New Curriculum for the Master of Science in Biomedical Science Program Provides More Options for Students

Jose Silva, PhD, left, Program Director, Master of Science in Biomedical Science, and Professor, Pathology, Molecular and Cell Based Medicine, and Oncological Sciences, shown in his lab.

The Graduate School of Biomedical Sciences, part of the Icahn School of Medicine at Mount Sinai, has announced a new curriculum structure for its Master of Science in Biomedical Science (MSBS) program.

The MSBS program, started in 2005, features the multidisciplinary research education available at the school, a commitment to translating fundamental biomedical research into disease prevention and novel therapies, and a dedication to preparing students to contribute to the biomedical enterprise in the non-profit or for-profit sectors.

The program prepares students for a range of health-related advanced degree programs and careers, whether focused on medicine, such as the MD program; research, such as the PhD and MD-PhD programs; or manager-level employment in the clinical and industrial sectors. Eligible students should have a degree in science or a related discipline from an accredited college or university.

“For 20 years, our MSBS program has successfully prepared our students for future success in advance degree programs. Nonetheless, we recognized that a changing job environment required us to provide students with more options, and the new program structure does just that,” says Eric Sobie, PhD, Senior Associate Dean for Master’s in Basic Science Programs.

The program has been restructured to address the changing educational landscape. The new MSBS program offers four distinct tracks that target different types of students and provide greater flexibility for how students can complete the program. The total minimum credits has been reduced from 45 to 36 credits over two to four semesters.

Students will choose their track based on their career goals and stage of life:

  • Track 1: Post-Baccalaureate Pre-doctoral (pre-PhD or pre-MD-PhD): This full-time, four-semester track requires students to complete a master’s thesis based on original laboratory research and features a staggered block schedule to facilitate focused study. Students will learn the fundamentals of biomedical sciences while engaging in hands-on research in the laboratories of their chosen Principal Investigators.
  • Track 2: Post-Baccalaureate Pre-medical (pre-MD): This full-time, three-semester track also follows a block schedule structure. Students graduate with a capstone project and a final comprehensive examination. This track allows students interested in applying to MD programs to better prepare for the MCAT exam by offering a lighter course load during the spring semester. Students also benefit from non-curricular experiences available at The Mount Sinai Hospital, such as clinical shadowing.
  • Track 3: Industry/Clinical/Professional Development: This flexible track, available in three or four semesters, combines a block schedule alongside a capstone project. It caters to individuals working in the clinical, educational, or private sector who aim to enhance their skills and advance their careers into higher-ranked, better-paid positions.
  • Track 4: Accelerated Industry/Clinical/Professional Development: This faster-paced version of Track 3 consists of two full-time semesters with a block schedule, a capstone project and a final comprehensive examination. It is designed for individuals seeking to enhance their skills within a condensed time frame.

“Our new curriculum retains our unique hands-on training while offering more options and flexible tracks to support your career goals. Whether you’re interested in research, healthcare, or industry, and whether you’re a recent graduate or a professional looking to advance, we’re committed to helping you gain the knowledge and experience needed to take your career to the next level,” says Jose Silva, PhD, MSBS Program Director and Professor, Pathology, Molecular and Cell Based Medicine, and Oncological Sciences.

These tracks will continue to leverage the multidisciplinary training areas available at the Icahn School of Medicine at Mount Sinai through the PhD programs in Biomedical Sciences, Neuroscience, and the recent joint PhD program in Health Sciences in Engineering with the Rensselaer Polytechnic Institute. This structure allows students to earn a specific concentration or specialization notation on their transcripts by completing a minimum of six credits in concentration-related elective courses, in addition to the required courses and a thesis or capstone project in concentration-related fields.

Students can choose from nine specialty areas to tailor their studies, including:

  • Cancer Biology
  • Disease Mechanisms and Therapeutics
  • Development, Regeneration, and Stem Cells
  • Immunology
  • Genetics and Genomics
  • Microbiology
  • Neuroscience
  • Artificial Intelligence and Emerging Technologies in Medicine
  • Health Sciences in Engineering

Visit our website or contact us to learn more about this program and find out which track aligns with your schedule and career goals.

Here’s What New Yorkers Need to Know About the Bird Flu

You’ve probably heard about it on the news: The bird flu is causing concern.

While the current public health risk is low, the U.S. Centers for Disease Control and Prevention (CDC) is working with local health experts and watching the situation carefully.

Nicholas R. Sells, MD, FACP, FIDSA

“The key message is that people should not be worried. We believe the risk to the population is low,” says Nicholas R. Sells, MD, FACP, FIDSA, Medical Director of Infection Prevention, Mount Sinai Morningside, and Associate Professor of Medicine (Infectious Diseases) at the Icahn School of Medicine at Mount Sinai.

New York Gov. Kathy Hochul delivered the same message—that there was no public health threat—when she recently ordered the temporary closure of bird poultry markets in New York City to allow for special cleaning and inspections.

Here are five key takeaways to keep you updated on the bird flu, also known as avian influenza.

Why the risk to the public is low: Bird flu, which has circulated for decades, is now widespread in wild birds worldwide and is causing outbreaks in poultry and dairy cows in the United States. There have been several recent human cases among dairy and poultry workers. The risk to the general public is low because the current strain of this virus cannot easily spread from person to person, experts say.

Eggs, chicken, and milk: News about the bird flu has prompted some questions among the general public, and experts like Dr. Sells are emphasizing that it is safe to eat eggs and chicken, and drink pasteurized milk that you buy in the store. That’s because the bird flu is not transmissible by eating properly prepared and cooked poultry and eggs. Proper cooking and pasteurization kills the bird flu virus and other dangerous microbes. Milk and infant formula you buy in the store are also safe for infants and children, according to the American Academy of Pediatrics.

What the experts are doing: The CDC is using its flu surveillance systems to monitor for bird flu activity in people. According to the CDC, flu viruses change over time, so there is a risk the virus could be become more easily spread among people. At Mount Sinai, epidemiologists have been in touch with the CDC and the New York State and New York City health departments and have alerted health care providers through the Health System to be on the lookout for patients who may show signs of infection and to review their protocols for testing if needed. The reported signs and symptoms of bird flu virus infections in humans have ranged from no symptoms or mild to severe and include eye redness, fever, cough, and sore throat.

Here’s what you can do: Avoid contact with sick or dead wild birds, poultry and other animals, including dairy cows. Do not touch or consume raw milk or raw milk products or feed them to pets. Cook poultry, eggs and beef to the appropriate internal temperatures.

What about my pets? Bird flu viruses mainly infect wild migratory water birds and domestic poultry. Some bird flu viruses can spread to other animals. Cats and dogs could potentially eat or be exposed to sick or dead birds infected with bird flu viruses, and they could become infected. If your pet is showing signs of illness of a bird flu infection and has been exposed to infected (sick or dead) wild birds/poultry, you should monitor your health for signs of fever or infection.  According to the CDC, it is unlikely you can get sick with bird flu from your infected pet, but it is possible.

Is it the Flu or Maybe Something Else? Symptoms of Common Respiratory Illnesses Can Also Be Signs of Potential Heart Complications.

Did you know that some of the symptoms of the common respiratory illnesses that typically spread during the winter months mimic the symptoms of cardiovascular disease?

For example, if you are feeling short of breath or having chest pain, you may think it’s the flu. But it may be something else, especially if you have heart disease or are at risk for it.

That’s why the experts at Mount Sinai Fuster Heart Hospital are warning about the risk of heart problems during the time that respiratory illnesses typically surge, which also coincides with American Heart Month in February.

With a recent surge in influenza, COVID-19, norovirus, respiratory syncytial virus (RSV), and other respiratory viruses, it’s critical to pay close attention to your heart and symptoms—especially if you have heart disease or the risk factors for it, according to the experts. The combination of these four viruses has been termed a “quad-demic” as they are circulating at elevated levels this winter, according to the Centers for Disease Control and Prevention.

Symptoms of respiratory illness can mimic those of cardiovascular disease or cardiac events in high-risk groups. Some patients may think that symptoms such as being short of breath, weak, cold, or feverish, or having dizziness or chest pain may be solely a result of these winter viruses, but these symptoms could also be associated with, and masking, dangerous cardiovascular complications such as heart attack, pulmonary embolism, viral myocarditis, pericarditis, or even heart failure.

“We have seen people mistaking virus symptoms for serious heart complications. For example, some patients have shortness of breath, wheezing, coughing, swelling, and palpitations, and assume their symptoms are linked to a cold, when in fact they were actually in heart failure. Other patients who have had persistent chest pain and palpitations after acute viral illness may need to consider that, in fact, this could be myocarditis,” says Johanna Contreras, MD, a cardiologist at Mount Sinai Fuster Heart Hospital.

“Don’t ignore these symptoms thinking they are just a long-lasting viral infection, especially if you’re at high risk of heart disease, as this disease can be treated promptly and avoid long-term complications,” says Dr. Contreras. “Make sure to consult your doctor or call 911 if you have worsening chest pain, dizziness, or shortness of breath—a serious cardiac condition can progress quickly and it’s key to catch complications early, before they become life-threatening.”

The recent surge in viruses can also trigger cardiovascular complications among those with established heart conditions, including fever, dehydration, and increased inflammation, and Mount Sinai cardiologists are seeing a rise in these cases across all age groups.

Patients with underlying cardiovascular disease and the associated risk factors are at increased risk. Inflammation can trigger heart attacks in people with coronary artery disease. It can also exacerbate heart failure symptoms and irregular or rapid heartbeats, leading to hospitalization. Doctors have also seen post-viral myocarditis—inflammation around the heart that can progress to complications such as heart failure and cardiogenic shock—in otherwise healthy patients.

“In fact, anyone is susceptible, even health care providers themselves are susceptible, and anyone who is not paying attention to their symptoms may get sick with potentially life threatening complications,” says Icilma Fergus, MD, Director of Cardiovascular Disparities for the Mount Sinai Health System. “A recent patient had severe shortness of breath, weakness, palpitations and fatigue, fearing they had heart failure. After they had bloodwork taken, there was a frantic moment when we could not reach the patient to share results that revealed a significantly elevated troponin level which can be linked to a heart attack. Although we suspected the worst, we eventually reached the patient and they were hospitalized with Influenza A and severe viral myocarditis. They were treated appropriately and luckily there was a good outcome.”

“If you get sick and have chest pain or are out of breath, or have swelling of the legs, and it’s getting worse—especially if you have an underlying heart condition or risk factors such as obesity, diabetes, or a family history of heart disease—your symptoms of a viral infection may in fact represent cardiac symptoms,” says Anuradha Lala, MD, a cardiologist at Mount Sinai Fuster Heart Hospital. “While the immune system’s primary job is to eliminate the virus, the inflammatory response can inadvertently harm cardiac tissue. Thus, if you have a known heart condition, viral infections can bring on exacerbations—or a worsening of the underlying issue—whether it is atrial fibrillation, coronary heart disease, or heart failure.”

Heart Disease Statistics

Heart disease is the leading cause of death among men and women in the United States. Nearly half of adults—more than 121 million people—have some type of cardiovascular disease. According to the Centers for Disease Control and Prevention, more than 700,000 people die of heart disease annually, and 80 percent of these cases are preventable.

High-Risk Groups

Anyone can get heart disease, but people are more susceptible if they have cardiovascular risk factors such as high cholesterol, high blood pressure, diabetes, being overweight, or using tobacco. Age is also a factor, specifically for menopausal women (between 45 and 55) and men older than 55, and men with a family history also are at higher risk. Getting less than six hours of sleep a night may also contribute to poor outcomes.

Certain groups, including African American and Hispanic/Latino people as well as new immigrants, may also be at higher risk of complications from untreated viral illnesses. However, risk for cardiovascular disease in any population can be decreased by taking simple steps toward a healthier lifestyle.

Tips for Lowering Risk of Heart Disease

  • Know your family history
  • Be aware of five key numbers cited by the American Heart Association: blood pressure, total cholesterol, HDL (or “good”) cholesterol, body mass index, and fasting glucose levels
  • Maintain a healthy diet, eating nutrient-rich food and eliminating sweets
  • Limit alcohol consumption to no more than one drink per day for women and men
  • Quit using tobacco or other inhaled substances, including both smoking and electronic cigarettes/vapes
  • Watch your weight and exercise regularly
  • Learn the warning signs of heart attack and stroke, including chest discomfort; shortness of breath; pain in the arms, back, neck, or jaw; breaking out in a cold sweat; and lightheadedness
  • Find practical ways to eliminate stress and focus on mental health

Research Suggests Link Between COVID-19 Vaccine Hesitancy and Increasing Uncertainty in Routine Vaccines for Young Children

Eric G. Zhou, PhD

Young children of parents who declined the COVID-19 vaccine were about 25 percent less likely to receive vaccination against measles, mumps, and rubella (MMR), according to the results of a new study. Historic political and socioeconomic disparities remain important predictors of MMR vaccine hesitancy, but the pandemic appears to have further increased MMR skepticism, researchers said.

 “Our research highlights the link between parental characteristics and MMR vaccine uptake, showing how pandemic-related hesitancy may affect other routine vaccines,” said Eric G. Zhou, PhD, Instructor, Pediatrics, Cardiology, and Population Health Science and Policy at the Icahn School of Medicine at Mount Sinai, a lead author of the study. “Addressing these disparities, through equitable access and fostering trust and transparency in vaccine safety, is key to protecting children from preventable diseases like measles.”

The researchers conducted a cross-sectional study from July 2023 to April 2024 using a digital health survey to examine national population characteristics.

They analyzed responses from more than 19,000 parents of children younger than 5 years old to examine the association between self-reported parental characteristics (i.e., sociodemographics, politics, COVID-19 vaccination status) and children’s MMR vaccination rates, using logistic regression. The study was published January 16 in the American Journal of Public Health.

Children of parents who received at least one dose of the COVID-19 vaccine had higher MMR vaccination rates (80.8 percent) than did children of unvaccinated parents (60.9 percent). The researchers found higher MMR vaccination rates in the Northeast and Midwest regions of the United States.

 “In the United States, we are experiencing a concerning resurgence of childhood vaccine-preventable diseases,” said Ben Rader, PhD, of Boston Children’s Hospital, the study’s corresponding author. “Our research suggests that COVID-19 vaccine hesitancy has fueled increasing MMR vaccine hesitancy, leaving children more vulnerable to highly contagious and life-threatening illnesses like measles.”

My Story: A Mother Expresses Gratitude as Her Son Thrives Following a Heart Procedure as a Newborn

When their son Salvatore was born in 2023 at a hospital in northern New Jersey, Kaitlyn Romano, his mother, and her husband both felt an overwhelming surge of joy and love, emotions they had been anticipating for months. Holding his tiny body, they marveled at how perfect he was. But the pediatrician had heard a heart murmur and ordered an echocardiogram, which would eventually send them to The Mount Sinai Hospital for a lifesaving procedure.

In this first-person account, Salvatore’s mother describes the emotional ups and downs the family experienced, eventually putting their faith in the team at Mount Sinai, which supported the family as Salvatore underwent the procedure. Salvatore is now thriving and living the normal life of a toddler.

When the doctor said they would need to do the test, that wonderful feeling of euphoria slipped away, and our worst fears set in. Mount Sinai pediatric cardiologist Marjorie Gayanilo, MD, interpreted the echocardiogram. Sadly, our beautiful boy’s pulmonary valve was 80 percent blocked. It was clear that he had pulmonary stenosis, which is a thickened heart valve that does not open all the way, making it difficult for blood to flow to the lungs. He needed care immediately.

We’re so thankful for the close children’s health collaboration between Valley Health System and Mount Sinai. Our care team at Valley Health System referred us to The Mount Sinai Hospital, where he underwent a minimally invasive procedure called a balloon valvuloplasty that opens and widens the blocked valve. The procedure was performed by Barry Love, MD, Director of the Congenital Cardiac Catheterization program at the Mount Sinai Children’s Heart Center.

As a mother, I had immense fears as my baby boy was sent off from my arms and transferred. Each time I heard the lullaby music that went off throughout Valley Health System’s speaker system to let people know another baby was born, I cried. I longed to hold my boy in my arms and bring him safely home. My husband and I had varied emotions, and we often had to put on a brave face. We longed to protect our son, but there was nothing we could do but have faith and trust the doctors. We were both assured that Dr. Love, as well as the entire medical team at Mount Sinai, were the very best. Thankfully, we can both attest to this being absolutely true and nothing less.

Following the procedure, Salvatore continued his care at the Neonatal Intensive Care Unit at Mount Sinai Kravis Children’s Hospital for three weeks. He made strides and progressed each day in recovery. Each day felt like an emotional roller coaster, and our lives had suddenly been flipped upside down. But the Mount Sinai team was very communicative and thorough. They shared updates each day on our son’s progress, his condition, and the effect that the procedure had on his heart, and whether it was effective enough and what would be the next steps to take.

The hospital staff became our lifeline, from the nurses, to the social workers, and doctors who explained any type of procedure, test, or treatment that was administered. We will never forget the doctors who took the time to explain what his condition was, who drew a heart on a piece of paper to describe to us clearly what was wrong, and the nurses who took care of our son and went above and beyond. Each time we called the unit, the nurses reassured us that they would tell Salvatore how much we loved him and this helped put our minds at ease.

Our strong baby boy recovered fully and finally, after three weeks, Salvatore was able to come home with us without any complications or further treatments needed, thanks to the exceptional care and support of the staff at Mount Sinai.

Each month since he returned home, Salvatore has been evaluated and cared for by Dr. Gayanilo. Dr. Gayanilo is nothing short of amazing. She is patient, kind, reassuring, and vigilant. She always took her time to explain in detail updates about Salvatore’s condition. She always made us feel at ease. Thanks to Dr. Gayanilo and the incredible skill and close collaboration between the doctors at The Mount Sinai Hospital and Valley Health System, we feel Salvatore’s recovery was even more remarkable.

Salvatore is now playing and living his life like any normal one-year-old.

We are filled with immense gratitude for every staff member who was involved in our son’s day-to-day care. We would especially like to thank Salvatore’s social worker who went above and beyond to ensure that we were provided with resources and support. Thanks to the pediatrician who saw our son when he was born, to Dr. Gayanilo, Dr. Love, and the entire team at Mount Sinai. Thanks to you, our son is alive and thriving. His heart may have been born imperfect, but in every other way, he is perfect to us.

If your child has a heart condition, schedule an appointment or refer a patient to Dr. Gayanilo at Mount Sinai Kravis Children’s Hospital. Call 844-733-7692 or visit our website.

Clinical Research Unit Is a “Hidden Gem” Supporting Mount Sinai Investigators and Patients

From left: Betty Chen, FNP; Rachelle Mallare, RN; Margaret Garrett, FNP; Christian Malatesta, FNP; Berenissis Valenzuela, MA; Karmiely Morillo, Patient Coordinator

The Clinical Research Unit (CRU) is a valued resource hub for researchers at Mount Sinai—providing everything from exam rooms, to research space and specimen storage, to compassionate nursing support, and help with administrative and procedural tasks.

Manisha Balwani, MD, MS, Chief of the Division of Genetics and Genomics, is appreciative of the skill and compassion of the team. “The CRU team have truly been excellent partners in getting rare disease treatments to patients. They have the skills to navigate administering complex therapies while creating a safe environment for patients who are vulnerable and anxious.”

The center was established in 1963 as part of a nationwide effort by the National Institutes of Health to provide dedicated space and resources for conducting medical research across medical disciplines within academic medical centers. Located in the Annenberg Building at The Mount Sinai Hospital, the CRU is a comprehensive resource hub for investigators and the Mount Sinai community who wish to undertake clinical research. Currently there are 122 active ongoing studies across multiple disciplines.

Christian Malatesta, FNP, on staff at the CRU, and at Mount Sinai for 30 years, calls the unit a “hidden gem” that is especially valuable for investigators who do not have the time or resources to implement the clinical procedures required for clinical trials.  Along with Betty Chen, FNP, and Unit Nursing Director, Margaret Garrett, FNP, the team of nurse practitioners, one registered nurse, and one medical technician, are able to assist with study-related medical evaluations of research participants, including:

  • Performing physical examinations
  • Administering study medications
  • Adverse event monitoring including telemetry monitoring
  • Obtaining electrocardiograms

The team also assists with reviewing signed consent forms and the required study-related schedules of events to ensure that all elements are in place to safely and effectively proceed with clinical procedures.

Investigators across the system value their partnership with the CRU.

Alexander Kolevson, MD, a principal investigator on studies in autism spectrum disorder as part of the Seaver Autism Center for Research and Treatment, says, “We believe our work has made major contributions to the field of autism and neurodevelopmental disorders and I’m not exaggerating when I say that we could not have done it without the outstanding CRU team. They are highly skilled and consistently flexible and accommodating. Importantly, our most severely disabled and behaviorally challenging patients are treated effectively with kindness and empathy.”

Stephen Krieger, MD, FAAN, a neurologist at The Corinne Goldsmith Dickinson Center for Multiple Sclerosis, also praises the CRU. “We are currently the only recruiting site in New York City for a trial of a new infused monoclonal antibody for progressive multiple sclerosis (frexalimab), and my team has worked hand-in-hand with the CRU from our initial site assessment and activation through to the enrollment and infusion of our patients. I am very grateful to the CRU team for their professionalism and the warm and compassionate way they have worked with our patients, many of whom have significant disability from their neurological disease.”

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