Mount Sinai and Sema4 Launch Groundbreaking Asthma Study With Global Pharmaceutical Company

Andrew Kasarskis, PhD, left, and Linda Rogers, MD, are part of the asthma study team.

Asthma, a chronic disease of the airways of the lungs, is a growing public health problem that now affects 350 million people and results in about 400,000 deaths worldwide each year. Its diagnosis and treatment remain challenging, however, and debilitating symptoms, such as coughing and shortness of breath, are a major cause behind rising health care costs, missed school for children, and loss of productivity and early disability in adults.

Recently, the Mount Sinai Health System and Sema4—a patient-centered predictive health company and a venture of Mount Sinai—joined with Sanofi, one of the world’s largest pharmaceutical companies, to follow 1,200 Mount Sinai patients to gain unprecedented insights into the biological mechanisms and environmental factors implicated in this condition.

The five-year study—the first of its kind—will collect traditional clinical data, such as electronic medical records and clinical samples, including blood samples and nasal brushings, from  patients during their doctor appointments. The data will be analyzed for genomic and transcriptomic information and combined with other data collected using the patient’s mobile phone—environmental data, like air quality and pollen counts, data from the patient’s asthma inhaler, and data from home monitoring of activity and sleep. One of the unique elements of this study is that the research will be incorporated into actual clinical practice, and real-world data using remote devices will be integrated with molecular data.

“Despite advances in recent years, we still see many patients struggling with asthma, so there is a tremendous need for innovation to reduce the burden of this disease,” says Linda Rogers, MD, Associate Professor of Medicine (Pulmonary, Critical Care and Sleep Medicine) and Clinical Director of the Adult Asthma Program at the Mount Sinai – National Jewish Health Respiratory Institute. Dr. Rogers is the clinical principal investigator of the study, which is a collaboration among the Respiratory Institute, the Icahn Institute of Genomics and Multiscale Biology, Sema4, and Sanofi.

The Respiratory Institute is uniquely positioned to undertake this research. In addition to the large number of asthma patients that the program treats, the Mount Sinai and Sema4 study team have unparalleled capabilities in specimen analysis, data science, and multiscale biological modeling, allowing researchers to gather large amounts of data more rapidly than using more traditional research methods.

Clinical research teams will deploy advanced analytics on this information to better understand how the disease functions, including what triggers asthma attacks and which patient segments are most likely to respond to certain therapies. “This collection of large amounts of multiple types of data is needed to fully understand asthma—a condition researchers now believe is far more complex than was previously understood—and how best to treat patients,” says Tom Neyarapally, Sema4’s Chief Commercial Officer.

Significantly, gathering and analyzing these kinds of data from patients will demonstrate at the molecular level how their bodies are responding to asthma, says Andrew Kasarskis, PhD, Executive Vice President and Chief Data Officer for the Mount Sinai Health System and a co-principal investigator of the study. For example, analysis of a blood sample will show changes in the cellular activity, such as which proteins are being produced, and a nasal swab may reveal important clues about one’s immune response and what is happening in the lungs.

“We will define asthma subtypes clinically, then understand the molecular basis of disease in each subtype in order to discover new therapies and better manage asthma in all our patients,” says Dr. Kasarskis.

Ultimately, adds Erik Lium, PhD, Executive Vice President of Mount Sinai Innovation Partners, “this collaboration may lead to the identification of novel drug targets and the development of groundbreaking therapies to benefit all patients with asthma.”

 

A New Waiting Room that Supports Men’s Health

The idea that men often take better care of their cars than their own health led to the recent opening of a sports-themed waiting room at the Milton and Carroll Petrie Department of Urology’s midtown office at 625 Madison Avenue. The special space was designed to serve as a refuge for male patients waiting for a doctor’s appointment or looking for
educational resources on prostate health or men’s health.

Amid the mounted football jerseys belonging to former Super Bowl winners and other framed sports memorabilia featured in the room, male patients can find information on medical services, holistic treatments, or emotional support when dealing with a critical prostate diagnosis.

Ash Tewari, MBBS, MCh, left, and Tom Milana Jr. celebrated the opening of the waiting room with a ribbon-cutting.

The new space was donated by Man Cave Health, Inc., a nonprofit led by philanthropist and Mount Sinai Health System patient Tom Milana Jr., a prostate cancer survivor who recognized the need to raise awareness about the disease and men’s health as he was recovering from his 2016 diagnosis.

At the official ribbon-cutting ceremony in January, Mr. Milana said, “This is a place where men can get educated, screened, and treated for prostate cancer in a welcoming environment. Our goal is to get more men to go to the doctor for their annual screening, which will lead to fewer prostate cancer deaths in this country.”

Mr. Milana’s physician at Mount Sinai, Ash Tewari, MBBS, MCh, the Kyung Hyun Kim, MD Chair in Urology, said, “Men avoid going to the doctor. I think this room makes a difference. They can come here and relax.”

The inspirational message, he added, is about winning at sports and winning the fight against cancer.

Good Morning America Features Young Mount Sinai Kidney Patient’s ‘Medical Miracle’

Doctors at Mount Sinai Kravis Children’s Hospital have performed a ‘medical miracle’ on eight-year-old Lexi. Born without a bladder and with both kidneys blocked, she first underwent surgery at age six so doctors could create an artificial bladder. In January she received a kidney transplant, with her father as the donor.

Watch the video on Good Morning America  

Panel on Palliative Care Shines a Light on Caregivers

From left: R. Sean Morrison, MD, moderator of the “Partners in Care” event, with panelists Elizabeth Gilbert; Jennifer Homans, PhD; Cardinale Smith, MD; and Michael Ausiello—who each cared for a seriously ill loved one.

They spend an average of 20 hours a week in an unpaid, emotionally draining job. One in three is in poor health, and 97 percent say they need more help. Who are they? They are the 65 million Americans who provide care to an adult relative at home, and a panel discussion called “Partners in Care” was held on Monday, November 5, to shine a light on their experience.

“When we think about health policy, when we think about medical coverage, we always think about the patient who is living with serious illness, and we forget their caregivers. They need help, as well,” said the moderator of the panel, R. Sean Morrison, MD, the Ellen and Howard C. Katz Chair of the Brookdale Department of Geriatrics and Palliative Medicine at the Icahn School of Medicine at Mount Sinai.

The panel was held at the Lotos Club in Manhattan, one of the nation’s oldest literary clubs, and it consisted of three noted authors who had each cared for a seriously ill spouse or partner: Elizabeth Gilbert (author of Eat, Pray, Love); Michael Ausiello (author of Spoiler Alert: The Hero Dies); and Jennifer Homans, PhD (author of Apollo’s Angels: A History of Ballet); along with Cardinale Smith, MD, Associate Professor of Medicine (Hematology and Medical Oncology), and Geriatrics and Palliative Medicine, who cared for her father when he was dying of cancer. The event was sponsored by longtime Mount Sinai donors Margery and Stephen Riker.

Ms. Gilbert told the story of caring for her partner, Rayya Elias: “This was an incredibly powerful person, even though she was 87 pounds,” who decided to move out of hospice to live near friends in Detroit just months before she died in January 2018 of pancreatic cancer. Ms. Gilbert called her years as a caregiver “the most brutal, beautiful experience of my life.”

Dr. Homans spoke of trying to write a book, raise her children, and care for her husband, who was living with amyotrophic  lateral sclerosis (ALS). “Palliative care meant introducing someone else who could stand with us among all those whirling parts—this third person who was calm and knowledgeable and could steady the ship for a moment.”

Palliative care focuses on treating the symptoms, pain, and stress of a serious illness for patients and their families. It is appropriate at any age and at any stage in a serious illness, and unlike hospice, it can be provided alongside curative and all other appropriate medical treatments. “It truly is whole-patient care, and we offer the same support for loved ones,” Dr. Smith said.

The nation is headed for a shortage of caregivers, Dr. Morrison said, adding that “2030 is an important number in health care.” That is the year when, for the first time in history, there will be more people in the world who are 65 and older than people who are under 21. Increased public awareness and health policy reform will help alleviate the caregiver shortage and burden, he said. The Brookdale Department, which hosted the “Partners in Care” event, strives to advance this conversation, and to support seriously ill people and their caregivers through multifaceted work, from clinical care, to training doctors, to pursuing research.

“There is no coverage for caregivers in our nation’s health system, and that is fixable,” Dr. Morrison told the audience. “That means asking your local representative to make it an important policy issue. Become involved in one of your palliative care organizations, become a voice, and become active.”

Patient Reimagines Her Surgery as Art

Artist Frances McGuire transformed the arduous experience of multiple knee surgeries into creative inspiration by sketching serious, and sometimes whimsical, images of the experience.

Now, the lively prints are on display at the Orthopedic Center and the surgery waiting room at Mount Sinai West, thanks to Michael J. Bronson, MD, Chair of Orthopedics at Mount Sinai West and Mount Sinai St. Luke’s, who performed each of Ms. McGuire’s surgeries, and Evan L. Flatow, MD, President, Mount Sinai West.

Ms. McGuire created the sketches during a months-long recovery in which she was unable to paint in her studio. Each piece was crafted using a drawing app on her iPad. “It was extremely therapeutic,” Ms. McGuire says of making her sketches. “I loved the energy of doing them, and I love sharing them.”

“Fabulous and Fighting” Brings Fashion to Cancer Patients

Executive Director, Bethany Heinrich, left, with Sandy Lansinger, Patient Navigator at The Blavatnik Family – Chelsea Medical Center at Mount Sinai.

Patient Inez West models her selections from Fabulous and Fighting

More than 30 patients from the Women’s Cancer Program at The Blavatnik Family – Chelsea Medical Center at Mount Sinai attended a designer clothing “pop-up shop” on Friday, October 12, sponsored by the nonprofit group Fabulous and Fighting.

At the event, each woman picked out two free items of clothing donated by fashion houses in the New York City area and received free books and journals on breast cancer.

Fabulous and Fighting was created after Bethany Heinrich, Executive Director and Co-Founder, helped her mother navigate cancer treatments and noted that as patients’ weight fluctuated, they had trouble affording new, fashionable clothes that fit.

The nonprofit aims to empower women and boost their confidence as they face the challenges of cancer.

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