Making Sense of the Pandemic Now

If you are fully vaccinated, are you protected from COVID-19? Will we need booster shots? What is the best way to keep children safe as they return to school?

These and other pressing questions were discussed in an Aspen Ideas Festival virtual event, in which Kenneth Davis, MD, MD, President and Chief Executive Officer of the Mount Sinai Health System, interviewed Judith A. Aberg, Dean of System Operations for Clinical Sciences, and Chief of the Division of Infectious Diseases, and Harm van Bakel, PhD, Assistant Professor of Genetics and Genomic Sciences and a leader of Mount Sinai’s Pathogen Surveillance Program. The interview, which was released in July, can be viewed here.

Dr. Aberg, who leads Mount Sinai’s COVID-19 clinical trial efforts, shared a favorite analogy about the vaccines’ effectiveness: “An umbrella will keep you dry for the most part, but you can still get wet in a bad storm,” she said. In the same fashion, “the current vaccines are highly effective even for the circulating variants, but we do expect there will be breakthrough infections in some individuals. So I encourage everyone to get vaccinated.”

What You Need to Know About Heart Inflammation and the COVID-19 Vaccines

A woman talking to her young male patient in medical office

Researchers at the U.S. Centers for Disease Control and Prevention (CDC) are investigating a link between COVID-19 vaccines from Pfizer-BioNTech and Moderna and heart inflammation in young men and boys.

Kristin Oliver, MD, MHS, a pediatrician and preventive medicine physician at the Mount Sinai Health System and an Assistant Professor of Pediatrics, and Environmental Medicine and Public Health, at the Icahn School of Medicine at Mount Sinai, explains what parents, guardians, and young adults need to know about this rare side effect.

What is the situation as you see it?

The COVID-19 mRNA vaccines from Pfizer-BioNTech and Moderna have been linked to cases of myocarditis, which is an inflammation of the heart, and pericarditis, which is inflammation of the sac-like covering around the heart. Myocarditis and pericarditis can happen after an infection from different viruses, including SARS-CoV-2—the virus that causes COVID-19. They are more commonly seen in males.

How common is this side effect?

Myocarditis and pericarditis can be serious but, fortunately, these side effects to vaccination are very rare. While we don’t know the precise rate of these side effects in relation to COVID-19 vaccines, we do know that it is more commonly seen in men and boys and after the second dose of the vaccine. Signs of myocarditis and pericarditis tend to become visible within four days of the vaccine dose.

Keep in mind that as of July 2021, more than 52 million doses of the COVID-19 vaccines have been administered in the United States to people ages 30 or younger, and the CDC has only confirmed about 600 reports of myocarditis or pericarditis in connection with vaccination in this age group. The cases connected to receiving the COVID-19 vaccine have also been mild. So, the benefits of COVID-19 vaccination in this group still outweigh the risks of getting myocarditis from the vaccine.

What are the signs of myocarditis/pericarditis?

People with heart inflammation experience chest pains, difficulty breathing, heart palpitations, and excessive sweating. These symptoms may also be accompanied by stomach pain, dizziness, coughing, unexplained swelling, and even fainting. If a recently vaccinated person shows symptoms of myocarditis or pericarditis, they should seek medical attention.

The most common side effects from COVID-19 vaccination are pain at the injection site, fatigue, headache, fever, chills, muscle pain, or joint pain. These vaccination side effects can be managed with over-the-counter medication and rest.

What do you say to families who are concerned about this serious, but rare, side effect?

I’m honest with families when I talk about it, and I understand that it’s disappointing to learn about this connection. But because it happens so rarely and because COVID-19 infection can have serious consequences in adolescents and young adults, the benefits of vaccination still outweigh the risks.

In making any medical decision we are weighing the potential risks and benefits. Remember, the risks of COVID-19 infection in this age group are real and so are benefits of COVID-19 vaccination. Data from the CDC estimate that if we vaccinate one million males between the ages of 12 and 17, we will prevent: 5,700 cases of COVID-19, 215 hospitalizations, 71 ICU stays, and 2 deaths in this group.

But I always recommend that parents talk with their pediatrician about any concerns. Pediatricians know what’s important to you and your family and have lots of experience giving vaccines and answering these questions.

Pandemic’s Toll on Mount Sinai Front-Line Staff Is Surveyed, and Addressed

Recharge rooms were created across the Health System in one of many initiatives informed by surveys of front-line staff.

Front-line staff who were already feeling burnout showed the most signs of mental distress during the height of the COVID-19 pandemic, while those who fared best had an active social network and felt supported by their supervisors. These were among the many lessons learned by a team of Mount Sinai researchers based on two surveys of front-line Mount Sinai staff in 2020.

“The main takeaway is what most people would expect—that if you’re involved in health care during a pandemic, it’s going to take its toll,” says Jonathan Ripp, MD, MPH, Dean for Well-Being and Resilience and Chief Wellness Officer at the Icahn School of Medicine at Mount Sinai. “But beyond that, we were able to identify what types of things may put you at greater or lesser risk of these mental health outcomes, and inform how we can try to mitigate them.”

The results were used in real time to develop programs to help Mount Sinai staff handle the pressures of the pandemic, Dr. Ripp says, and they are being shared with other institutions through journal publications and a Well-Being Toolkit developed by the Office of Well-Being and Resilience.

The three mental health outcomes studied were depression, anxiety, and post-traumatic stress disorder related to the COVID-19 pandemic. Among the more than 3,000 front-line staff members who responded to an initial survey in April and May 2020, 39 percent screened positive for at least one of these outcomes. The most significant factor predicting mental health symptoms was the presence of pre-pandemic burnout, according to studies published by the Mount Sinai team in The Journal of Clinical Psychiatry and Chronic Stress.

At the start of the pandemic, Mount Sinai focused on meeting the basic needs of front-line staff, such as providing free or subsidized food onsite.

“This means that if you already felt exhausted, fatigued, and detached from your work, you were more likely to develop these mental health symptoms during the pandemic,” says investigator Lauren Peccoralo, MD, MPH, Senior Associate Dean for Faculty Well-Being and Development, and Associate Professor of Medicine at the Icahn School of Medicine at Mount Sinai. The research team emphasized that burnout is distinct from other mental health issues in that it is more a function of the work environment, and can be remedied by strategies that support workers.

In the earliest days of the COVID-19 pandemic, the Office of Well-Being and Resilience assembled a group of researchers with backgrounds in psychology, psychiatry, survey design, and statistical analysis to examine its mental health consequences on the workforce, in an effort initiated by Dennis S. Charney, MD, Anne and Joel Ehrenkranz Dean, Icahn School of Medicine at Mount Sinai, and President for Academic Affairs, Mount Sinai Health System.

The group sent surveys to more than 6,000 physicians, nurses, social workers, chaplains, and other front-line staff at The Mount Sinai Hospital during the height of the pandemic’s first wave in April and May 2020 and again seven months later. In the first survey, more than 3,000 respondents answered questions from three diagnostic series: the General Anxiety Disorder 7, the Personal Health Questionnaire 8, and the Post Traumatic Stress Disorder checklist. In the self-screening for depression, for example, about 26 percent of respondents reported that on more than half the days of the week, they felt such symptoms as taking little interest or pleasure in doing things, feeling hopeless, losing their appetite, having trouble staying or falling asleep, or difficulty concentrating.

The survey also asked open-ended questions about the respondents’ concerns. “There were a lot of infection-related worries. People were worried about PPE, about infecting colleagues or bringing COVID-19 home to their family members,” says Jordyn Feingold, MD, an investigator in the study, who graduated from Icahn Mount Sinai in May 2020 and is now a psychiatry resident. “There were worries about basic needs like getting food at work, and existential worries like ‘When is this going to end?’ and ‘When is life going to return back to normal?’”

The aid facilitated by the research team fell into three categories: providing basic needs like food and the proper personal protective equipment (PPE) and other materials; providing up-to-date information through channels including web sites and system-wide email broadcasts; and creating well-being spaces and onsite mental health and peer support to reduce the stress experienced by health care workers.

A Second Survey Finds an Increase in Burnout

The surveys also asked questions related to resilience, Dr. Ripp says. Specific factors that were found to be protective against mental health symptoms included getting enough sleep and exercise, having social emotional support, not using substances to cope, having sufficient PPE, and feeling supported by hospital leadership and valued by supervisors.

Simply feeling heard was also important, Dr. Feingold says. “Whether or not we have it in our control to fix all of these things right away,” she says, “just validating the concerns and letting people know that they’re not experiencing this in isolation, I think was really powerful.”

In the second survey, conducted from November 2020 to January 2021, more than 1,600 responded and of those, 786 staff provided follow-up responses on their mental health and well-being. The results indicate that mental health symptoms have declined, but the prevalence of burnout has increased, Dr. Peccoralo says. “We are still analyzing the data, but one thought is that the traumatic situation has largely gone away, but the work hasn’t. We’re all still working really hard, maybe even harder than we have ever worked before,” she says. “So we have to think about how we can tell if we are pushing people too much, and what we can do about it.”

The surveys have served an important role in helping Mount Sinai take care of its own, and in advancing knowledge of the mental health consequences of responding to a pandemic, Dr. Ripp says.

The needs identified in the surveys have informed the development of new initiatives, including the launch of the Center for Stress, Resilience, and Personal Growth, says its Clinical and Research Director, Jonathan DePierro, PhD, Assistant Professor of Psychiatry at the Icahn School of Medicine at Mount Sinai. The Center is an innovative service supporting the resilience and psychological health of all Mount Sinai faculty, staff, and trainees through a series of evidence-based resilience workshops, a resilience-promoting app available for download on Sinai Central, ongoing outreach efforts, and up to 14 treatment sessions in its confidential faculty practice.

“Let’s hope that it’s a very long time before something like this pandemic happens again, but should it happen, I think the lessons that we’ve learned can apply,” Dr. Ripp says. “And then of course we can share those lessons, so that other institutions that haven’t had the opportunity to study this trajectory can learn from our experience.”

What Is the Delta Variant and Why Is It a Concern for Those Who Are Not Vaccinated

One of the latest terms to emerge from the pandemic is the Delta variant. This variant appears to be more contagious than previous variants and has become more common in the United States.

In this Q&A, Sean Liu, MD, PhD, an Assistant Professor of Medicine (Infectious Diseases) at the Icahn School of Medicine, says the spread of this variant is concerning because of the number of people who remain unvaccinated.  Those who become infected with this variant pose an elevated risk to household members who are not vaccinated and to others they come in contact with, such as those with compromised immune systems—which includes those with chronic medical conditions and the elderly—who are not able to fight infections as easily as most. Dr. Liu is part of the team of experts at Mount Sinai who are at the forefront of research into vaccines and who are also on the front lines treating patients and helping to limit the spread of the virus in the New York metropolitan area.

Sean Liu, MD, PhD

What is the Delta variant?

All viruses, including the SARS-CoV-2 virus that causes COVID-19, will evolve over time. It is normal for a virus to change a little bit when it makes copies of itself, or replicates. These changes are called mutations. The virus with one or more new mutations is referred to as a variant. Genetic variants of SARS-CoV-2 have been emerging and circulating around the world throughout the COVID 19 pandemic. There are six variants of concern circulating in the United States; the Delta variant is one of these circulating variants. The Delta variant was first detected in December 2020, and recently this variant has been detected in more than 80 countries, and in all 50 states.

Why is there a concern over this variant?

The variants of concern show evidence of at least one of the following five properties:

  • The variant may spread more easily from person to person.
  • The variant may lead to more severe disease, including increased hospitalizations or deaths.
  • The variant may be significantly harder to combat by antibodies generated during a previous infection or vaccination.
  • Treatments or vaccines may show reduced effectiveness against the variant.
  • The variant may evade diagnostic detection.

The Delta variant, specifically, has three of these properties, one being increased transmissibility. There is a 1.6-fold increase in the odds of household transmissions for the Delta variant compared with the Alpha variant, also known as the UK variant.

Why is the issue of transmissibility so important?

The fact that this strain can spread so quickly means is that you have a higher likelihood of spreading the Delta variant if infected. As clinicians, we see a lot of COVID-19 spread throughout families. It’s very devastating among households, and this variant specifically has this increased transmissibility within a household. People who are unvaccinated are really putting their family members, or those in their household, at increased risk for severe disease, especially if they too are unvaccinated.

For those who are fully vaccinated, does the Delta variant pose a risk?

It is important to remember that the goal of the COVID-19 vaccines is to prevent severe infections, hospitalizations, and deaths.  The mRNA-based vaccines are about 95 percent effective against hospitalization for COVID-19, with either one or two doses. Studies suggest that the Pfizer-BioNTech vaccine reduced the odds of symptomatic disease from the Delta variant, which means getting mildly sick, by 36 percent after one dose and 88 percent after two doses. There is, however, no available data about asymptomatic or mild infections with the Delta variant in fully vaccinated people, which means that people can get infected but not show any symptoms. Also, we know that people with underlying medical conditions have died from COVID-19, even after being fully vaccinated. As a result, the Delta variant creates a major concern if there are fully vaccinated people who are in close contact with family or household members or with people who are immunocompromised or have not been vaccinated, including children.

What about those who are not vaccinated?

If you have not been vaccinated yet, you should seriously consider doing so now.  People who have not been vaccinated have a much greater risk of getting seriously ill or dying from COVID-19, especially the Delta variant. Meanwhile, people who are not vaccinated, or who are immunocompromised, should continue to use masks, socially distance to avoid infection especially if you don’t know the status of the individuals around you. If you’re unsure of getting vaccinated, I would encourage you to have discussions with medical professionals who may provide reliable information about the benefits of vaccination. Currently, 44 percent of New York City residents of all ages have not been vaccinated and 34 percent of adults have not been vaccinated in New York City. The distribution of people getting vaccinated is not even. Check out the New York City Department of Health website for the latest information about vaccine availability and vaccination rates.

Why are vaccines important?

The COVID 19 pandemic is a global problem. While vaccines are becoming readily available in the United States, the majority of the world remains unvaccinated. And the pandemic will persist for months, and likely years. Vaccination is our primary means of ending the pandemic. Vaccines are safe and effective. Please consider getting vaccinated, if you are eligible.

 

Can the COVID-19 Vaccines Affect My Fertility?

Worried young woman holding pregnancy test

Some men and women may be reluctant to get the COVID-19 vaccination because of concerns about fertility. You may be wondering if any of the vaccines used in the United States can have an effect on your sperm count, or on your eggs, embryo, or the pregnancy itself.

In this Q&A, Alan Copperman, MD, Director of the Division of Reproductive Endocrinology and Infertility and Vice Chair of the Department of Obstetrics, Gynecology, and Reproductive Science at the Mount Sinai Health System, says the evidence shows that the vaccines do not pose a concern.

Update: The Centers for Disease Control and Prevention on September 29, 2021, strongly recommended COVID-19 vaccination either before or during pregnancy because the benefits of vaccination outweigh known or potential risks. Read more from the CDC

Does the COVID-19 vaccine affect my sperm count?

None of the COVID-19 vaccines in use in the United States affect sperm count or the sperm’s  ability to move toward an egg (motility). It is true that contracting a severe case of COVID-19 can lower sperm count for a time. But studies show that the vaccine itself does not affect sperm. In fact, we recently completed a study looking at sperm donors around the country before and after getting the vaccine. We saw no change in count or motility.

Can the vaccine affect my ability to get pregnant and have a baby?

We have found that the COVID-19 vaccinations do not affect a woman’s fertility.  Pregnancy involves a number of steps:

  • Your ovaries release an egg.
  • The egg travels through the fallopian tube to the womb (uterus).
  • Sperm fertilizes the egg as it travels.
  • The fertilized egg attaches to the inside of the uterus (implantation) and grows.

A problem at any one of these steps can lead to infertility. We’ve been studying women who have gone through several fertility cycles to see if any of the COVID-19 vaccines used in the United States affects any of these steps. We have found that:

  • The vaccine does not decrease egg production.
  • It doesn’t affect the ability to make an embryo.
  • It doesn’t affect a chromosomally normal embryo’s ability to grow in the uterus.
Will the COVID-19 vaccine have any effect on my pregnancy?

This is a good question because we’ve found that pregnant women who get COVID-19 tend to become very ill. That’s why we recommend taking the vaccine. As of now, three billion COVID-19 vaccinations have been administered, have of them to women, and we haven’t heard any reports of them affecting a woman’s pregnancy. We have also seen women getting the vaccine while undergoing in vitro fertilization—and it has had no effect on their outcomes. In fact, we have found that the vaccine not only protects the pregnant woman, but it keeps them safe at vulnerable times, such as when they deliver—and the fetus gets some immunity as well. We hypothesize that the vaccine prevents severe illness in these babies.

Should I get the COVID-19 vaccine if I’m planning a pregnancy in the near future?

The best time to get the vaccine is as soon as it becomes available to you. You may feel tired after the shot, and you may have short-term symptoms like fever. Some people have an allergic reaction to the vaccine, but that is very rare. We definitely recommend getting the COVID-19 vaccine to protect you, your pregnancy, and your infant.

If I’m already pregnant should I get the vaccine?

Safety data from around the world shows that women taking the vaccine during pregnancy have seen no effect on their pregnancy. The vaccine has shown itself to be safe and effective. As a result, all the major organizations involved with women’s health care—including the Society for Maternal-Fetal Medicine and the Centers for Disease Control and Prevention—are strongly advocating that people who are pregnant get the vaccine.

Which vaccine is best for a pregnant woman?

There’s no data suggesting that any one of the vaccines is better than any of the others for pregnant women. We know that the effectiveness against preventing disease seems a little bit higher in the mRNA vaccines (Pfizer-BioNTech and Moderna), but all the vaccines that have been authorized by the Food and Drug Administration (FDA) are up to 99 percent effective in preventing severe disease and death. Get whatever vaccine is most readily available to you.

What should I do if I have questions about the vaccine and my fertility?

If you have any questions, ask your health care provider. You can also check the online guidelines from organizations like the World Health Organization and the FDA. There is a lot of great information out there to help us fight back against this pandemic.

What Can I Do About My Post-COVID Ear, Nose, and Throat Symptoms?

Loss of taste and smell. Persistent cough. Nagging throat clearing. Hearing loss. These are just some of the symptoms experienced by those who were infected with and have since recovered from COVID-19.  Researchers estimate that nearly 10 percent of all patients who have recovered from COVID-19 suffer from prolonged symptoms. Often called post-COVID-19 syndrome, this condition can cause a range of health problems including fatigue, headache, shortness of breath, confusion, forgetfulness, and cardiac complications.

Every day, Sam Huh, MD, Chair of Otolaryngology-Head and Neck Surgery at Mount Sinai Brooklyn, sees at least two of these patients with long COVID for persistent ear, nose, and throat symptoms.

“There are many of these patients suffering from a variety of symptoms that last approximately three months or longer after infection,” explains Dr. Huh. “They can be quite debilitating and have a significant impact on their quality of life and ability to return to normal.”

While some of Dr. Huh’s patients had severe COVID-19 infection, others were asymptomatic. “Many patients who come to me were never officially diagnosed with the virus but have symptoms of post-COVID syndrome. However, when I run an antibody test, it often comes back positive for a prior infection,” he says.

Fortunately, many of the ear, nose, and throat symptoms experienced by those with long COVID are reversible.

Loss of smell and taste may return organically, or with training

One of the most common post-COVID symptoms is the loss of smell and taste, also known as anosmia and ageusia. Additionally, on their way to recovery, some patients develop an altered sense of smell and taste called parosmia and dysgeusia. For these patients, nothing smells or tastes like what it should. It is not clear why this happens, but it can cause much distress among the sufferers.

“Smell and taste are linked together,” says Dr. Huh. “If you lose smell, taste often goes with it. Most of these patients get better on their own in a month or so, but others may have issues for up to eight months.”

There are two potential culprits for these altered senses. In some patients, post-infection inflammation and swelling in the nasal tissues prevents odor from reaching the olfactory nerve, which is instrumental for the sense of smell. For others, the COVID-19  virus has damaged the area surrounding the nerve, affecting their sense of smell and taste.

To address this problem, it is important to identify anything in the patient’s medical history that is contributing to the problem, such as abnormal nasal anatomy or allergies. When inflammation is the contributing factor, Dr. Huh recommends using saline rinses to irrigate the nasal passageways, topical or oral steroids, and antihistamines. If the problem is damage around the nerve, Dr. Huh advises olfactory smell training. Research shows that patients can retrain the nose by smelling five strong scents—such as cinnamon, citrus, garlic, rose, or lavender—three times a day.

Your post-COVID cough might be post-nasal drip

Many people who have long COVID struggle with a prolonged cough that lasts for months.

Lung damage is one of the more serious causes of this symptom. Patients experiencing shortness of breath or who are becoming winded when walking up the stairs should seek medical attention immediately. Consult a lung specialist if your symptoms are mild and, if they are severe, head to the emergency room.

The majority of post-COVID patients with chronic cough do not have shortness of breath. Instead, they experience an irritating, nagging tickle in their throat from post-nasal drip caused by post-viral inflammation of the nasal passages. This causes them to cough incessantly. For these patients, Dr. Huh usually prescribes saline rinses, topical or oral steroids, and antihistamines.

A dietary change may help with chronic throat clearing

Post-COVID patients often describe that they feel as though something is stuck in their throat. This feeling causes them to repeatedly try to open their airway by coughing and throat clearing.

“These individuals typically had an awful cough during the symptomatic period when they had COVID-19,” explains Dr. Huh. “The constant coughing caused pressure to rise in their stomach, acid to build up, and reflux to occur.”

Known as laryngopharyngeal reflux, this condition occurs when stomach acid and an enzyme called pepsin travel up to the throat. Thankfully, once the reflux is addressed, patients tend to feel better.

Unlike with the more common gastroesophageal reflux disease, antacids typically do not alleviate these symptoms. However, Dr. Huh has had success with low-protein, plant-based diets, which reduce stomach acid. He also advises that patients drink at least eight cups of water a day.

Extreme post-COVID pain is rare, but treatable

An uncommon post-COVID complication is neuralgia, a severe stabbing pain that can develop after being infected with a virus. This debilitating condition is caused by an inflamed or damaged nerve. Dr. Huh has seen a handful of patients with neuralgia in the throat who experience extreme pain or even incontinence when they cough. These patients are typically treated with neuroleptics, a class of medication normally used to treat psychosis, which research has shown to be beneficial in the treatment of nerve pain.

Post-COVID hearing loss is an unusual side effect that is not fully understood

Another unusual ear, nose, and throat complication is post-viral hearing loss. Dr. Huh estimates seeing one of these patients approximately every month. Physicians are not entirely sure what causes this symptom to develop. They suspect the virus triggers an immune response that may be damaging the tiny vessels inside the ear. Since COVID-19 is associated with blood clots, it is also possible that these vessels become clogged. These patients are typically treated with steroids. However, Dr. Huh says the medication is not always effective in restoring hearing loss. But, some patients can recover their hearing spontaneously.

“Most people recover fairly well when we give them these supportive treatments,” says Dr. Huh. “So, if you are suffering, please know there is hope. I encourage anyone with symptoms to make an appointment because there is probably something we can do to make you feel better.”

Dr. Huh and his colleagues evaluate and treat patients who have symptoms related to the ear, nose, and throat at Mount Sinai Brooklyn. For complications that affect vital organs including the lung, heart, or brain, he advises patients to visit the Center for Post-COVID Care at Mount Sinai.

Make an appointment with Dr. Huh at the following locations:

Mount Sinai Brooklyn
125 St. Nicholas Avenue
Brooklyn, NY 11237

718-756-9025
9 am to 5 pm

Mount Sinai Otolaryngology Faculty Practice
3131 Kings Highway
Suite C1
Brooklyn, NY 11234

718-756-9025

9 am to 5 pm (Wednesdays only)

Mount Sinai Doctors Manhasset
1155 Northern Boulevard
Manhasset, NY 11030

516-370-3434
9 am to 1 pm

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