A Special Lab Coat Ceremony Launches the Training of Future Scientists

The 56 members of the matriculating classes of PhD and MD/PhD students in the Graduate School of Biomedical Sciences at the Icahn School of Medicine at Mount Sinai received white lab coats during a special ceremony held Monday, September 9, in Goldwurm Auditorium.

“It is with great pride and joy that I welcome you,” Marta Filizola, PhD, Dean of the Graduate School, and the Sharon and Frederick Klingenstein/Nathan Kase, MD Professor of Pharmacological Sciences, and Professor of Neuroscience, told the students. “This ceremony serves as a symbolic induction to your professional PhD training in the Biomedical Sciences and Neuroscience programs, as well as to the MD/PhD Medical Scientist Training Program.” The Graduate School, which began the tradition in 2018, is the only institution in New York City, and one of a few in the nation, to honor its matriculating PhD classes in this manner.

Also receiving recognition were 43 PhD and MD/PhD students who have officially joined a lab and confirmed their PhD candidature by passing their thesis proposal exams. They were presented with honorary plaques.

The PhD students recited an oath to guide them through their training, and beyond. In part, they pledged to uphold the highest levels of integrity, professionalism, scholarship, and honor, and to conduct their research and professional endeavors with honesty and objectivity.

Eric J. Nestler, MD, PhD, Dean for Academic and Scientific Affairs, Director of The Friedman Brain Institute, and Nash Family Professor of Neuroscience, who was the event’s master of ceremonies, gave this advice to the students. “The most critical dimension of your graduate student career will be finding the right laboratory in which to do your dissertation research—and the most critical aspect of that choice will be the lab’s principal investigator, who will be your mentor,” he said. “I would argue that the lab principal investigator is more important to your future than the content of the lab’s work or the experimental approaches the lab utilizes. If it works as it should, your lab mentor will be one of your more significant relationships of your professional lives.”

When keynote speaker Francesca Cole, PhD, stepped to the podium, she almost immediately acknowledged her own mentor, Robert S. Krauss, PhD, Professor of Cell, Developmental and Regenerative Biology, and Oncological Sciences, at the Icahn School of Medicine at Mount Sinai, who was in attendance. Dr. Cole received a PhD in Biomedical Sciences in 2003 at Mount Sinai, followed by postgraduate training at Memorial Sloan Kettering Cancer Center, and today she is an Associate Professor of Epigenetics and Molecular Carcinogenesis at The University of Texas MD Anderson Cancer Center.

She outlined the struggles of a typical scientist. “We have to live with the knowledge that we could be wrong, that our approach may not work, that we may not be asking the right question. In short, doing research makes you feel stupid,” said Dr. Cole. “You must accept this. If you don’t feel that way, you aren’t working hard enough or pushing the boundaries of our knowledge enough.”

Dr. Cole also encouraged the students to select a mentor wisely and to support each other. “But this is my most important message to you,” she said. “It is abundantly clear that you all belong here. So, welcome to biomedical research, and let’s make beautiful science together.”

NYEE Residents Celebrate Commencement 2019

New York Eye and Ear Infirmary of Mount Sinai’s graduating residents, from left: Michael Chai, MD; Ekaterina Semenova, MD; Katherine McCabe, MD; Miel Sundararajan, MD; Anna Do, MD; Eileen Choudhury Bowden, MD; and Chris Wu, MD.

Seven residents and eleven fellows recently participated in the 2019 Commencement of the New York Eye and Ear Infirmary of Mount Sinai (NYEE).

James C. Tsai, MD, MBA, President of NYEE and System Chair of Ophthalmology at the Mount Sinai Health System and the Icahn School of Medicine at Mount Sinai, told the graduates, “Use your knowledge and skills to deliver exceptional and life-changing patient care. Lead changes in health care to enhance and transform the lives of patients in the communities you serve.”

The graduating residents will pursue their fellowship training at NYEE and other leading U.S. institutions, including the Bascom Palmer Eye Institute at the University of Miami, and the Shiley Eye Institute at the University of California, San Diego. Like the fellows who preceded them, the graduating residents will receive advanced training in subspecialties such as cornea and refractive surgery, glaucoma, ocular immunology, vitreo-retinal surgery, pediatric ophthalmology, and strabismus.

Beginning in 2021, NYEE’s ophthalmology residency programs will merge with The Mount Sinai Hospital’s (MSH) to become the nation’s largest, with 10 residents per year.

“The Mount Sinai Hospital and NYEE have long histories of excellence in education,” says Douglas R. Fredrick, MD, Deputy Chair for Education in the Department of Ophthalmology at the Mount Sinai Health System. “The integration of the two programs will take advantage of their unique strengths while providing trainees with unprecedented access to a wide range of patients and pathologies, as well as extensive resources that come from being part of a major academic medical center.”

In addition to training at NYEE and MSH, the residents will rotate through Elmhurst Hospital in Queens and the James J. Peters VA Medical Center in the Bronx.

Icahn School of Medicine at Mount Sinai Celebrates 50th Commencement

On Thursday, May 9, the Icahn School of Medicine at Mount Sinai celebrated its 50th Commencement with a ceremony at Lincoln Center’s David Geffen Hall. The School granted 157 degrees. Additionally, honorary degrees were granted to Commencement speakers, Scott Gottlieb, MD, and Curtis Martin. Dr. Gottlieb is the former Commissioner of the U.S. Food and Drug Administration. Mr. Martin, a National Football League Hall of Famer, has supported Mount Sinai’s efforts to develop a safe, non-addictive, non-opioid pain medication.

Advancing the Study of Dizziness and Imbalance

Joanna C. Jen, MD, PhD, a physician-scientist with a special interest in the genetic and physiological basis of neurological disorders affecting eye movement control, balance, and coordination, recently joined the Icahn School of Medicine at Mount Sinai as Chief of the Division of Neuro-otology and Neurogenetics in the Department of Neurology.

She was named the Dr. Morris B. Bender Professor of Neurology, and Professor of Neurosurgery, and Otolaryngology, and will build upon the groundbreaking work of her predecessors—the late Morris B. Bender, MD, a pioneer in the neurology of the ocular motor system and a former Chair of Neurology at Mount Sinai, and Bernard Cohen, MD. An internationally renowned scientist and clinician, Dr.  Cohen considerably advanced understanding of the functions of the vestibular system, helping to discover a mechanism in the brainstem that is an essential part of the neural basis for balance that aligns the body with gravity.

In one research project that began in the 1980s—which was recently documented in the Smithsonian Institution Online Virtual Archives Dr. Cohen was asked by NASA to test the neuro-optical response of primates when orbiting the Earth in microgravity. The Cosmos Primate Rotator Chair, which was built to specifications provided by Dr. Cohen and a Russian Academy of Medicine scientist, allowed the researchers to study eye movement responses in monkeys in an upright position and at various angles of tilt, before and after spaceflight. They demonstrated for the first time that exposure to microgravity had dramatically altered an essential reflex that is part of normal eye movements, both in humans and monkeys.

Dr. Cohen with the Cosmos Primate Rotator Chair.

The laboratory established by Dr. Cohen also developed the first effective treatment for mal de débarquement syndrome (MdDS), which has since treated more than 400 patients who have sensations of continuous rocking, swaying, and bobbing after cruises on the sea. Dr. Cohen, who served as the inaugural Dr. Morris B. Bender Professor of Neurology and continues his research as Professor Emeritus, recently provided generous funding for the first fellow in neuro-otology and for research on the pathophysiologic mechanisms underlying MdDS.

In her new role, Dr. Jen aims to create a comprehensive multidisciplinary clinical care and research program that spans the population health approach, from front-line evaluation and management of dizziness and imbalance, to precision medicine-based diagnosis and treatment for rare disorders of cerebellar maldevelopment and degeneration.

Fourth Annual Mount Sinai Innovation Awards

Anne Schaefer, MD, PhD, Inventor of the Year

Individuals and teams from the Mount Sinai Health System were honored for significant advances in research, technology, medicine, and health care at the fourth annual Mount Sinai Innovation Awards ceremony, which was held Monday, October 22, in conjunction with the SinaInnovations conference.

Anne Schaefer, MD, PhD, Associate Professor, Neuroscience, and Psychiatry, at the Icahn School of Medicine at Mount Sinai, and a
Seaver Fellow at The Friedman Brain Institute, received the Inventor of the Year Award for her work in micro-RNA, which heralds a potential cure for intractable seizures in certain forms of epilepsy, including Dravet syndrome, a catastrophic childhood disease.

Julio A. Aguirre-Ghiso, PhD, left, recipient of the Deal of the Year Award, with Scott L. Friedman, MD, Dean for Therapeutic Discovery, and leader of the SinaInnovations conference.

Julio A. Aguirre-Ghiso, PhD, Professor, Medicine (Hematology and Medical Oncology), Otolaryngology, and Oncological Sciences, received the Deal of the Year Award for his research into the underlying causes of metastatic disease and relapse that is the basis for a new startup company in New York City.

Drew Kiraly, MD, PhD, and James Young, MD, PhD, received the Faculty Idea Prize for analyzing more than 1,000 metabolites from the serum of patients undergoing active monitoring for epileptic seizure activity. The analyses of Dr. Kiraly, Assistant Professor, Neuroscience, and Psychiatry, and Dr. Young, an Instructor in Neurosurgery and Neurology, will serve as the first step in developing clinically applicable serum biomarkers to help refine and target treatment strategies for epilepsy.

A group of 22 innovators received the 4D Technology Development Program Award for five projects that efficiently move new technologies through a process of discovery, design, development, and delivery:

• Identification of biomarkers for preemptive diagnosis of ocular graft vs. host disease (oGVHD) in patients with hematopoietic cellular transplantation (HCT): Penny A. Asbell, MD; Neeta S. Roy, PhD; James L. Ferrara, MD, DSc; John E. Levine, MD; Eric Kuklinski, BS; and Yi Wei, PhD.

• Automation of radiographic measurements for surgical planning using artificial intelligence: Samuel K. Cho, MD; Varun Arvind, BS; Deepak Kaji, BA; Jun S. Kim, MD; Eric K. Oermann, MD; and Jonathan E. Robinson, MD.

• Development of an epigenetic treatment for Prader-Willi syndrome: Jian Jin, PhD; Yong-Hui Jiang, MD, PhD; and Yan Xiong, PhD.

• Creation of an eye-tracking algorithm for autism: Pilar Trelles, MD; Robert Gilman, MD; Alexander Kolevzon, MD; and Mirko Zimic, PhD.

• Knowledge-based automated radiotherapy planning via deep learning: Yading Yuan, PhD; Yeh-Chi Lo, PhD; and Tzu-Chi Tseng, MS.

The Dean’s Healthcare System Team Science Award, which acknowledges the importance of interdisciplinary teams in translational research, went to 15 members of the DEFINE-FMD Team. The group initiated a large, functional omics study of the genetic and molecular basis of fibromuscular dysplasia (FMD), a disease that predominately affects women and results in stroke and myocardial infarction. The study has enabled the team to identify several disease-causing candidates and begin developing a blood-based diagnostic test. The winners were Jason Kovacic, MD, PhD; Jeffrey W. Olin, DO; Antonio F. Di Narzo, PhD; Valentina d’Escamard,
PhD; Daniella Kadian-Dodov, MD; Haoxiang Cheng, PhD; Annette King, RN, ANP; Bhargravi Vonguru, MS; Emir Bander, MD; Allison Thomas, MS; Rihab Bouchareb, PhD; Sander Florman, MD; Johan LM Björkegren, MD, PhD; Manuel Mayr, MD, PhD; and Ke Hao, PhD.

Four individuals received Trainee Innovation Idea Awards, which highlight research ideas from Mount Sinai trainees that could potentially be translated into a marketable product:

• MD student Aly Valliani: Virtual Contrast

• PhD student Billie Bian: MediTrack

• Postdoctoral fellow Sangeetha Vadakke- Madathil, PhD: Placental stem cells for regeneration of an injured heart

• House staff physician Jorge Andrade Romo, MD: Structural vs. functional foveal avascular zone (FAZ) parameters compared at different stages of diabetic retinopathy.

Corporate sponsors for SinaInnovations included Altice Business; Cisco Systems; Dell Technologies; Fisher Scientific; Gilead Sciences; Jones Day; and the Louis and Rachel Rudin Foundation. Health Hackathon sponsors included Persistent Systems.

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