Updated on Jun 30, 2022 | Research
Bruce D. Gelb, MD
An exciting development in birth defects research emerged in 2015! In 2013, Gabriella Miller, a young girl dying from cancer, called upon the U.S. Congress for “less talking, more doing…We need action.” This stimulated Congress to pass the Gabriella Miller Kids First Research Act in 2014, which authorized $12.6 million/year for 10 years toward pediatric research. In implementing this mandate, the National Institutes of Health (NIH) decided to use the 2015 funds for performing whole genome sequencing (WGS) for certain childhood cancers and, of relevance here, for structural birth defects. (more…)
Updated on Jun 30, 2022 | Inside, Research, School
Joseph D. Buxbaum, PhD
Joseph D. Buxbaum, PhD, a pioneering researcher in the field of autism, recently was elected to the National Academy of Medicine, considered one of the highest honors in medicine. New members are elected annually by current active members through a selective process that recognizes individuals who have made major contributions to advance medical sciences, health care, and public health.
A world-renowned molecular geneticist and neurobiologist, Dr. Buxbaum is Professor and Vice Chair for Research in the Department of Psychiatry, and Director of the Seaver Autism Center for Research and Treatment at Icahn School of Medicine at Mount Sinai. He is also Professor of Neuroscience, and Genetics and Genomic Sciences, and the G. Harold and Leila Y. Mathers Research Professor of Geriatrics and Adult Development. (more…)
Updated on Jun 30, 2022 | Research
Previous studies have shown that there is a clear relationship between physical activity and higher bone mineral density (BMD). Exercise and the force that muscle contraction applies to bone improve skeletal health by stimulating the formation of new bone. Conversely, off-loading muscle, such as in astronauts, can lead to bone loss and an increased fracture risk. But the question of how muscle function regulates bone mass has remained largely unresolved despite their close anatomical proximity. A key question is whether muscle contraction connects to bone mass regulation through a secreted molecule. (more…)
Nov 20, 2015 | Inside, Research
Mark Lebwohl, MD
The results of a multicenter clinical trial led by Mount Sinai Health System researchers and published in The New England Journal of Medicine on October 1, 2015, demonstrate that brodalumab, an experimental biologic treatment for plaque psoriasis, achieved 100 percent reduction in psoriasis symptoms in twice as many patients as a second, commonly used treatment. (more…)
Oct 20, 2015 | Inside, Research
The Department of Anesthesiology at the Mount Sinai Health System
Repeated exposure to anesthesia early in life causes changes in emotional behavior that may persist long-term, according to new research from the Icahn School of Medicine at Mount Sinai.
The findings, published in the August 2015 Online First edition of Anesthesiology, mark the first time nonhuman primates have been found to experience long-term behavioral changes resulting from repeated postnatal exposure to anesthesia. Prior results have shown that baby rodents also experience cognitive impairments later in life stemming from early anesthesia exposure. (more…)
Oct 8, 2015 | Inside, Research
Leticia Tordesillas, PhD
Leticia Tordesillas, PhD, and Elizabeth Heller, PhD, are the recipients of the 2015 Robin Chemers Neustein Postdoctoral Fellowship Award, which was created to encourage and support female research scientists at Icahn School of Medicine at Mount Sinai.
Dr. Tordesillas works in the laboratory of Cecilia Berin, PhD, Associate Professor of Pediatrics. Her research is focused on how to establish immune tolerance to foods for the treatment of food allergy. In particular, she is studying how regulatory T cells induced by epicutaneous immunotherapy are generated and suppress anaphylaxis. (more…)
