Rosalind J. Wright, MD, MPH
Building on its long history of groundbreaking science and advocacy in public health, and its research strengths in exposomics, genomic sciences, genetics, and big data analysis, the Icahn School of Medicine at Mount Sinai has established a Department of Public Health to address the urgent and mounting medical and environmental challenges of the 21st century.
Renowned physician and researcher Rosalind J. Wright, MD, MPH, was named Chair of the department and inaugural Dean for Public Health. Dr. Wright is Horace W. Goldsmith Professor and, most recently, the former Dean of Translational Biomedical Sciences at Icahn Mount Sinai. She is a founding Co-Director of the Institute for Climate Change, Environmental Health, and Exposomics, the nucleus of Icahn Mount Sinai’s work on studying environmental exposures and their effects on development, health, and disease across the life course.
Dr. Wright, who has authored or coauthored more than 350 peer-reviewed journal articles and delivered more than 150 regional, national, and international presentations, has long been committed to mentoring the next generation of public health scientists, having trained nearly 100 predoctoral and doctoral students and postdoctoral fellows over her career.
Bolstering these efforts is Icahn Mount Sinai’s extraordinary research capabilities, which include being ranked No. 4 among U.S. medical schools in National Institutes of Health (NIH) funding for Public Health, and No. 2 for Genetics (Blue Ridge Institute for Medical Research 2023 fiscal year), and No. 1 nationally in National Institutes of Environmental Health Sciences funding.
In the following Q&A, Dr. Wright discusses the transformative steps that will further strengthen Icahn Mount Sinai’s leadership in public health education, research, and practice.
Mount Sinai has been on the front lines of public health for decades. Why a Department of Public Health now?
We’re already widely recognized for our strengths in exposomics, genomic sciences, genetics, and big data analysis. And our public health research and advocacy work has frequently raised our national profile through studies, symposia, and testimony we’ve given before congressional committees looking into public health reform. By carefully assessing that repertoire of strengths—which often is the envy of others in the field—and bridging them, we can create a public health ecosystem that would allow our teams to cohesively share new knowledge, skills, and technology.
How, specifically, do you envision this?
Imagine if we could seamlessly marry the work of our environmental scientists in exposomics and genomics with the work of our computational and computer scientists. We could bring those data streams together even more than we are already doing and factor in our artificial intelligence and machine learning expertise to make sense of data patterns and profiles involving thousands of variables. The result would be revelations and gains in the field of public health not possible in the past.
How do you get there?
One of the ways we plan to set the stage for those breakthroughs is cross-training our students and workforce. Our goal is a transdisciplinary trained workforce so that MDs, PhDs, and other clinicians have the skills to understand climate science, for example, and to use data science methods, such as machine learning, to more precisely identify health-relevant environmental and genetic factors impacting all of our patients. Likewise, we want our data scientists to acquire the same basic skills in epidemiology and environmental health sciences to enable team science. Those ambitious goals will clearly require innovation and change around public health education at Mount Sinai.
We’ll be establishing doctoral programs in public health areas where our research and practice can lead the field, such as climate science and exposomics. But first, our plans are to expand our Master of Public Health programs to synergistically feed into planned doctoral programs. The public health programs were created in 2001 and are the oldest and largest graduate studies at Mount Sinai. We want our new department to be not just an academic home for investigators and public health practitioners, but an incubator for real curricula innovation.
We have what I see as a key advantage over other institutions in the field that will fortify our work: Mount Sinai Health System and Icahn Mount Sinai serve the greater New York City region, which includes East Harlem, an area of Manhattan that has one of the most diverse patient populations in the United States. It amounts to a laboratory rich in socioeconomic strata perfectly suited for research and clinical and public health practice. Just as importantly, we’ve advanced our science through programs like the BioMe®️ BioBank Program, with its tens of thousands of DNA samples driving genetic, genomic, and epidemiologic investigations, and through the Mount Sinai Million Health Discoveries Program, where we’ve woven genetics into real-world clinical care and have a goal to sequence 1 million Mount Sinai patients.
All of these approaches are essential if we are going to reinvent our response to the kinds of public health challenges we are seeing today—which are the same challenges we urgently need to address as a health system, too—climate change and environmental exposures of children within their communities, which we know can lead to asthma, obesity, learning disabilities, and much more. These will disproportionately impact communities that are already more burdened by these disorders. Nothing will focus us more as a department than gaining a more-informed understanding of the nature and impact of health-relevant environmental hazards that may contribute to health disparities in our communities.
You are building on a formidable legacy. What are the most impactful discoveries Mount Sinai researchers have made over the decades?
Uncovering the impact of asbestos on human health has been among the most consequential. Our work can be traced to Dr. Irving Selikoff, a pioneering researcher, who created in the 1960s the nation’s first hospital division of occupational medicine at Mount Sinai. His research on asbestos-related disease shaped public policy for working men and women around the world. It was also responsible for the landmark 1970 Occupational Safety and Health Act.
More recently, we’ve actively studied per- and polyfluoroalkyl substances (PFAS), the class of synthetic chemicals ubiquitous in the environment and our bodies. Our investigators have developed novel metrics to gauge our cumulative exposure to PFAS and have shown how that exposure is linked to significant reductions in female fertility, as well as child health outcomes, such as asthma. We’re proud that our science is now informing regulatory change around PFAS, undertaken by the Environmental Protection Agency in 2023.
My own lab has done considerable work with air pollution exposure. We were among the first to link that exposure to asthma onset, as well as to cognitive dysfunction in children in early life, and to show that this starts in utero and weighs disproportionately on low income and ethnic minority populations. We were also among the first with research to show that psychological stress in pregnant women puts their babies at higher risk of developing conditions like asthma, given the impact of stress on the immune system.
What excites you most about your new role?
My passion throughout my career has been public health—from the time I started my fellowship in pulmonary medicine and felt the sudden need to get a Master in Public Health degree. I realized that this knowledge would help me to better understand the disparities I was seeing in my asthma patients—disparities I knew couldn’t be explained by heritability or genetics alone, which led me to studying broad environmental influences as well. In the same way, I feel I’m now in a position to do something really unique as the new Dean for Public Health—to translate the scientific capabilities that we can collectively bring together to improve the health of our communities. And there’s no better place to accomplish that than at Mount Sinai.
Watch a video to learn more about the vision for Public Health at Icahn Mount Sinai.