National Cancer Institute Leader Visits Mount Sinai

From left: Luis M. Isola, MD, Professor of Medicine (Hematology and Medical Oncology), and Pediatrics; Ramon Parsons, MD, PhD, Director, The Tisch Cancer Institute; Norman E. Sharpless, MD, Director, National Cancer Institute; and William Oh, MD, Deputy Director, The Tisch Cancer Institute, and Associate Director of Clinical & Translational Research for the Institute.

Aging is one of the greatest risk factors for developing cancer, which is most frequently diagnosed among people aged 65-74. But there are no simple explanations for the “multifaceted” science behind this connection, according to Norman E. Sharpless, MD, Director of the National Cancer Institute (NCI).

On Thursday, September 13, Dr. Sharpless addressed the topic in a seminar titled “The Dynamic Interplay between Cancer and Aging,” which he presented before a standing-room-only crowd in Davis Auditorium on The Mount Sinai Hospital campus. Dr. Sharpless has devoted much of his career to studying the connection between cancer and aging. Developing a better understanding of this relationship is particularly important, he said, because people over the age of 65 make up the fastest growing segment of the nation’s population.

Dr. Sharpless was invited to speak about his own research by The Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai, where he spent the earlier part of the day meeting with leaders of the Institute and medical school. He had lunch with postdoctoral fellows and students who work in Mount Sinai’s cancer-focused laboratories, and met with faculty and staff who oversee Mount Sinai’s Cancer Center Support Grant. The grant provides Mount Sinai with its NCI designation as one of an elite group of U.S. institutions committed to the research and treatment of cancer.

During the day’s meetings, Dr. Sharpless shared his vision for NCI programs and discussed trends in funding and cancer research. The Tisch Cancer Institute received its NCI designation for the fi rst time in 2015 and is preparing to renew the competitive grant in 2019. Since his appointment to the NCI in 2017, Dr. Sharpless has spent time visiting NCI-designated cancer centers around the country. On his recent trip to New York City, he also visited the Albert Einstein Cancer Center.

A Campaign to “Scrub Out Cancer”

Benjamin Salter, DO, right, and Lucy Duffy, RN, second from right, with some of the organizing team members of the “Scrub Out Cancer” campaign.

Perioperative staff throughout The Mount Sinai Hospital can be seen dressed in pink—from head to toe—in the Operating Room (OR) during October as part of a new effort known as “Scrub Out Cancer.”

“We are wearing pink OR warm-up jackets, bouffant caps, surgical masks, exam gloves—and even socks,” says Benjamin Salter, DO, Assistant Professor of Anesthesiology, Icahn School of Medicine at Mount Sinai, who created the campaign with Lucy Duffy, RN, Vice President of Perioperative Services.

“Our fundamental goal is to raise awareness and speak to our staff and those in other departments about the benefits of cancer screening and living a healthy lifestyle.” The “Scrub Out Cancer” team is also distributing cancer-screening information and giveaways to their perioperative colleagues.

Observing International Overdose Awareness Day

Anita Kennedy, left, Outreach Coordinator, Opioid Treatment Program at Mount Sinai Beth Israel, with Erin Clyne, an attendee of the remembrance event.

Through poetry, music, and spoken-word performances, participants told stories of drug addiction and loss on International Overdose Awareness Day, Friday, August 31, in Davis Auditorium.

The event, called a remembrance, was open to the public and sponsored by the Respectful & Equitable Access to Comprehensive Healthcare (REACH) program in the Division of General Internal Medicine, Icahn School of Medicine at Mount Sinai, and the Mount Sinai Center for Spirituality and Health.

Attendees lit candles and wrote notes in honor of lost family and friends, and experts provided information on harm reduction, including lessons in administering the overdose-reversal drug naloxone. Members of the Center for Spirituality and Health distributed aromatherapy and herbal teas from the mobile wellness Chi Cart™.

“The lives of those lost to drug overdose are no less worthy than any other lives, and their loss is no less dignified and deserving of remembrance and honor,” said Jeffrey Weiss, PhD, Director of the REACH program. “We can acknowledge the loss of those to drug overdose, free of any stigma, shame, or concealment.”

“New Heights” of Achievement Marked at Convocation

Dennis S. Charney, MD, delivered the State of the School Address.

A sense of accomplishment pervaded the 2018 Convocation Ceremony, which honored 13 renowned faculty members and celebrated the 50th anniversary of the Icahn School of Medicine at Mount Sinai. The event, held on Thursday, October 4, marked the beginning of the academic year and featured the annual State of the School Address by Dennis S. Charney, MD, Anne and Joel Ehrenkranz Dean, Icahn School of Medicine at Mount Sinai, and President for Academic Affairs, Mount Sinai Health System.

“We are reaching new heights,” Dr. Charney said as he welcomed the honorees, their families and friends, faculty, staff , and Mount Sinai benefactors who filled Goldwurm Auditorium. “We have never had more endowed chairs than we are awarding tonight, which I think speaks for the health of our medical school and our Health System.” The honorees received named professorships in fields including computational biology, genetics and genomic sciences, personalized medicine, palliative care, geriatrics, therapeutics discovery, ophthalmology, and neuroscience.

Among its many accomplishments, Dr. Charney said, the Icahn School of Medicine at Mount Sinai received $348.5 million in National Institutes of Health (NIH) funding in fiscal year 2018—a 9.4 percent increase over the prior year—ranking the school No. 12 in the nation. “We also rank No. 4 in research dollars per investigator, which means our individual faculty are among the best in the country,” Dr. Charney said, citing figures from the Association of American Medical Colleges.

The School of Medicine has the largest Graduate Medical Education program in the nation, with more than 2,500 residents and fellows. Its master’s and PhD programs are growing in size and quality, and Mount Sinai is launching a biomedical data science program, “which is consistent with our overall commitment to be one of the best places in the country, if not the world, in genomic and data science,” Dr. Charney said. The matriculating class of medical students has a median grade point average of 3.84 (out of 4.0), and the Flex Med admissions program helped make it a well-rounded group. “We are always looking to recruit students who represent the spectrum of talents in America,” he said, “whether they major in humanities or hard science or have experience in the military.”

Among other high points:

Mount Sinai Innovation Partners, which translates research findings into health care products and services, generated 211 patents, 144 inventions, and 53 new licenses and options for the use of research. In addition, the new i3 Asset Accelerator funded four start-up projects based on Mount Sinai research, with seven proposals now under review.

The Mount Sinai Doctors Faculty Practice—the largest in the nation—had 7.8 percent higher revenues compared with 2017, and the number of calls to its Access Center rose to 3.48 million in 2018 from 2.67 million in 2017.

Mount Sinai, for the second consecutive year, was ranked No. 1 by DiversityInc magazine among hospitals and health care systems in the nation for excellence in diversity management and best practices. In addition, the Patricia S. Levinson Center for Multicultural and Community Affairs marked its 20th anniversary.

The Office of Well-Being and Resilience, led by Jonathan A. Ripp, MD, MPH, Senior Associate Dean, was created to support the well-being of students, staff, and faculty.

Mount Sinai launched an online series of articles in partnership with Scientific American Custom Media that marks the 50th anniversary of the Icahn School of Medicine and takes a sweeping look at research and innovation fueling the next generation of treatments.

Looking ahead, Dr. Charney said, “Our guiding principles are to take advantage of the size and excellence of our Health System, to have unrivaled excellence in our medical and graduate education, and to anticipate new areas of research. We developed a strategic plan in 2017, and we are now implementing that plan in 2018.” The latest initiatives include renovation at 3 East 101st Street that will create a 45,000-square-foot facility for data science and technology. In a comprehensive capital campaign, the Mount Sinai Health System is seeking to raise $1.5 billion or more to fund projects, including a Life Science Center at 102nd Street and Madison Avenue.

Among its research priorities, the School of Medicine is advancing immunology by exploring therapies that target cancer, heart disease, diabetes, and brain disorders. It also is making a major investment in precision medicine. “This is a big initiative of the NIH,” Dr. Charney said, “and Mount Sinai will lead the way” with the advantages of a large and diverse patient population and expertise in genomics, big data, supercomputing, and bioinformatics.

Marta Filizola, PhD, left, the Sharon and Frederick Klingenstein/ Nathan Kase, MD Professor, and Dean of the Graduate School of Biomedical Sciences, with Terry A. Krulwich, PhD, a pioneering predecessor in both roles.

Dr. Charney took a moment to recognize a “legendary leader,” Terry A. Krulwich, PhD, Professor Emeritus of Pharmacological Sciences, and Dean of the Graduate School of Biomedical Sciences from 1981 to 2002—one of the first women in the nation to fill this role. Dr. Krulwich, who recently retired, was a mentor and role model, and a groundbreaking bacteriologist who was continuously funded by the NIH for 40 years. Dr. Charney thanked her for decades of service to Mount Sinai, and she was acknowledged with lasting applause.

“I think we can be very proud of what the School of Medicine has become in just 50 years,” said Peter W. May, Chairman, Boards of Trustees, Mount Sinai Health System. “It is one of the nation’s top medical schools, in which we are training bright, creative, and innovative doctors. But we are also engaged in great medical research that generates new insights, diagnostics, and treatments.”

Kenneth L. Davis, MD, President and Chief Executive Officer, Mount Sinai Health System, noted these achievements and also urged the honorees to keep in sight the school’s core values, such as putting patients first, serving everyone who needs care regardless of their ability to pay, collaborating in the lab, and making discoveries that improve the lives of patients. “Fifty years ago, when I came to Mount Sinai as a medical student, I came to be a physician-scientist,” Dr. Davis said. “But the longer I have been here, the more I realized that my job was not just writing papers. It was not just getting millions of dollars in grants. It was about what would be left behind, what was lasting. My job was to be a steward of this institution—of its legacy and its heritage. That was my responsibility, and now it is yours.”

The Convocation Honorees

Front row, from left: Amy S. Kelley, MD, MSHS; Jian Jin, PhD; Ethylin Wang Jabs, MD; Marta Filizola, PhD; Kenneth S. Boockvar, MD, MS; Schahram Akbarian, MD, PhD; and Dennis S. Charney, MD. Back row, from left: Paul A. Slesinger, PhD; Eric Schadt, PhD; Rachel Saunders-Pullman, MD, MPH, MS; Richard B. Rosen, MD; Adam A. Margolin, PhD; Ruth Loos, PhD; Andrew B. Leibowitz, MD; and Peter W. May.

Schahram Akbarian, MD, PhD, Mount Sinai Professor in Psychiatric Epigenomics

Kenneth S. Boockvar, MD, MS, Anna A. Greenwall Professor of Geriatrics and Adult Development

Marta Filizola, PhDSharon and Frederick Klingenstein/Nathan Kase, MD Professorship

Ethylin Wang Jabs, MDMount Sinai Professor in Developmental Genetics

Jian Jin, PhDMount Sinai Professor in Therapeutics Discovery

Amy S. Kelley, MD, MSHSHermann Merkin Professor in Palliative Care

Andrew B. Leibowitz, MDMount Sinai Professor in Perioperative Care

Ruth Loos, PhDCharles Bronfman Professor in Personalized Medicine

Adam A. Margolin, PhDJean C. and James W. Crystal Professor of Genetics and Genomic Sciences

Richard B. Rosen, MDBelinda Bingham Pierce and Gerald G. Pierce, MD Distinguished Chair of Ophthalmology

Rachel Saunders-Pullman, MD, MPH, MSBachmann-Strauss Professor

Eric Schadt, PhDMount Sinai Professor in Predictive Health and Computational Biology

Paul A. Slesinger, PhDLillian and Henry M. Stratton Professor of Neuroscience

Advancing Research for Alzheimer’s Disease

Ana C. Pereira, MD, with Christopher Smith, Executive Director, Alzheimer’s Association, New York City Chapter, left, and Keith Fargo, PhD, Director of Scientific Programs and Outreach, Alzheimer’s Association.

Two physician-scientists at the Icahn School of Medicine at Mount Sinai have each received a 2019 Alzheimer’s Association Research Grant of approximately $150,000 over the next three years for their respective research projects.

Ana C. Pereira, MD, Assistant Professor of Neurology, and Neuroscience, is studying the molecular profiling of glutamate and tau-mediated toxicity in Alzheimer’s disease. Andrew Varga, MD, PhD, is Assistant Professor of Medicine (Pulmonary, Critical Care and Sleep Medicine). He is investigating the effect of chronic sleep disruption on brain tau phosphorylation spread.

The Alzheimer’s Association Research Grant program, which funds early-career researchers who have received their doctoral degrees or completed their residency within the past 10 years, aims to nurture a robust pipeline of fresh ideas while laying the groundwork for future grant applications.

A Birthday Party for Amos and Professor Bunsen Honeydew

Two beloved members of Mount Sinai Kravis Children’s Hospital—sweet-natured golden doodles Amos and Professor Bunsen Honeydew—were treated to a Hawaiian-themed birthday party in August.

Patients, families, and staff gathered at the hospital to show their love and support for the dogs, while enjoying crafts activities, eating cupcakes, and signing a celebratory banner in honor of Amos’ and Professor’s third birthdays. The dogs are related, but were not part of the same litter. The excitement of the party appeared to tire out the four-legged guests of honor—they both fell asleep one hour into the festivities, with Hawaiian music playing in the background.

Under the direction of skilled clinical handlers in the Child Life and Creative Arts Therapy Department, Professor works with patients in the Blau Center for Children’s Cancer and Blood Disease and the Alice Gottesman Bayer Pediatric Intensive Care Unit. Amos comforts pediatric inpatients and is a popular attendee at Kravis’ coffee hour, a weekly offering for the parents and families of patients.

The dogs are full-time employees of Mount Sinai Kravis Children’s Hospital through the Paws & Play facility dog program. The program—supported by PetSmart Charities® and the Mount Sinai Auxiliary Board—is the first of its kind in New York State.