Mount Sinai Helps Liberia Build Its Sole Pathology Lab

Pathology technicians at work in the new laboratory at John F. Kennedy Medical Center in Monrovia, Liberia.

The only pathology laboratory in Liberia recently opened, thanks to a collaboration led by Ann Marie Beddoe, MD, MPH, Director of Global Women’s Health and Associate Professor of Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai. The laboratory, which became operational in October 2019, is a crucial step in rebuilding the health infrastructure in Liberia after years of civil war. “The impetus for founding this laboratory was our mission to improve women’s health,” Dr. Beddoe says. “But this is not just for women or for cancer. This is something that will benefit the entire country.”

In an event attended by President George Weah of Liberia, the 4,000-square-foot laboratory at the John F. Kennedy Medical Center in Monrovia, Liberia, was dedicated in July 2019, along with an imaging center donated by the National Institutes of Health and an infectious disease center donated by the United States Agency for International Development. The new facilities are part of an overarching mission to provide evidence-based care in Liberia, which was wracked by civil wars for more than a decade. Around 2006, Ellen Johnson Sirleaf, then president of Liberia, noted that only 50 physicians were left in the nation of more than 4 million people, and she sent out a call for volunteers to help restore health care. In 2008, Dr. Beddoe was part of a group from Mount Sinai who answered that call, led by Jeffrey S. Freed, MD, Clinical Professor of Surgery, Icahn School of Medicine at Mount Sinai; and Eileen Solomon, Senior Director, Special Events, Mount Sinai Health System. “Our early teams recognized the need for gynecologic oncology services, and Dr. Beddoe had the courage and fortitude to make it happen,” says Dr. Freed, who has made many trips to Liberia to care for patients there.

From the beginning, Dr. Beddoe was struck by the prevalence of cervical cancer in Liberia. “Women would walk to the clinic, or come in strapped to motorbikes, and when we examined them, we found they were dying of cervical cancer,” she says. “I couldn’t walk away from this.” Low-income nations bear most of the burden of cervical cancer because industrialized nations benefit from widespread prevention, screening, and early treatment. For example, among more than 500,000 new cases of cervical cancer each year, only 14,000 are in the United States, Dr. Beddoe says. In addition, cancer carries a stigma in Liberia. “We couldn’t really treat these patients,” she says. “Nobody even acknowledged that they had cancer.”

Over the years, she has returned to Liberia every few months to work with physicians there to improve the diagnosis and treatment of cancer. The first step in securing any health care funding from the Liberian government is building a registry to document the nation’s cancer burden, Dr. Beddoe says. The creation of the pathology laboratory, where diseases can be diagnosed through the analysis of body fluids and tissues, is integral to this effort.

Ann Marie Beddoe, MD, MPH, at the dedication of the laboratory with Jerry Brown, MD, Chief Executive Officer of the John F. Kennedy Medical Center.

The $250,000 facility was built in a suite of storage rooms at JFK Medical Center and funded partly by The Women Global Cancer Initiative, a nonprofit led by Dr. Beddoe. Sakura Finetek USA, a pathology supply company, donated equipment, including a tissue processor and slide stainer, and Mount Sinai donated computers and printers, and a year’s worth of “consumable” supplies, such as reagents, alcohol, blades, and gloves.

Staffing the laboratory presented a challenge. Licensed clinical laboratory technicians—known as histotechnicians—are crucial to a pathology laboratory, and there were none in Liberia. So in 2019, four Liberians were trained by the American Society of Clinical Pathology, a crucial partner in the project. JFK Medical Center hired two physicians specializing in pathology, and other physicians at the hospital are being trained in handling and labeling specimens and in the discipline of evidence-based medicine.

“I am 99 percent sure that when I see a cervical cancer, it’s a cervical cancer, but that is not the way to introduce cancer care to a country that is trying to do things right,” Dr. Beddoe says. “Having pathology, and good diagnoses, will start generating more research, which is what you need to provide good medicine.”

Mount Sinai’s Division of Global Women’s Health focuses on the long term in its overall mission to improve research and clinical care. “We try to do a lot of capacity building—training people, and focusing on ongoing, sustainable projects,” Dr. Beddoe says. Her years of dedication were acknowledged at the ceremony in July, when the pathology laboratory was dedicated in her name.

Football Star Brings Inspiration to Young Patients

2019 Heisman Trophy winner Joe Burrow met with pediatric patients, including Ryan Diaz.

Patients and families at the Child Life Zone at Mount Sinai Kravis Children’s Hospital received a special visit on Sunday, December 15, from Joe Burrow, just a day after he was named the 2019 Heisman Trophy winner. The Louisiana State University quarterback hosted a special trivia-themed episode on KidZone TV, answered questions, opened up about his personal life and adversity, and provided inspiration to patients and their families in an appearance made possible through the Companions in Courage Foundation.

Mr. Burrow also signed football keepsakes for the patients, much to the delight of one 13-year-old patient, Ryan Diaz, an aspiring football player himself. Ryan already has helped his Harlem Jets youth football team win two championships—no easy feat for this offensive guard and center who happens to have severe asthma.

“He has had asthma since he was a baby, and he has been in and out of the hospital,” recalled his mother, Christina Ortiz. “He would miss up to 18 days a year of school.” Added Ryan: “It was really hard. I would miss so many things because I couldn’t control my asthma. I struggled so much from something I didn’t cause.”

“We have many, many patients like Ryan with severe asthma,” said Alfin G. Vicencio, MD, Vice Chair for Clinical Affairs and Strategy, and Division Chief for Pediatric Pulmonology at Kravis Children’s Hospital, who started treating Ryan in September 2018. “He has multiple triggers, and it’s hard to isolate one thing, so what is your recourse, stay inside a bubble?”

Ryan Diaz with Alfin G. Vicencio, MD

Dr. Vicencio is primarily treating Ryan with an injection of omalizumab, a monoclonal antibody, every two weeks. “This medication targets very specific molecules that are important in the asthma-inflammation cascade,” said Dr. Vicencio. The treatment acts to decrease the number of sudden episodes of wheezing, shortness of breath, and trouble breathing in individuals whose symptoms are not controlled with inhaled steroids.

“Mount Sinai has a very active program for the diagnosis and treatment of children with severe asthma,” said Dr. Vicencio. “This includes some important research initiatives that are starting to identify new subtypes of asthma, some of which may be driven by unsuspected infections.”

Other components of the research program, he added, are starting to identify new genes in the airway that may contribute to severity. This is part of a collaborative project with Supinda Bunyavanich, MD, MPH, MPhil, Professor of Pediatrics, and Genetics and Genomic Sciences, aimed at finding new therapeutic targets for patients with severe disease.

Following this protocol has allowed Ryan to keep active—except for when he was sidelined for two weeks in February with the flu and pneumonia. He is now able to resume his strenuous four-hour weekend football workouts and continue his participation in a dance and theater program.

Throughout it all, he has excelled in middle school, which has earned him an academic scholarship to Archbishop Stepinac High School in White Plains, New York, a football powerhouse.

“I just love football,” said Ryan, whose father, Juan Diaz, a registrar in Mount Sinai’s Institute for Advanced Medicine, played football for George Washington High School in New York City and has been a coach for the Harlem Jets since 2013. “It is a bond,” said Ryan.

Mr. Burrow is now certainly part of this bond, too. “It was really inspiring to speak with someone of that caliber,” said Ryan. “We talked about football, staying in school, and doing your best. One thing that made me proud—he signed my football jersey, and I gave him a signed Ryan Diaz #74 Harlem Jets hat, which he wore for the entire event.”

As for the football that Mr. Burrow signed, Ryan said he no longer has it. “We decided to give it to Dr. Vicencio because he has done so much for me. He let me lead a normal life. He really likes football, and I felt he really deserved that,” said Ryan. “I felt very, very touched,” said Dr. Vicencio. “I told Ryan that when he is in the National Football League, I will ask for one of these signed by him.”

Examining the Effects of Immunotherapy on Cancer

From left: Thomas Marron, MD, PhD; Adeeb Rahman, PhD, Associate Professor, Genetics and Genomic Sciences; and Miriam Merad, MD, PhD

Using a collection of sophisticated single-cell technologies, scientists at the Mount Sinai Health System have launched an early-stage clinical trial that examines the effects of immunotherapy on hepatocellular carcinoma, non-small-cell lung cancer, and head and neck squamous cell carcinoma.

Four to six weeks before a tumor is resected, the researchers administer a neoadjuvant immunotherapy, cemiplimab, and study its effects. As soon as the tumor is removed, they continue to analyze the fresh tissue for a month or more to observe mechanisms of resistance and response. The Phase 1 trial is sponsored by Regeneron Pharmaceuticals, Inc.

“With the technologies available to us at The Tisch Cancer Institute and Mount Sinai’s Human Immune Monitoring Center, we are able to investigate at an unprecedented depth how these immune therapies are changing the microenvironment within the tumor,” says Thomas Marron, MD, PhD, Assistant Professor of Medicine (Hematology and Medical Oncology), Icahn School of Medicine at Mount Sinai, and Principal Investigator of the study. “This trial enables us to analyze fresh tissue immediately after resection—instead of the preserved tissue typically obtained in trials—to observe the dynamic changes that occurred.”

The study is enrolling multiple small cohorts of 21 patients. One goal is to determine which cancer patients will benefit from cemiplimab, and, more specifically, how cemiplimab can be more effective by combining it with chemotherapy and/or other novel immunotherapies. Cemiplimab was previously studied at Mount Sinai in liver and lung cancer patients and has been approved by the U.S. Food and Drug Administration for patients with metastatic cutaneous squamous cell carcinoma. The compound works by inhibiting the interaction between PD-L1, a protein on the surface of tumor cells, and PD-1, the protein on the surface of T cells, and restoring the immune system’s ability to recognize and kill cancer cells.

Another goal of the study is to identify biomarkers in human tissue and blood that will be able to predict who will respond to immunotherapy, since so many patients do not respond to anti-PD-1 therapy. “We really need to find the ideal patients to treat so we don’t unnecessarily expose those who won’t respond to the toxicity of immune therapies,” says Dr. Marron, who is also Assistant Director of Early Phase and Immunotherapy Clinical Trials at Mount Sinai. “There’s also a financial issue at stake for patients and society in general in using expensive drugs that are not improving outcomes.”

Dr. Marron and his team are using several powerful new technologies to help them with their work. These include immune mapping and monitoring technologies such as mass cytometry (CyTOF), a flow-cytometry-like technology that allows them to see up to 50 proteins on each cell so they can identify the cell type and classify the maturation and activation status of the cell, along with some of the regulatory “on/off” checkpoints.

CITE-Seq (Cellular Indexing of Transcriptomes and Epitopes by Sequencing) is another platform that provides an even higher resolution view of each individual cell within the tumor. This technology combines the capabilities of CyTOF and single-cell RNA sequencing to characterize both the RNA and protein in each cell.

A third technology is known as Multiple Ion Beam Imaging (MIBI), a unique form of immunohistochemistry that allows scientists, for the first time, to unravel the spatial architecture of tumors in order to better understand the mechanisms through which the immune system is infiltrating the tumor and is being hijacked by the tumor.

“For 10 years, we’ve been building the Human Immune Monitoring Center into one of the leading platforms in the world for investigating the role of the immune system in human disease, and using that knowledge to design novel, immune-based therapies,” says Miriam Merad, MD, PhD, Director of the Center, and Professor of Oncological Sciences, and Medicine, Icahn School of Medicine at Mount Sinai.

Drawing on a highly specialized team of clinicians, immunologists, mathematicians, physicists, and surgeons, the Human Immune Monitoring Center is currently involved in more than 45 federal- and foundation-funded research programs in fields such as cancer, autoimmune disease, inflammatory bowel disease, allergies, and neurodegenerative disease.

Advancing the Study of Brain and Memory

Denise Cai, PhD

Denise Cai, PhD, Assistant Professor of Neuroscience, Icahn School of Medicine at Mount Sinai, is the recipient of a 2019 National Institutes of Health New Innovator Award to continue her novel research into the brain and memory.

The Award was established to accelerate the pace of biomedical, behavioral, and social science discoveries by supporting exceptionally creative early-career scientists with high-impact ideas. It provides Dr. Cai with $2.5 million in funding over five years.

Dr. Cai’s research is driven by two perplexing questions: How, precisely, does the brain optimize its capacity and efficiency to store memories? And, how do these processes change over time?  She and her research team will use a number of innovative approaches to further explore these concepts.

The effort includes the recording of neural activity in the brains of both younger and older study mice as they learn new spatial locations through a novel, wire-free miniature microscope known as the Miniscope system, which was co-developed with colleagues at the University of California, Los Angeles, and the Icahn School of Medicine. Using this new technology, the mice will wear tiny, head-mounted, wire-free microscopes as they enter a variety of different environments, enabling researchers to record and analyze thousands of neurons over the course of time.

“We will use a variety of techniques to observe and manipulate these populations of neurons to determine how the neural activity in the brain controls the animals’ behavior,” explains Dr. Cai. “Ultimately, we aim to learn how the brain optimizes its capacity to store information across a lifetime. I am tremendously grateful to have received the New Innovator Award, which will enable our lab to explore some fundamental, yet very complex, biological questions in the field of memory and cognition.”

Amid Transformation, Mount Sinai St. Luke’s Is Renamed Mount Sinai Morningside

From left: David A. Feinberg, Senior Vice President, Chief Marketing and Communications Officer, Mount Sinai Health System; and Mount Sinai Morningside leaders Berthe Erisnor, MBA, Vice President, Ambulatory Services; Arthur A. Gianelli, MBA, MPH, President; Brian Radbill, MD, Chief Medical Officer; Audrey Madison, PhD; Director, Marketing and Communications; and Lucy Xenophon, MD, MPH, Chief Transformation Officer.

Mount Sinai St. Luke’s will now operate under the name Mount Sinai Morningside, reaffirming its commitment as the primary provider of health care in West Harlem, including Morningside Heights, and its integral role in the Mount Sinai Health System. The change was approved by the Mount Sinai Boards of Trustees and the appropriate regulatory agencies. It becomes effective immediately.

“This new name not only reaffirms our 124-year legacy of serving the local community, but also our commitment to delivering technologically advanced Mount Sinai-level care to our patients, who are increasingly coming to us from all five boroughs, Westchester, New Jersey, and even internationally,” said Arthur A. Gianelli, MBA, MPH, President of Mount Sinai Morningside and Chief Transformation Officer, Mount Sinai Health System. “We have undergone a transformation that positions Mount Sinai Morningside as an integral part of the Mount Sinai Health System. Our patients now have convenient access to a vast network of world-renowned physicians and cutting-edge medical care.” Mr. Gianelli announced the change on Thursday, February 6, in two Town Hall meetings for hospital staff—one at 2 pm for the day shift, and one at 11 pm for the night shift.

Kenneth L. Davis, MD, President and Chief Executive Officer, Mount Sinai Health System, said, “Mount Sinai Morningside has grown into a top-tier health care facility that serves as this region’s gateway to the Mount Sinai Health System, expanding access for Upper Manhattan, New Jersey, Yonkers, Westchester, and surrounding areas. The hospital’s rebranding and transformation efforts reaffirm our commitment to setting standards for excellence and innovation in health care.”

The renaming was announced to Mount Sinai Morningside faculty and staff at Town Hall meetings.

The transformation of Mount Sinai Morningside is the result of hundreds of millions of dollars in investments in clinical services, facilities, equipment, and information technology. Centers of excellence have been established in cardiology and cardiac surgery; diabetes/endocrinology and bariatric surgery; geriatrics; and trauma services. The hospital has also introduced a state-of-the-art electronic medical record (EMR) system and acquired advanced surgical robotic technology.

Mount Sinai Morningside has earned a number of important designations. The Centers for Medicare and Medicaid Services recently awarded the hospital a 4-star out of 5-star rating for safety, quality, and patient experience. Two of the hospital’s clinical services—diabetes/endocrinology and nephrology—are ranked among the best in the country by U.S. News & World Report. It has secured accreditation from the American College of Emergency Physicians as a Geriatric Emergency Department and by the Institute for Healthcare Improvement as an Age Friendly Health System. Mount Sinai Morningside operates one of just two Trauma Centers certified by the American College of Surgeons located north of 60th Street in Manhattan. And the Healthcare Information and Management Systems Society granted Mount Sinai Morningside the highest rating (Stage 7) for the adoption and utilization of its EMR, a designation received by only 7 percent of hospitals across the country.

The hospital was founded by the Reverend William Augustus Muhlenberg in 1846 and opened its doors in 1858.

The hospital in 2018 opened the James P. Jones Daily Management and Incident Command Center, an innovative facility that uses the EMR system and data science to provide descriptive and predictive information to decision-makers so that they can respond quickly and effectively to emergencies. In addition, Mount Sinai Morningside has opened a new Ambulatory Care Center at 114th Street and Amsterdam Avenue, which includes outpatient exam space for a variety of clinical specialties, an imaging center, an infusion suite, and numerous diagnostic and procedural centers. Primary care services are now available in a new space at 91st Street and Columbus Avenue, as well as at 147th Street and Frederick Douglass Boulevard in the Sugar Hill community.

Since the mid-19th century, the hospital has been a vital part of health care in New York City. It was founded as St. Luke’s Hospital in 1846 by the Reverend William Augustus Muhlenberg, and in 1858 opened its doors to patients at Fifth Avenue and 54th Street. It relocated to 113th and Amsterdam in 1896, and merged with the Woman’s Hospital in 1953, with Roosevelt Hospital in 1979, and with Mount Sinai in 2013.

In every iteration, the hospital has been dedicated to the care of all patients—especially women and underserved populations—and to innovation in health care. Among many milestones, in 1897, St. Luke’s pioneered the diagnostic and therapeutic use of X-rays; in 1935, it performed one of the earliest removals of a cancerous lung; in 1975, it opened the first hospital-based hospice program; and in the 2000s, it has set national benchmarks in cardiac surgery and HIV clinical care.

At the afternoon Town Hall meeting, a capacity crowd greeted the name change with surprise and applause. During the question-and-answer session, there was a candid and spirited discussion about how best to recognize the historic legacy of the St. Luke’s name. Lisa Renaud, Practice Manager, said to Mr. Gianelli, “This is an emotional roller coaster, but I just want to thank you for taking a few minutes to share with us the importance of change.” Keith Guerra, Associate Director of Security, was enthusiastic: “I’m psyched about this. This is reality; this is where we are. And the people who are here are the people who are going to make this work. So let’s go, Morningside!”

Circa 1908, St. Luke’s Hospital, right, was already a mainstay in Upper Manhattan. At left is the Cathedral of St. John the Divine, still under construction.

The hospital pioneered the diagnostic and therapeutic use of X-rays in the 1890s.

The men’s hospital ward in the 1940s.

Renowned Microbiologists Explain the Coronavirus

The novel coronavirus is transmitted through the air and replicates in the respiratory system and in blood.

The novel coronavirus that began in Wuhan, China, has been labeled a Public Health Emergency by the U.S. government. As confirmed cases of the coronavirus now known as COVID-19 continue to increase in this country and around the world, and additional information unfolds, two renowned microbiologists at the Icahn School of Medicine at Mount Sinai, Peter Palese, PhD, and Adolfo García-Sastre, PhD, recently provided insights into the disease. Dr. Palese is the Horace W. Goldsmith Professor and Chair of the Department of Microbiology, and Professor of Medicine (Infectious Diseases); and Dr. García-Sastre is the Irene and Dr. Arthur M. Fishberg Professor of Medicine (Microbiology, and Infectious Diseases), and Director of the Global Health and Emerging Pathogens Institute.

What is COVID-19?
Dr. Palese: It belongs to a group of viruses known as coronaviruses, to which the SARS (severe acute respiratory syndrome) virus and MERS virus (Middle East respiratory syndrome) belong. It is transmitted through the air and replicates in the respiratory system and in blood.
Dr. García-Sastre: The COVID-19 and the SARS-CoV are closely related and they originated from bats. In the case of the COVID-19, we are not yet sure of its precise origin—whether the virus went directly from bats to humans or whether it went from bats to a host animal and then to humans, which is what happened with SARS. But we believe it originated from bats.

The SARs outbreak in 2003 is different from the novel coronavirus in that it was traced to civet cats and raccoon dogs, which were eaten as a delicacy in some parts of China. The animals were originally infected by bats—either through bites or by breathing in bat urine and feces. MERS, a respiratory illness relatively new to humans and traced to the Arabian Peninsula, is believed to have been spread by camels that were also infected by bats.

How did this novel coronavirus start?
Dr. Palese: Samples of the virus were found in a large fish market in Wuhan where other live animals are kept in cages and sold as food.

Dr. García-Sastre: People went to the market to buy food and were exposed to the virus, which infects through the respiratory tract. Like the flu, it is spread by aerosols.

What are the most important factors to consider as the disease unfolds?   
Dr. Palese: The reproduction number, or “R” number, appears to be around 2.5. That means every person who is infected will pass the disease on to 2.5 other people. The influenza virus is a little lower. Measles has a much higher R number of about 18. These are averages. But we have to be vigilant. There are reports that the disease can be transmitted for about 24 hours before symptoms develop. If that is confirmed, it would make it more difficult to contain. The disease caused by the novel coronavirus is accompanied by flu-like symptoms, including very high fever. Fatalities stem from pneumonia and comorbidities, such as old age, asthma, or chronic obstructive pulmonary disease.
Dr. García-Sastre: Don’t panic. The virus does not seem to be associated with very high mortality. It is progressing more quickly than the SARs virus did, but it also appears to be less deadly. The rate of transmission appears to be similar to that of the seasonal flu. That is an estimate because we don’t know for sure whether all of the people who have the disease have been diagnosed. Some may have very mild cases. Another consideration is at what moment does an infected person begin to transmit the virus? With flu, people can transmit the disease before there are symptoms. With SARS, most transmissions happen after there are symptoms.

Are vaccines available?
Dr. Palese: Our government is rapidly developing vaccines and they are in the pipeline, but nothing has been approved as of today.
Dr. García-Sastre: Vaccines may be first available only on an experimental basis.