call 212-844-8775.

Did you know that the human papillomavirus (HPV) can cause cancers of the oropharynx (tongue, tonsils, and back of the throat), similar to how HPV causes cervical cancer?

Most oral HPV infections can clear naturally without treatment. But if the virus persists in the system, it could incite more serious health issues, such as these cancers. Additionally, the incidence is low, with about 12,000 new cases of these HPV-associated cancers diagnosed each year in the United States, but 80 percent affect men.

Raymond Chai, MD, a head and neck surgeon at the Mount Sinai Union Square location of the Head and Neck Institute/Center of Excellence for Head and Neck Cancers, answers some frequently asked questions about oral HPV infections.

What are my options for treatment?

The two main approaches are upfront radiation treatment with chemotherapy versus a primary surgical approach.

Do you offer transoral robotic surgery (TORS)?

This technology has largely replaced traditional surgery, which typically required splitting the lip and cutting the jaw to access the tumor.

Do you have a true multidisciplinary approach to this disease?

Both surgical and non-surgical treatments should be on the table and discussed. In select cases, the use of TORS can either completely eliminate postoperative radiation, lower the dose of postoperative radiation, or eliminate the need for chemotherapy.  This may reduce the risk of long-term side effects from high-dose radiation and chemotherapy.

What is your experience level with TORS? How many cases have you performed?

Experience matters with this new technology and as with any new surgery, there is a learning curve. Even seasoned surgeons who are experts with open approaches need to have the appropriate training and experience to become proficient in performing this surgery. Robotic surgery does not have the same tactile feedback that surgeons typically rely on in performing procedures. In addition, in TORS, complex anatomy needs to be re-learned from the inside-out, since the surgeon is now operating from inside the mouth instead of outside from the neck.

What is your rate of complications, particularly bleeding?

TORS has been shown to be very safe in expert hands, with a low rate of postoperative bleeding of 2-4 percent.

What is your average length of stay for TORS patients?

Studies have demonstrated that for high-volume TORS practices, patients on average leave the hospital two days following surgery.

Do you work closely with a swallowing therapist?

Whether the treatment is radiation with chemotherapy or surgery, the best post-treatment swallowing outcomes are seen when patients are followed closely with a seasoned speech-language pathologist.

 What are your research efforts with TORS?

Across the country, investigators are actively recruiting patients in clinical trials that are using TORS as a platform for de-intensifying their cancer treatment. Mount Sinai was one of the early adopters of TORS and continues research activities related to the reduction of complications.  We are leading efforts in de-intensification with the SIRS 2.0 trial, which relies on a novel blood test evaluating circulating tumor DNA (ctDNA).  If HPV ctDNA becomes undetectable after surgery, patients are either observed without additional treatment or receive a highly de-intensified regimen of chemotherapy and radiation.

What is your protocol for follow-up care?

Nearly 100 percent of distant metastases for classic head and neck cancers related to smoking occur within the first two years of treatment. However, for HPV-related throat cancers, recent studies have suggested that distant metastases can occur even five years following treatment. Patients with this disease require long-term close follow-up. Mount Sinai has been a pioneer in the use of ctDNA for follow-up care. This highly accurate test can allow for earlier detection and treatment if the cancer recurs.

Should I get a second opinion?

The answer should always be ‘yes.’ Patients need to be able to fully explore their options and to familiarize themselves with centers that have the most experience with all treatment options for this disease, whether that be TORS or non-surgical therapy.

New York City Is Reopening. Is it Safe to Date Again?

For much of spring, New York City bars, restaurants, and other public gathering spots remained empty of patrons as New Yorkers adhered to the strict social distancing mandate that helped flatten the curve of COVID-19. But, as the city moves through its phased reopening and people expand their social circle, is it safe to have in-person dates again?

Lina Miyakawa, MD, Assistant Professor, Medicine (Pulmonary, Critical Care, and Sleep Medicine) at the Icahn School of Medicine at Mount Sinai, explains how to seek intimacy while protecting yourself and any partners from COVID-19.

New York City is slowly reopening. As we enter a “new normal” with COVID-19 as a persistent threat, is it safe to re-enter the dating world?

I strongly agree with the recommendations from the U.S. Centers of Disease Control and Prevention (CDC) the World Health Organization to wear masks, socially distance, and practice hand hygiene. While I remain optimistic that our world will thrive again, this pandemic is far from over and another surge is a very real possibility.

If you are thinking about dating, you should consider the risks of any interaction and weigh the risk of possibly infecting yourself or a loved one. These are not easy decisions to make. But we can use this time for self-development as well as to build new skills of communication and intimacy.

Also, it is important to remember that COVID-19 recommendations continue to be updated as we learn more about the disease. Everyone should stay up to date with safety recommendations issued by their state and locality.

If you have decided to have in-person dates, when is it appropriate to have non-masked interactions?

There are currently no guidelines to inform us on how to transition from masked to non-masked interactions. However, it is important to note that mask wearing is based on a risk profile—low, medium, and high. For example, low risk would be walking alone through a secluded section of Prospect Park; medium risk would be strolling along Orchard Beach with a friend; and high risk would be boarding a crowded 7 train. The transition from masked to non-masked interactions should also be based on a risk profile.

To assess your partner’s risk profile, you can ask them these questions:

  • How many contacts do you have on a daily basis?
  • Who do you live with?
  • Do you leave the house? If so, where do you go?
  • Do you follow the recommendations to mitigate the risk of exposure, like wearing a mask and practicing social distancing?
  • Do you work in situations with high exposure risk?

Also, don’t forget considering your own risk profile. Do you have an at-risk contact (such as a grandparent or a friend with chronic medical problems) who you see regularly?

Is the virus spread through sex?

Although COVID-19 has been detected in semen and feces, currently we do not think that the virus is spread through the sexual act. But, given that the virus is spread through respiratory droplets—which are much more likely to be shared when in close contact with another person—many sexual acts will be considered high risk. So, as the New York City Department of Health details in its safer sex and COVID-19 fact sheet, minimizing risks by exploring other avenues of meaningful interaction is suggested and recommended.

What should you look for after being intimate with someone new?  

After a close, high-risk encounter like sex, you should be mindful of your personal risk of contracting and falling ill to COVID-19 as well as the risk you may pose to those in your own circle. I recommend monitoring yourself closely for any symptoms of COVID-19 (fever, shortness of breath, cough, fatigue, the loss of taste and smell). Also, consider getting a COVID-19 test five to seven days after the interaction. I would also refrain from interacting with any at-risk persons within a 14 day period after the encounter. If you cannot avoid contact with a high-risk individual, take precautions to lower your risk profile by social distancing, choosing to interact with the individual in outdoor spaces as opposed to indoor spaces, and wearing a mask.

What do you tell patients who are frustrated with quarantine and eager to expand their social circle again?

I recognize that it’s not easy to practice social distancing and I acknowledge that human connection and touch is important.

However, just as it is common courtesy to step aside to create space for someone to walk by, you should wear a mask to protect others—as you may be an asymptomatic carrier. And, prior to opening up your circle, you should carefully consider your risk profile and that of your potential partner.

We are all linked in this global fight against COVID-19 and we have to look out for each other to stay safe. The most dangerous illusion you can have during a pandemic is that it’s only happening to other people, someplace else.

Is PrEP Safe?

“There are certain drug toxicities associated with mostly all medications. PrEP uses antiretroviral medication, and we like to monitor our patients every three months. The toxicities that are usually associated with this medication include kidney damage, liver dysfunction, and it can decrease a person’s bone density.So we like to monitor for osteoporosis, as well. when the patient comes in – we like to have them come in every three months – we do blood work to monitor their kidney function, their liver function. We monitor their cell counts because there can be fluctuations as well. It is a safe medication to take as long as patients comply with the follow up.”

Monaa Zafar, MD, is a board certified primary care doctor at Mount Sinai Doctors, seeing patients Monday-Friday. She has a particular interest in disease prevention, health promotion, and chronic illnesses. Dr. Zafar is fluent in Urdu and Spanish. Mount Sinai Doctors is an organization of clinical relationships and multi-specialty services that expand the Mount Sinai Health System’s footprint beyond the seven main hospital campuses into the greater New York City area.

What is the Difference Between PrEP and PEP?

 

“PrEP is pre-exposure HIV prophylaxis, whereas PEP is post-exposure HIV prophylaxis. We use antiretroviral medication in both strategies. However PEP is a 28-day course, and the patient typically has to present within 72 hours of exposure to HIV. PrEP is continued for as long as a patient is at an increased risk of exposure to HIV and transmission of HIV.”

Monaa Zafar, MD, is a board certified primary care doctor at Mount Sinai Doctors, seeing patients Monday-Friday. She has a particular interest in disease prevention, health promotion, and chronic illnesses. Dr. Zafar is fluent in Urdu and Spanish. Mount Sinai Doctors is an organization of clinical relationships and multi-specialty services that expand the Mount Sinai Health System’s footprint beyond the seven main hospital campuses into the greater New York City area.

How Do You Know If You Have A Sexually Transmitted Infection (STI)?

“Sexually transmitted infections or STIs are quite common in young people and usually associated with not using condoms when having sex. It’s very important that a young person be aware of this and be checked for sexually transmitted infections, in particular if they’re not using condoms. Sexually transmitted infections sometimes have symptoms such as burning, itching, and discharge but can occur without any symptoms at all. That’s why it’s very important that several times a year a young person who is sexually active gets tested. Testing is through the urine and it is very easy and painless. You should see a specialist in adolescent medicine.”

Paula Elbirt, MD, is a board-certified pediatrician, specializing in Adolescent Medicine, at Mount Sinai Doctors Brooklyn Heights. She has several published writings, including: Dr. Paula’s Good Nutrition Guide for Babies, Toddlers, and Preschoolers; Dr. Paula’s House Calls to Your Newborn; and Seventeen Magazine’s Guide to Sex and Your Body. She has a particular interest in adolescent empowerment and risk reduction. Mount Sinai Doctors Brooklyn Heights is a two-floor practice with a walk-in urgent care center and more than 35 specialties. Located at 300 Cadman Plaza West, the practice is situated on the 17th and 18th floors.

What Are Some STD Myths?

“Many young people believe that if there is no ejaculation then there is no risk of STI, sexually transmitted infection, or pregnancy. Neither of those are true. In fact, any time there is contact between the penis and the vagina, there is opportunity for semen or sperm to float into the canal and cause a sexually transmitted infection or to cause pregnancy. Make sure that even though your partner plans on pulling out before ejaculating that you use condoms because you can always have an infection when there’s contact between the two surfaces.”

Paula Elbirt, MD, is a board-certified pediatrician, specializing in Adolescent Medicine, at Mount Sinai Doctors Brooklyn Heights. She has several published writings, including: Dr. Paula’s Good Nutrition Guide for Babies, Toddlers, and Preschoolers; Dr. Paula’s House Calls to Your Newborn; and Seventeen Magazine’s Guide to Sex and Your Body. She has a particular interest in adolescent empowerment and risk reduction. Mount Sinai Doctors Brooklyn Heights is a two-floor practice with a walk-in urgent care center and more than 35 specialties. Located at 300 Cadman Plaza West, the practice is situated on the 17th and 18th floors.

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