What Should Gastroenterologists and Patients Know About COVID-19?

Physicians need to consider that gastrointestinal (GI) symptoms, such as nausea, vomiting, and diarrhea could be early signs of COVID-19 infection, especially in those GI patients who also present with upper respiratory complaints. Meanwhile, patients with digestive diseases should closely monitor the news and stay in touch with their doctors if they experience new or unusual GI symptoms.

These were among the insights summarized recently by clinical researchers at the Icahn School of Medicine at Mount in New York City. They also provided renewed guidance to physicians for those patients who have inflammatory bowel disease (IBD) and are being treated with immunosuppressive agents. Research suggests, they said, these patients may be considered at high risk for COVID-19, which is caused by the SARS-CoV-2 virus.

“This is a rapidly evolving area with new information emerging on a daily basis,” said Ryan Ungaro, MD, MS, Assistant Professor of Medicine (Gastroenterology). “We strongly urge our patients to closely monitor the news and to stay in touch with their doctors if they experience new or unusual GI symptoms.”

For physicians seeing a patient with predominant GI symptoms, and some respiratory symptoms, “COVID-19 should be part of a differential diagnosis,” he added.

Dr. Ungaro and world-renowned physician-scientist Jean-Frederic Colombel, MD, published an overview of COVID-19 research findings for the gastroenterology community to help them address their patients’ questions and concerns. It was published on March 17, 2020, in Clinical Gastroenterology and Hepatology, a journal of the American Gastroenterological Association. Dr. Colombel is Director of the Susan and Leonard Feinstein Inflammatory Bowel Disease Clinical Center at Mount Sinai, and Professor of Medicine (Gastroenterology). Also contributing were Mount Sinai’s Timothy Sullivan, MD, Assistant Professor of Medicine (Infectious Diseases), and Gopi Patel, MD, Associate Professor of Medicine (Infectious Diseases).

In their overview, the researchers recounted what has been learned to date:

— The SARS-CoV-2 virus shares 79.5 percent of the genetic sequence of SARS, a respiratory illness caused by a coronavirus that appeared in 2002.

— In that outbreak, diarrhea was reported in up to 25 percent of SARS patients.

— The reported frequency of diarrhea among COVID-19 patients has varied from 2 percent to 33 percent, however, it was one of the prominent symptoms reported in the first U.S. COVID-19 case.

— SARS-CoV-2 has been detected in the stool of COVID-19 patients.

— Common laboratory findings described in COVID-19 patients also include liver function test abnormalities.

“While COVID-19 appears to primarily spread through respiratory droplets and secretions,” the authors wrote, “the gastrointestinal tract may be another potential route of infection.” With this possibility, they reinforced the importance that gastroenterologists use personal protective equipment during endoscopy.

They acknowledged that there are no data currently about the impact of immunosuppressive agents. “At the current time, we should not advise IBD patients, or others on immunosuppressive agents, such as those with autoimmune hepatitis, for example, to hold or stop medications,” they wrote, as the risk of disease flare is still a larger concern at this time. They further suggested that physicians advise their patients on immunosuppression to follow the Centers for Disease Control and Prevention (CDC) guidelines for at-risk populations.

They additionally highlighted new evidence on the cell entry receptor ACE2. “Interestingly,” they wrote, “the cell entry receptor ACE2 appears to mediate entry of SARS-CoV-2,” a similar phenomenon observed with SARS, “and has been demonstrated to be highly expressed in small intestinal enterocytes,” the intestinal absorptive cells that line the inner surface of the small and large intestines. ACE2 is important in regulating nutrient absorption, in particular basic amino acids such as tryptophan, and its disruption may lead to diarrhea.

Mount Sinai is actively studying ACE2 expression in intestinal tissue, said Dr. Ungaro, referring to the work of Saurabh Mehandru, MD, Associate Professor of Medicine (Gastroenterology). “We are particularly interested in determining if the ACE2 inhibitor is differentially expressed in patients with inflammatory conditions of the GI tract to better understand this patient population’s susceptibility to SARS-CoV-2.”

Additionally, Mount Sinai, with collaborators from the University of North Carolina, has started a web-based registry for physicians to report any IBD patients who have a confirmed case of COVID-19. The goal is to better understand the impact of immunosuppressive medications and other risk factors to best guide clinical decisions, he said. Regular updates on reported cases are available at https://covidibd.org/.

Dr. Ungaro reports he served as an advisory board member or consultant for Eli Lilly, Janssen, Pfizer, and Takeda and has research grants from AbbVie, Boehringer Ingelheim, and Pfizer.

Mount Sinai to Begin the Transfer of COVID-19 Antibodies into Critically Ill Patients

Image from Florian Krammer lab. The main target on the surface of most coronaviruses is the spike protein or S. This is a model of the virus and a visualization of a crystal structure of the spike of SARS-CoV-2.

The Mount Sinai Health System this week plans to initiate a procedure known as plasmapheresis, where the antibodies from patients who have recovered from COVID-19 will be transferred into critically ill patients with the disease, with the expectation that the antibodies will neutralize it.

The process of using antibody-rich plasma from COVID-19 patients to help others was used successfully in China, according to a state-owned organization, which reported that some patients improved within 24 hours, with reduced inflammation and viral loads, and better oxygen levels in the blood.

Mount Sinai is collaborating with the New York Blood Center and the New York State Department of Health’s Wadsworth Center laboratory in Albany, with guidance from the U.S. Food and Drug Administration, and expects to begin implementing the treatment later this week.

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“We are hoping to identify patients who can provide the antibodies,” says Dennis S. Charney, MD, Anne and Joel Ehrenkranz Dean of the Icahn School of Medicine at Mount Sinai, and President for Academic Affairs, Mount Sinai Health System. “We are at the front lines in fighting this pandemic and making discoveries that will help our patients.”

Late last week, researchers at the Icahn School of Medicine, in collaboration with scientists in Australia and Finland, were among the first to create an antibody test that detects the disease’s antibodies in a person’s blood. Development of the enzyme-linked immunosorbent assay (ELISA) was led by Florian Krammer, PhD, Professor of Microbiology, in collaboration with Viviana A. Simon, MD, PhD, Professor of Microbiology and Medicine (Infectious Diseases). Dr. Krammer, a renowned influenza researcher, recently made this so-called recipe available to other laboratories around the world so they can replicate it during the pandemic. In January, his lab was quickly retooled to begin studying COVID-19.

In addition to its widespread use in plasmapheresis, the antibody test will provide experts with an accurate infection rate so they can track the trajectory of the disease. The test will help identify health care workers who are already immune to the disease, who can work directly with infectious patients, and it can also help scientists understand how the human immune system reacts to the virus.

The new assay uses recombinant or manufactured antigens from the spike protein on the surface of the SARS-CoV-2 virus. That protein helps the virus enter cells, and it is a key target in the immune reaction against the virus, as the body creates antibodies that recognize the protein and seek to destroy the virus. The researchers also isolated the short piece of the spike protein called the receptor-binding domain (RBD), which the virus uses to attach to cells it tries to invade. The scientists then used cell lines to produce large quantities of the altered spike proteins and RBDs.

According to Dr. Krammer and his co-authors, the assay is “sensitive and specific,” and allows for the screening and identification of COVID-19 in human plasma/serum as soon as three days after the onset of symptoms. The antibodies were derived from three patients who had the disease. The study’s control participants—who did not have COVID-19 but had other viruses, including the common cold—ranged in age from 20 to 70.

Dr. Krammer says his preliminary findings also show that humans have no natural immunity to the SARS-CoV-2 virus, which would help explain why it spreads so quickly. But once the antibody sets in humans do become protected. He also says that at this early stage in the research, there is no evidence that people can lose their immunity and become re-infected.

What You Need to Know About Social Distancing and COVID-19

In the midst of the COVID-19 pandemic, people around the world have been asked—and at times directed by government officials—to practice social distancing. This public health term calls for avoidance of mass gatherings and maintaining a distance of six feet from other people. How can these fairly simple steps limit the spread of the virus? Waleed Javaid, MD, Associate Professor of Medicine (Infectious Diseases) at the Icahn School of Medicine at Mount Sinai, explains social distancing and how the practice aids in the fight against COVID-19.

How does social distancing help limit the spread of COVID-19?

If we are standing close together or talking close together in any setting, it’s possible that our respiratory droplets can be transmitted to the person standing or sitting next to us. Since it appears that respiratory droplets are a primary transmission vehicle of COVID-19, that in itself is a risk.

The other phrase we often hear in relation to ‘social distancing’ is ‘flatten the curve.’ What does that mean?

For coronavirus, the curve is going upward. We have doubling of infections every two to four days, which means there is uncontrolled spread in the community. Through effective use of social distancing, we hope to decrease the overall number of people who get the infection, or flatten that upward curve.

To achieve this, it is important that everyone does their part. So, if I am having a party at home, that will not help this situation. Decreasing the number of transmissions will benefit our community and reduce the stress on the health care system.

If you have an essential job and need to use mass transit to get to work, how can you protect yourself?

I have been using mass transit for several days and, right now, it is easy to maintain social distancing because everything is pretty empty. Since policies have been put in place to reduce staff, crowding has been decreased substantially. However, if you have to get into a more crowded bus or subway, make sure to keep your distance, more than two arms distance apart. If you can’t, try turning around to move your face away from crowded situations

Can I take a walk in the park or a bike ride in an uncrowded area?

It’s really great exercise, but as we are all challenged to sacrifice, if it is not vital for our survival, we should stay home and exercise.  We really cannot participate in any activity that increases community risk. We need to think of this from a different angle, not from personal but from the community we live in, which includes the elderly and those who may have a much higher risk of bad outcomes if they get infected.

Are any outdoor activities acceptable while practicing social distancing?

Minimizing all outdoor activities is ideal. Try to do only what is absolutely necessary. This outbreak is like nothing that has been seen before. So, let’s just pause some of our activities. We need to minimize our exposure and think things through. An individual action could have a grave effect on a community.

Health care providers have to come to work because a lot of lives are affected. We have to be in a social situation. We have to do that for everyone’s health. So think, is your activity more important than the community spread of this virus?

What Do Patients with Respiratory Illness Need to Know About COVID-19?

COVID-19 is a concern for everyone. But patients with respiratory illnesses are among those at highest risk of contracting this virus—or developing a bad case of it. Louis R. DePalo, MD, Clinical Director of the Mount Sinai-National Jewish Respiratory Institute, shares information that respiratory patients and their loved ones need to know about COVID-19.

How can patients and caregivers protect themselves?

To protect yourself, you should follow the guidelines recommended by the U.S. Centers for Disease Control and Prevention. This includes thorough handwashing, social distancing, avoiding groups of more than 10 people, and trying not to touch your hands to your face.

If you or a loved one has a chronic lung disease, here are some additional things you can do to keep safe:

  • Screen any visitors or health aides who come into your home. Ask them if they are sick or if they have a fever. Check whether they’ve traveled to one of the COVID-19 hotspots. And ask if they’ve had contact with a COVID-19 patient. If someone answers yes to these questions, you may want to limit their access to your home.
  • Make sure that you have a robust supply of all the medications and durable equipment that you need.

What should I do if I have symptoms of COVID-19?

The symptoms to worry about are cough, fever, chest congestion, and sore throat. If you or a loved one has these symptoms, you should contact your health care provider. This does not mean to go immediately to the hospital. Instead, take an inventory of your symptoms and contact your doctor. Telemedicine can be a good way to start the conversation. Together, you and your doctor can decide if you need to be tested for COVID-19.

If I need to be tested, what should I do?

Once you and your doctor have decided that you should be tested, your doctor can help you determine where to go. This may be a hospital or a doctor’s office. You want to minimize your travel to the testing facility and wear a face mask, if you have one, to expose as few people as possible. And you should let the facility know you are coming.

Should I keep antibiotics and other medications in the house in case I develop COVID-19?

COVID-19 is a viral disease. It does not respond to antibiotics. You do not need to have antibiotics around to treat COVID-19. But if you or a loved one is susceptible to developing infections for other reasons, that may be a different story. If you are in quarantine and worry that you might not be able to get out to obtain a needed antibiotic, you should discuss this with your primary care doctor.

The same thing could be true for someone with asthma. If you worry about getting sick and not having enough steroids, talk with your doctor. However, do not use systemic corticosteroids to treat COVID-19. Your doctor can advise you on the best approach.

What do I do if I have a doctor’s appointment scheduled?

You should not assume you have to go in for a scheduled doctor’s appointment. Contact your health care provider to find out if you should keep your appointment. For instance, if you are going in for a diagnostic test, it may not be available because of strains on health care facilities.  Your doctor will advise you what to do in this case.

If you have a routine medical appointment, there may be other ways to receive your care or consultation. Many health systems are moving toward telemedicine, to help patients and providers maintain social distance. Telemedicine means communicating remotely with your doctor by video conferencing, texting, or other means. For example, Mount Sinai offers a variety of telehealth services at Mount Sinai Now®.

If you need a critical therapeutic medical visit, it may be a different issue. You and your doctor should talk to weigh the pros and cons of a visit. If, for instance, you would be going in for a biological infusion, you want to weigh the risk of coming into contact with people against the risk of missing a medication that is considered therapeutic. Your doctor can advise you best.

How Front-Line Health Care Providers Can Keep Their Families Safe

As COVID-19 continues to have a dramatic impact around the globe, and front-line doctors, nurses, and health care staff are managing a growing number of cases, there is understandable anxiety.

Waleed Javaid, MD, Associate Professor of Medicine (Infectious Diseases) at the Icahn School of Medicine at Mount Sinai, and Director of Infection Prevention and Control at Mount Sinai Downtown, offers a perspective on how health care providers can help keep their families safe.

“Health care workers, like everyone in the community, should remember hand hygiene, be mindful of social distancing on the home front by avoiding large family gatherings, and in times of a pandemic, they need to have a plan for their families,” Dr. Javaid says.

In this Q&A, he provides additional advice to reassure health care providers how they can help keep their families safe.

What kind of issues do I need to discuss with my family?

Health care workers, like everyone in the community, should discuss all aspects of the pandemic with their families. Everyone should have a plan in place for their home should anyone in the family get ill—and most importantly, planning does not mean panic. It’s a simple thing: should somebody become ill, have you identified a place in the home, an extra bedroom, or separated area, for example, where they can remain separated? The vast majority of people who become ill can get better on their own, and with proper social distancing and precautions, family members can remain protected.

What kind of precautions do I need to take as I leave my shift?

Outside of the hospital environment—where you do not have protective equipment—it is important to reinforce that you should use the same precautions as everyone else: hand hygiene and maintain social distancing.,

First, wash your hands before you leave. Then, take a moment to gather your thoughts. Make sure that if you had any exposure, or any concerns of exposure, that you address it with your supervisor so the issue can be followed up immediately. Check your symptoms—How are you feeling? Also, take an additional moment—because in this crisis you have played a very important role. Wipe your work surface with hospital wipe, and remember to clean the surfaces again when you return.

Should I remove my work clothes before I walk into my house?

Before the COVID-19 pandemic, there was the general recommendation from infection prevention that health care workers in procedural areas like the operating room should change into street clothes before leaving the hospital. The recommendation is still true today. Health care workers who are involved in procedures that may lead to contamination of their scrubs with blood and body fluids should change into street clothes before leaving the hospital. For everyone else who does not work in procedural areas, donning and doffing PPE throughout the day may cause you to sweat more. Respiratory viruses, including coronaviruses, are not transmitted through articles of clothing. But it is not unreasonable to change when you get home if that would make you more comfortable.

Should I avoid my family members when I am at home?

If you are feeling well, there is no reason to avoid your family members. Frequent hand hygiene with soap and water or alcohol-based hand sanitizer is recommended. Everyone should make sure that they cover their nose and mouth when they cough or sneeze, but otherwise you may act normally with your family members.

Should I avoid interacting with my pets?

If you are feeling well, there is no reason to avoid your pets. Similar to contact with humans, you need to make sure that you cover your nose and mouth when you cough or sneeze.

Are there any additional precautions I can take at home—for example, wash my clothes separately?

There is no recommendation about separate clothing screening. But, washed clothes should be dried in a dryer because that helps reduce any contamination on the clothing. You should think about wiping the phone and other products with a compatible cleaner, preferably one that has antimicrobial rating. Wash your hands afterwards, and you should be good.

COVID-19: What Transplant Patients Need to Know

As the outbreak of COVID-19 widens, transplant patients have some special concerns. Meenakshi M. Rana, MD, the Director of Transplant Infectious Disease, Mount Sinai Health System, shares her perspectives on what transplant patients need to know about the virus.

Should transplant patients be concerned about COVID-19?

We’re just learning how this virus could potentially affect transplant patients. We do know that this virus is similar to other common respiratory viruses, and that the symptoms have a lot in common with the flu. Many of the patients affected by COVID-19 have mild symptoms, typically fever and cough. Many of them are fine at home, though some patients may have more severe complications such as pneumonia and may require hospitalization.

What is the special concern for these patients?

We are very concerned about our transplant patients because they have compromised immune systems, and they’re more at risk of having severe complications. It’s really important that our transplant patients take precautionary measures such as hand hygiene. We know the virus is spread by direct contact. However, it is easily killed simply by washing your hands with soap and water for 20 seconds, or using an alcohol-based hand sanitizer. So washing your hands is the most effective thing you can do to prevent transmission of this virus.

What other precautions should transplant patients take?

First of all, if you’re sick, please stay home. If you need to cough, don’t cough into your hands, cough into your elbow. Throughout your home, use a disinfectant to wipe off surfaces that are commonly used such as door handles, bathroom fixtures, and countertops.

As a practical precaution, make sure that you have an adequate supply of your medications at home. Call your physician and ask for a three-month supply of your transplant medications so you don’t run out.

And if you do go out, be very conscientious about hand hygiene and disinfecting surface like your phone. If you know someone is sick, this is not the time to visit with them. And in general, avoid large crowds.

What about masks?

We have been getting a lot of questions about whether protective masks are effective. We don’t think wearing a mask in public is an effective way of protecting yourself. Washing your hands and disinfecting surfaces is a much better way to prevent transmission of this virus.

What should transplant patients do if they have symptoms of COVID-19?

If you have symptoms such as fever, coughing, or shortness of breath, call your transplant provider. We want to know if our patients aren’t feeling well. We will ask about your symptoms. If you’re having mild symptoms, such as a cough, sore throat, or runny nose, we may advise you just to stay at home. We’ll follow up in a day or so to see how you’re doing. If your condition has worsened, and you have a high fever and shortness of breath, we may bring you into the hospital and evaluate you further. If you do decide to come in, we ask that you call ahead so that we know how to triage you, and so that we can determine the best location to receive you.

Meenakshi M. Rana, MD, is the Director of Transplant Infectious Disease for the Mount Sinai Health System. She is also Associate Professor of Medicine of Infectious Diseases at the Icahn School of Medicine at Mount Sinai.

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