Mount Sinai Hosts Landmark Symposium on Urologic Oncology

Updated on Dec 14, 2023 | Community, Featured, Research

James Tisch, left, Co-Chairman of the Boards of Trustees of the Mount Sinai Health System, and Ash Tewari, MBBS, MCh, Chair of the Milton and Carroll Petrie Department of Urology.

The Department of Urology at the Icahn School of Medicine at Mount Sinai recently took center stage in the global medical community by hosting the Fifth International Prostate Cancer Symposium and World Congress of Urologic Oncology.

The event, held Friday, December 8, to Sunday, December 10, is considered a cornerstone in prostate, kidney, and bladder cancer. The event drew more than 500 registrants, including 90 of the world’s most renowned experts from more than 20 countries, and showcased groundbreaking research and clinical practices poised to redefine cancer care and impact patient outcomes worldwide.

A significant highlight was the presentation of the first Golden Robot Surgical Award for Excellence in Surgical Innovations for Cancer Patients to Ash Tewari, MBBS, MCh, Chair of the Milton and Carroll Petrie Department of Urology at Icahn Mount Sinai. This award was presented by Merryl and James Tisch, Co-Chairman of the Boards of Trustees of the Mount Sinai Health System, during a gala at the Pierre Hotel. The award recognizes a significant leap in medical innovation and patient care. Also attending were Brendan Carr, MD, MA, MS, whose appointment as Chief Executive of the Mount Sinai Health System is effective early next year, who opened the gala event, and Margaret Pastuszko, President and Chief Operating Officer.  Click here to watch a video shown at the gala titled “A Decade of Excellence: Dr. Ash Tewari’s 10-Year Voyage at the Department of Urology.”

Participants included 90 of the world’s most renowned experts from more than 20 countries.

Three Mount Sinai leaders opened the symposium: Dr. Tewari, Dennis S. Charney, MD, Anne and Joel Ehrenkranz Dean of Icahn Mount Sinai, and David Reich, MD, President,The Mount Sinai Hospital and Mount Sinai Queens. Their insightful opening remarks set the tone for what was to be an intensive three-day exploration of the latest advancements and challenges in urologic cancer care.

One of the symposium’s highlights was an engaging presentation by best-selling author Deepak Chopra, MD, a pioneer in integrative medicine and a prolific writer titled “Major Breakthroughs in the Science of Healing.” Dr. Chopra’s talk focused on integrating AI with the holistic interplay of mind, body, and spirit in medical science.

The event also highlighted technological innovation in medical communication and education, featuring state-of-the-art holographic presentations by Declan Murphy, MB, BCh, BaO, Consultant Urologist, Peter MacCallum Cancer Centre, Melbourne, Australia, and Alberto Breda, MD, PHD, Chief, Uro-Oncology Unit and Kidney Transplant Surgical Program at Fundació Puigvert in Barcelona.

Additionally, a stimulating debate between Mount Sinai radiation oncologist Richard Stock, MD, and robotic surgery pioneer Mani Menon, MD, Professor and Chief of Strategy and Innovation at the Department of Urology, offered contrasting perspectives on treating intermediate-risk prostate cancer.

Ketan Badani, MD, the Department’s Vice Chair and Director of Robotic Operations, and other renowned speakers enriched the symposium with their expertise on modern surgical techniques in kidney cancer, fostering a collaborative learning culture.

The symposium’s final day, led by Peter Wiklund, MD, PhD, Professor and Director of the Bladder Cancer Program, showcased advanced surgical procedures and a panel discussion with Reza Mehrazin, MD, Associate Professor, and John Sfakianos, MD, Assistant Professor, providing deeper insights into bladder cancer management.

Interactive sessions, including live surgical demonstrations, 3D video presentations, and hands-on experiences in simulation laboratories, underscored the event’s commitment to innovative and experiential learning.

Reflecting on the symposium’s impact, Dr. Tewari noted, “This gathering served as a dynamic platform for exploring the various facets of urology and robotic surgery. The exchange of ideas and insights among our peers underscores our collective capacity to shape the future of urologic oncology significantly.”

 

Watch a slideshow of photos from the event:

Learn more about Urology at Mount Sinai

Miriam Merad, MD, PhD: Overcoming Doubt and Redefining Immunology

Nov 30, 2023 | Featured, Research

Miriam Merad, MD, PhD: Overcoming Doubt and Redefining Immunology

About 17 years ago, when Miriam Merad, MD, PhD, had barely started her lab at the Icahn School of Medicine at Mount Sinai to research macrophage lineages, she was having trouble attracting grants from the National Institutes of Health (NIH).

Macrophages are a group of immune cells found in all organs, constantly surveying for potential threats and ensuring elimination of damaged cells and dead cells. During her fellowship at Stanford University, Dr. Merad discovered that in contrast to the dominant understanding that macrophages are recruited from blood circulation, some macrophages are independently renewed locally in tissues. She hypothesized that these self-renewing macrophages played a key role for the maintenance of tissue integrity.

But knowledge and awareness of the topic were too nascent at the time, and there weren’t sufficient experts on the grant committees who recognized the value of the research, said Dr. Merad, who is now the Mount Sinai Professor in Cancer Immunology, Chair of the Department of Immunology and Immunotherapy, and Director of the Marc and Jennifer Lipschultz Precision Immunology Institute at Icahn Mount Sinai. For years, it was difficult to convince scientists of the importance of this cell lineage and secure funding. “While I was projecting confidence, I was doubting, too, whether I was on the right path,” said Dr. Merad.

Fast forward to October 2023, and that perseverance paid off: Dr. Merad was elected to the National Academy of Medicine (NAM), making her one of the few scientists at Mount Sinai to hold dual membership with the National Academy of Sciences, which she was elected to in 2020. The appointments were for her discovery of this new lineage, and that body of work has ignited research around the world on revealing the key role of macrophages in many key physiological processes, including preserving the vascular tone, promoting neuronal function, and contributing to tissue regeneration and repair via stem cell niches.

“Miriam Merad is one of the most renowned immunologist of her generation and has made seminal discoveries in our understanding of the embryonic origin of tissue-resident macrophages and the crucial contribution of these and related cells to the tumor microenvironment,” said Eric Nestler, MD, PhD, Dean for Academic Affairs of Icahn Mount Sinai and Chief Scientific Officer of the Mount Sinai Health System.

“These advances are now driving highly novel clinical trials for lung and other cancers. Mount Sinai is enormously proud of her accomplishments and the leadership role that she serves on campus,” said Dr. Nestler.

Switching Tracks

Early in her medical career, in France during the late 90s, Dr. Merad trained in allogeneic bone marrow transplants and saw how they essentially cured leukemia for some patients. As she moved onto the subject of solid tumors, she noted that the treatment landscape was bleak—especially for metastatic patients, for whom chemotherapy and radiation therapy had limited effect.

As she was studying tumor stains of her patients, Dr. Merad realized that in some tumor lesions, there were more immune cells than cancer cells, which led her to conclude that solid tumors could also be targeted by immune cells. Having come from the hematological oncology field, where immunotherapy had seen success, she saw the potential of tapping the immune system in tackling solid tumor cancers. And so Dr. Merad pursued a PhD at Stanford University to deepen her understanding of immunology, and began a research career in cancer vaccines.

At the time, researchers knew that dendritic cells—responsible for initiating all antigen-specific immune responses—could mount a response against cancer cells, but not enough was known about dendritic cells to harness them. Nor was there great interest in the related lineage of macrophages.

“I thought if we wanted to be serious in harnessing dendritic cells and macrophages to destroy tumor cells, we had to understand everything about these cells, including where they came from and why they accumulated in cancer tissues,” Dr. Merad said.

Persevering Through a Rocky Start

Dr. Merad’s research brought her to Icahn Mount Sinai, where she established a lab to study the lineages of tissue-resident macrophages. That journey had a rough start.

“I managed to produce some nice papers with my seed funding from Mount Sinai, but I had no money otherwise, and I needed more funding to carry out these big experiments that were needed,” she said.

The next step—obtaining formal proof that macrophages had a lineage independent of circulating immune cells existed—required a gene tracing experiment that traces the origin of the cells in the embryo. “It’s very technical research that requires the building of many new expensive tools and experimental models. I was spending a lot of money and I was not getting any grants,” Dr. Merad said.

In order to keep her lab aloft, Dr. Merad had to lay off two people in her group. “I was extremely saddened,” she said. “These people stuck with me through my research, and I kept saying what a fantastic job they were doing. And somehow I let them down.”

Thankfully, about a month later, the group had a big paper published in a leading scientific journal, and that recognition attracted two NIH grants, turning Dr. Merad’s lab around.

What kept Dr. Merad pushing forward was the belief in her research. “I knew the data was reproducible and would have an impact for sure. But new discoveries are always faced with some skepticism by the scientific community. I realized that I needed more successes to convince the community of the clinical relevance of the new discovery,” she said. Dr. Merad then examined the distribution and contribution of these new macrophages to different disease conditions, which gained traction, and now, nearly 15 years after the initial discovery, textbooks have been rewritten and graduate students are now taught about this lineage.

“But new discoveries are always faced with some skepticism by the scientific community. I realized that I needed more successes to convince the community of the clinical relevance of the new discovery.”

—Dr. Merad

“It had been an anxious three years of starting my journey. Despite all the anxiety and the doubts, I always felt strongly supported at Mount Sinai,” said Dr. Merad. In addition to the intellectual engagement she has received from her peers and lab group, she appreciated the support of Dennis Charney, MD, the Anne and Joel Ehrenkranz Dean of Icahn Mount Sinai, who emboldened her belief in her niche line of research.

“We’re from different fields,” she said of Dr. Charney, a psychiatrist, “and when I engaged him to explain my field and my research, he encouraged me to explore further.” Most deans usually don’t want to rock the boat, but Dr. Charney pushed me to find a way to bring the discovery to the clinic, Dr. Merad added.

That encouragement to keep probing despite uncertainty and doubt was why Dr. Merad stayed at Icahn Mount Sinai, even after her research took off, she said. “I came into science because I wanted to change medicine. Mount Sinai is exactly the environment that enables you to do so, aim big despite the uncertainty, and accomplish your dreams.”

A closer look at Dr. Merad's work

Brian Brown, PhD

Brian Brown, PhD, Professor of Genetics and Genomic Sciences, and Dermatology, and Associate Director of the Marc and Jennifer Lipschultz Precision Immunology Institute, explains why Dr. Merad’s body of work in immunology is so impactful.

“Dr. Merad’s work has transformed our understanding of an entire branch of the immune system, which is made up of cells called macrophages and dendritic cells,” said Dr. Brown.

These cells are found in all tissues of the body and influence virtually every disease. Macrophage and dendritic cells used to be thought of as having no variations, but Dr. Merad led the way in showing otherwise—they differ developmentally, reside in healthy and diseased tissues differently, and have different molecule programs, which also means they have different physiological functions.

Uncovering the diversity in these cells, especially at the molecular level, has had a profound impact in our thinking about what these cells do, including how they help fight infections, control tumor growth, or contribute to inflammation, Dr. Brown said. “She helped rewrite our textbook understanding of these cells and really about the immune system itself.”

Prominent papers from Dr. Merad include a 2010 Science study which revealed that adult microglia—primary immune cells of the central nervous system—derive from primitive macrophages, and the paper was cited nearly 3,000 times, according to the journal. Another 2010 Science paper on the development of monocytes, macrophages, and dendritic cells was cited nearly 2,000 times. Dr. Merad has published more than 250 articles, and her works have been cited over 82,000 times, according to Google Scholar.

Dr. Merad’s work on dendritic cells and macrophages has very broad implications for the treatment of many diseases, said Dr. Brown. In cancer, her work is helping therapies to be developed that can enhance immune responses in patient tumors, and clinical trials are running based on concepts and specific molecular pathways she has identified as being important. Similarly, in inflammatory diseases, Dr. Merad has been pioneering the use of single-cell analysis technologies to study disease, and this work has led to new ways to classify disease lesions and predict what types of drugs a patient might respond to, Dr. Brown noted.

The National Academy of Medicine (NAM) only admits 100 individuals each year, and membership is one of the highest honors for a scientist in health and medicine. NAM has more than 2,400 members, and Dr. Merad’s appointment brings Mount Sinai’s membership in this organization to 26 current and emeritus faculty members. Dr. Merad also holds joint membership in the National Academy of Sciences, which she was elected to in 2020.

Mount Sinai Researchers Share Thoughts on the Promise of mRNA Technology, a Nobel Prize-Winning Science

Updated on Oct 27, 2023 | Cancer, Featured, Research, Vaccines

Miriam Merad, MD, PhD, the Mount Sinai Professor in Cancer Immunology (left), and Nina Bhardwaj, MD, PhD, Ward-Coleman Chair in Cancer Research (right), lead some of the most cutting edge research in mRNA technology at the Icahn School of Medicine at Mount Sinai.

The 2023 Nobel Prize in Medicine was awarded jointly to two researchers, Katalin Karikó, PhD, and Drew Weissman, MD, PhD, for their decades-long work on messenger RNA (mRNA), which ultimately led to the successful development of COVID-19 vaccines that made a huge difference during the pandemic.

The concept of using mRNA to deliver genetic instructions was met with a lot of skepticism in the beginning, says Nina Bhardwaj, MD, PhD, Ward-Coleman Chair in Cancer Research at the Icahn School of Medicine at Mount Sinai. Because these molecules were rapidly degraded by the immune system, they were thought to be too transient to be used to express anything therapeutic, such as antigens or other molecules in immune cells, she added.

“It’s really through the two researchers’ sheer hard work and determination and validation, both in the lab and in the clinic, that this became a technology that can be harnessed for patient benefit,” says Dr. Bhardwaj, who is also Director of Immunotherapy and Medical Director of the Vaccine and Cell Therapy Laboratory.

The validation of mRNA as a delivery mechanism has opened the doors to vaccines in many other diseases, including cancer, says Miriam Merad, MD, PhD, the Mount Sinai Professor in Cancer Immunology, and Director of the Marc and Jennifer Lipschultz Precision Immunology Institute (PrIISM) at Icahn Mount Sinai.

“We’ve been quite interested in the mRNA for some time—not only this type but also another called the micro RNA,” says Dr. Merad. Even prior to COVID-19, Mount Sinai researchers have recognized the potential of various RNA for use in vaccines, such as for cancer, she adds.

Read more from Drs. Bhardwaj and Merad on their thoughts on mRNA technology, and learn how Mount Sinai is leading this field with its research.

Katalin Karikó, PhD (left), and Drew Weissman, MD, PhD, were the joint winners of the 2023 Nobel Prize in Medicine. Dr. Karikó, a Hungarian-American biochemist who worked at the University of Pennsylvania, continues her research as a professor at the University of Szeged in Hungary. Dr. Weissman, an immunologist, advances vaccine work at his laboratory at the Perelman School of Medicine at UPenn.

What’s the history of mRNA technology development been like?

Dr. Bhardwaj: There was a lot of skepticism in the beginning about how exogenously-delivered RNA—which we usually think of as these transient molecules that are rapidly degraded—can be utilized to express antigens and other molecules in immune cells. So the concept that could happen was not well accepted initially.

Dr. Merad: Also, much of the early focus was on cancer, and researchers were not obtaining fantastic results. Cancer vaccines are still yielding anecdotal responses, and it might not have anything to do with the technology.

What do you feel was a turning point for that skepticism?

Dr. Bhardwaj: I think, in especially the last decade, this technology was being used a good deal at the National Institutes of Health’s Vaccine Research Center as a platform for developing vaccines against other infectious agents, not COVID-19 at the time. What had been generated from the platform showed promise, in preclinical models.

When the COVID-19 pandemic came along, there were highly immunogenic modified “cassettes” generated wherein one could just plug in antigens—such as the spike protein of the COVID-19 virus—which could be rapidly formulated into vaccines and tested.

But even prior to that, there were ongoing efforts to use this technology as platforms for cancer vaccines, which are now being tested in the clinic with encouraging preliminary results in randomized studies in melanoma.

Dr. Merad: I think the big two were the lipid nanoparticle (LNP) as a delivery mechanism, and of course, a disease that somehow was the perfect case to try this new therapeutic strategy.

Drs. Karikó and Weissman were able to change up the RNA prior to the injections so that the molecules persisted longer. They were making clear advances in the way the proteins were being made. But, still, the real fixes started when they learned to encapsulate the mRNA in nanoparticles.

In fact, Dr. Karikó went to BioNTech (which partnered with Pfizer to produce the COVID-19 vaccine) and Moderna also licensed mRNA technology, and what happened was that two companies developed a way of delivering mRNA. This extra component—the delivery mechanism—was what made therapeutics possible.

Also, the pandemic is kind of a boost for mRNA technology. Because, first, of the number of patients available, and second, we are in a bit of a risk-taking mode. These vaccines were already developed against pathogens, so they just had to be pivoted to COVID-19.

U

One solution that companies like Pfizer/BioNTech and Moderna used to protect the mRNA instructions in their vaccines from being degraded by the immune system was loading them into tiny fat particles known as lipid nanoparticles (LNPs). These delivery vehicles are also able to find the targeted cells, which mRNA molecules alone cannot achieve. Icahn School of Medicine at Mount Sinai honored the efforts of the BioNTech executives during its 54th Commencement in May 2023, conferring upon them honorary Doctor of Science degrees.

Learn more about LNPs and mRNA technology in a Q&A with BioNTech executives

What research is Mount Sinai doing with mRNA?

Dr. Bhardwaj: One exciting line of research includes work from Yizhou Dong, PhD, Professor of Oncological Sciences at Icahn Mount Sinai, who works with the Icahn Genomics Institute and PrIISM. He is one of our newly recruited faculty members, who has been working in this space for quite a while. He has demonstrated that RNA can be used as a platform to introduce various kinds of immune modulators into cells, including dendritic cells, a key cellular potentiator of the immune system.

Dr. Dong uses RNA-LNPs to introduce various types of immune modulators into immune cells and even cancer cells to enhance antitumor immunity. My team is using RNA-LNPs to encode newly identified antigens, such as neoantigens, which arise from mutations in cancer cells, and then use those within vaccine constructs.

In preclinical models, we have shown that such RNA-lipid constructs, developed in-house in The Tisch Cancer Institute, are immunogenic and can have therapeutic benefit in treating cancers. Our goal is to take that to the next level: develop our own vaccine constructs and deliver them into humans.

Dr. Merad: We’ve been interested in exploiting mRNA to translate into specific proteins. We have been very much interested in using mRNA to change the immunosuppressive environment of tumors, where we use mRNA to go into the tumor and start making it look like an infection to induce an antitumor immune response. There is a lot of effort in using mRNA to transform cancer lesions—which can suppress and evade the immune system—into something very inflamed that can be recognized by the immune system and lead to tumor clearance.

One of my colleagues, Brian Brown, PhD, Director of the Icahn Genomics Institute, and Professor of Genetics and Genomic Sciences at Icahn Mount Sinai, is quite interested in using mRNA in different types of disease settings. My lab is mostly looking at inflaming regions in cancer, or reducing inflammation in inflammatory diseases—in this case we use mRNA as cargo to deliver proteins that will dampen inflammation and enable inflammatory lesions to heal.

What do you see as the future of mRNA technology?

Dr. Bhardwaj: I think the breadth is enormous. We can add many different types of immune-enhancing modulators into these particles—not just antigens—including homing receptors and cytokines. RNA platforms have been given intramuscularly and intravenously, and it’s possible you may be able to deliver it intranasally and into the skin, as well as directly into tumors.

The scope of what we can do, what we can encode and add, and the potential combinations with other immunomodulatory agents is vast. I think the field is moving really fast, especially with new companies coming into the field and startups accelerating rapidly.

Dr. Merad: Right now, the big conundrum that we have is: how can we raise an immune response against cancer that is beneficial, without inducing a harmful response against other tissue? I think the answer is delivery.

With mRNA, it provides all the instruction needed for therapeutic effect, but what we are still working on is enhancing that cell-specific delivery system. If we were allowed to bring that instruction to the right compartment, then we can afford to do so much more.

Why a PhD in Biomedical Sciences? Student Ashley Richardson, MSBS, Shares How Mount Sinai Inspired Her to Study Immunology and Microbiology

Updated on Oct 13, 2023 | Research, School

Among the first-year matriculating PhD students who participated in the 2023 Lab Coat Ceremony at the Graduate School of Biomedical Sciences at the Icahn School of Medicine at Mount Sinai was Ashley Richardson, MSBS. In the following Q & A, Ms. Richardson, who is a graduate of the Master of Science in Biomedical Science program, discusses her experiences and aspirations, and why she chose to continue her education at Mount Sinai.

What brought you to Icahn Mount Sinai as a master’s student?

I thought Mount Sinai’s program was really unique because you had the opportunity to do a lot of research and also get clinical experience. At that time, I was deciding between two paths. I knew that I really loved research but I also considered going to medical school. I love that this program allowed me to explore both options. When I was here, I found it to be an amazing program. I had great mentors and the community was great, which inspired me to stay longer.

What were some of your achievements as a master’s student?

I was able to participate in EHOP (East Harlem Outreach Partnership), a student-run clinic at Mount Sinai and, as the Women’s Health Referrals Manager, I got very involved with the organization and the local community. I also worked in a research lab under Dr. Dusan Bogunovic and wrote my thesis paper on genetic susceptibility to Zika Virus infection.

What attracted you to this area of study?

I was attracted to immunology and microbiology because I had a really fabulous professor at the University of Villanova when I was completing my undergraduate degree. He taught us how to analyze research papers, how to truly understand the research that was happening, and how to critique them. At Mount Sinai, I’ve had great mentors who have further increased my interest in these areas.

Why a PhD in Biomedical Sciences?

I’m interested in knowing more about why some individuals respond differently to viral infections. Some people get seriously ill, while others only experience a minor infection. I’m curious about understanding the genetics that can lead to these differences. I hope to further my confidence and ability to lead research projects. I want to keep going forth to understand genetics. My previous skills are mostly in immunology, so I’m aiming to combine this with new knowledge about genetics.

Lab Coat Ceremony for PhD and MD/PhD Students Marks the Start of New Journeys in Research and Training

Updated on Oct 13, 2023 | Featured, Research, School

Amid cheers and applause, first-year PhD students and third-year MD/PhD students received crisp white lab coats to mark the start of their journeys into academic research and training during a recent ceremony held by the Graduate School of Biomedical Sciences at the Icahn School of Medicine at Mount Sinai. The lab coats symbolize the professionalism and authority that trainees will develop and nurture during their time at Mount Sinai.

“Our PhD programs in biomedical sciences, neuroscience, and clinical research provide rigorous collaborative training that prepares our students to spearhead the next generation of scientific and medical breakthroughs,” said Marta Filizola, PhD, Dean of the Graduate School of Biomedical Sciences and the Sharon & Frederick A. Klingenstein-Nathan G. Kase, MD Professor as she welcomed the students, faculty, and guests.

Marta Filizola, PhD

Today’s biomedical and clinical research efforts, she said, must help “solve complex problems and find solutions grounded in data and their rigorous statistical analysis. We are branching out into new realms of research that leverage artificial intelligence and other emerging technologies in medicine to improve patient health and quality of life. Our students are a crucial part of this growth.” Dr. Filizola is also Professor of Pharmacological Sciences, Neuroscience, and Artificial Intelligence and Human Health.

Eric J. Nestler, MD, PhD, Dean for Academic Affairs at Icahn Mount Sinai, and Chief Scientific Officer for the Mount Sinai Health System told the students: “We want you to aim high…Don’t settle on a project because it’s easy and doable. Instead, take a chance by studying something that in its own small way will change the world.”

Why a PhD in Biomedical Sciences? Click here to read how student Mount Sinai lnspired student Ashley Richardson to study immunology and microbiology.

Dr. Nestler said, “I’ve given a lot of thought over the years to what constitutes the essential ingredients for such an undertaking. First, is novelty. Dr. Albert Einstein once said, ‘If you do what you always did, you will get what you always got.’” He also mentioned relevance of the work, technical innovation, creativity, collaboration, perseverance—and “having an available and generous principal investigator and other members of your lab who can also help with brainstorming, troubleshooting, and collaborative experiments [and who] should also support your goals of thinking big, having big expectations for yourself, and publishing your work as high-impact papers in respected, peer-reviewed journals.” Dr. Nestler is also Director of The Friedman Brain Institute and Nash Family Professor of Neuroscience at Icahn Mount Sinai.

Eric J. Nestler, MD, PhD

Genomic scientist Brynn Levy, M.Sc.(Med), PhD, FACMG, who received his PhD degree in clinical cytogenetics from Mount Sinai in 1999 and is world-renowned in the clinical utility of genomic technologies in reproductive medicine, gave an insightful speech about his own educational journey and experiences.

“The first piece of advice I have for you is: be an active participant in your profession, and get involved. As you begin to entrench yourself in your profession, try to be more than just a sideline observer,” he told the students. Also, “It’s important to enjoy what you do” and to “treat every day as a learning experience. Identify great mentors and embrace them, as great mentors teach you more than just medicine and science.”

Dr. Levy is Professor of Pathology and Cell Biology at the Columbia University Irving Medical Center (CUIMC), Medical Director of the Clinical Cytogenetics Laboratory at New York Presbyterian Hospital, and Co-Director of the Laboratory of Personalized Genomic Medicine at CUIMC.

Dr. Levy said that he was fortunate to have “two amazing mentors”—the late Kurt Hirshhorn, MD, at Mount Sinai, and the late Dorothy Warburton, PhD, at Columbia, each a trailblazing researcher in the cytogenetics field.

Dr. Hirshhorn was a legendary pediatrician, medical geneticist, and cytogeneticist known for groundbreaking research during his 50-year career at Mount Sinai, which included establishing one of the first laboratories in the nation for clinical chromosome studies. Among his many honors, he was a member of the National Academy of Medicine. “Kurt led by example,” said Dr. Levy. “Over and above his phenomenal accomplishments and knowledge, he taught me how to have confidence in myself. He never micromanaged me, and instead, he gave me autonomy…He taught me the meaning of paying it forward, possessing the insight of the importance of investing in the next generation.”

Brynn Levy, M.Sc.(Med), PhD, FACMG

Dr. Levy concluded: “As you all embark on the exciting new pathway that you’ve chosen for yourselves, I hope you invest in yourselves. Get involved in your field and engage with your community and colleagues. Be curious and treat every day as a lesson in medicine, science, as well as life. Know your limitations, and see those around you as a resource to continuously improve who you are and what you do. In doing so, I trust that every day will be fulfilling, and you will no doubt make an indelible impact on many patients’ lives and on society as a whole.”

With great fanfare, each student was presented with a lab coat, an effort sponsored annually by the Mount Sinai Alumni Association. Standing together and wearing their lab coats, they recited the PhD Oath in unison. “With my Doctor of Philosophy, I willingly pledge to uphold the highest levels of integrity, professionalism, scholarship, and honor,” they said, as they read a set of guiding principles that would start them on their journeys to rewarding and enjoyable careers.

A slideshow of snapshots from the Lab Coat Ceremony

Mount Sinai Researcher Launches Three Studies of Alzheimer’s Disease in Asian Americans

Updated on Oct 5, 2023 | Diversity and Inclusion, Featured, Psychiatry, Research

Clara Li, PhD, a clinical neuropsychologist and Associate Professor, Psychiatry, at the Icahn School of Medicine at Mount Sinai, has received new grants that will total more than $12 million from the National Institute on Aging (NIA), part of the National Institutes of Health (NIH). The funding will support three new projects that seek to improve the diagnosis and treatment of Alzheimer’s disease and Alzheimer’s disease-related dementias (AD/ADRD) in Asian Americans.

Asian Americans are historically under-represented in clinical research on AD/ADRD. As a result, many older adults with Asian ancestry do not receive adequate diagnosis and treatment for mild cognitive impairment (MCI) or AD/ADRD.

Clara Li, PhD

“Chinese is the third-most-spoken language in the United States after English and Spanish, yet we don’t have many of these tools available,” Dr. Li explains. She’s hoping to change that, with three new studies launched in 2023.

Adapting Assessments for Alzheimer’s: Chinese Translation and Cultural Adaptation

In one of the studies, a five-year effort, Dr. Li will develop assessment tools that are linguistically and culturally adapted for older adults who speak Cantonese or Mandarin, with the hope to extend it to other Asian languages in the future.

Researchers rely on assessment tools from the National Alzheimer’s Coordinating Center Uniform Data Set (NACC UDS) to identify research participants with cognitive impairment or AD/ADRD. But those tests were developed for English speakers and Western cultures.

“I’ve seen many Asian American patients who try to take the English tests because a Chinese version isn’t available, and the language is a barrier,” Dr. Li says. “Sometimes a test would suggest cognitive impairment, but when I would translate the test myself into Chinese, the patient would score in the normal range.”

Language isn’t the only barrier. Cultural differences also make the test confusing for many Asian American patients. When asked to identify an image of a witch on the standard test, for instance, some of Dr. Li’s patients said “janitor” or “cleaner”—a common error because witches aren’t typically depicted with brooms in Chinese culture.

The lack of adequate tests hampers diagnosis and treatment, and also affects research seeking to better understand AD/ADRD in Asian Americans.

“Because we can’t enroll patients unless they can take the tests in English, many are excluded from studies. As a result, Asian Americans make up less than 2 percent of the participants in U.S. clinical trials,” Dr. Li explains. “If we want to increase diversity in research, we need to adapt these materials for Chinese speakers and eventually other Asian languages.”

A Research Infrastructure for Alzheimer’s Disease in Asian Americans

In the second study, Dr. Li will develop a research infrastructure and tools for studying AD/ADRD in older Asian Americans. She and her colleagues will develop questionnaires to fully characterize Asian American participants, including social determinants of health and any environmental or lifestyle factors that could increase or decrease their risk of developing AD/ADRD.

This five-year study will also investigate blood samples from Asian American participants to determine whether there may be novel biomarkers in this population, and whether known biomarkers are relevant to people from Asian backgrounds.

“Amyloid and tau are well known as biomarkers associated with Alzheimer’s disease, but those biomarkers were developed primarily from Caucasian samples. Therefore, the generalization of these findings in Asian Americans is not always clear, including criteria for amyloid and tau burden to establish AD/ADRD risk,” she says. “There may be different thresholds for those biomarkers in different populations.”

Support for Mild Cognitive Impairment

Dr. Li’s third newly funded project is a two-year pilot clinical trial. She and her colleagues will adapt the Memory Support System (MSS) for use in Chinese Americans who speak Cantonese or Mandarin. The MSS is a memory calendar training program to help older adults with MCI organize and remember their daily activities. The system is a component of the Healthy Action to Benefit Independence & ThinkingÒ (HABIT) Program, an evidence-based intervention that provides lifestyle and behavioral treatments for older adults with MCI.

“I see patients with MCI who want to do something to prevent the development of dementia, but if they can’t speak fluent English, they aren’t able to participate in clinical trials,” Dr. Li says. “We hope that by adapting this program, we can offer Chinese American older adults with MCI an opportunity to participate in a trial that seeks to improve memory and function, as well as their mood and quality of life.”

Alzheimer’s Disease Research at Mount Sinai

In addition to the three new studies Dr. Li has launched this year, she is leading two clinical trials at the Alzheimer’s Disease Research Center at Icahn Mount Sinai and is the site Principal Investigator for the Asian Cohort for Alzheimer’s Disease (ACAD) study, a multisite project to analyze genetic data to identify risk variants for Alzheimer’s disease in Asian Americans and Asian Canadians.

Through these projects, she hopes to improve research participation, diagnosis, and treatment related to patients of Asian ancestry—an effort that is long overdue, she says.

“There’s a lot of work that needs to be done. In addition to research inequities, there aren’t enough bilingual physicians outside the community, which often makes it difficult for Asian American older adults to receive integrated specialty care, leading to delayed diagnosis and treatment for AD/ADRD,” she adds.

Mount Sinai serves a diverse patient population and is committed to improving care by addressing bias and racism. Icahn Mount Sinai and Mount Sinai Health System created the Center for Asian Equity and Professional Development to address the equity and professional development challenges faced by Asian Americans and Pacific Islanders.

Learn more about the Alzheimer’s Disease Research Center

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