Sooyun Caroline Tavolacci, MD, MSCR, with her mentor, Anelechi Anyanwu, MD
Sooyun Caroline Tavolacci, MD, MSCR, is a third-year PhD student in the Clinical Research Program at the Icahn School of Medicine at Mount Sinai and a surgeon-scientist in training. Her dissertation research focuses on heart transplantation outcomes, specifically evaluating beating heart transplantation using ex-vivo heart perfusion and its impact on donor pool expansion, under the mentorship of Anelechi Anyanwu, MD, Professor and Vice Chair, Department of Cardiovascular Surgery, and Natalia Egorova, PhD, Professor, Department of Population Health and Science.
In parallel with her doctoral training, Dr. Tavolacci works as a clinical research coordinator in the Department of Cardiovascular Surgery at The Mount Sinai Hospital, Clinical Research Office, which is led by Julie Swain, MD, Professor and Vice Chair of the Department.
Having progressed from an international master’s student to a PhD candidate and hospital employee, she reflects on five years of training marked by perseverance, balance, and growth across research, work, and life.
Her interest in medicine began early, sparked by seeing the Jarvik-7 artificial heart in a school textbook. She was fascinated by the idea of replacing a vital organ, the multidisciplinary care behind it, and the trust required between patients and surgeons.
“What I liked most during my two years of research training at the Icahn School of Medicine was that I could apply what I learned in the classroom right away in real-world settings.” -Sooyun Caroline Tavolacci, MD, MSCR
Cardiothoracic surgery has since become her lifelong passion. She completed six years of medical school in South Korea, followed by a cardiovascular surgery sub-internship in Brescia, Italy. After graduating from medical school, and realizing that she lacked experience in clinical research, she sought a program that bridged scientific research and clinical practice, leading her to Mount Sinai’s Graduate School of Biomedical Sciences.
“The Icahn School of Medicine is unique as a pioneering model for a medical school grown directly from a hospital, not a university” she says. “The rich clinical environment, combined with strong multidisciplinary faculty, makes it ideal for studying clinical research.”
In 2021, in the middle of the COVID-19 pandemic, she entered the Master of Science in Clinical Research (MSCR) program at the Icahn School of Medicine while working on an NIH-funded study examining the serological response to the SARS-CoV-2 vaccine in lung cancer patients led by Fred Hirsch, MD, PhD, Professor and Director, Center of Excellence for Thoracic Oncology, The Tisch Cancer Institute. She described this experience as firsthand exposure to bench-to-bedside translational research. Her days began in the lung cancer clinic at the Institute and ended in the Biorepository and Pathology CoRE laboratories.
“Weekly meetings involved thoracic oncologists, thoracic surgeons, pathologists, virologists, immunologists, biostatisticians, and radiologists. This multidisciplinary collaboration and exposure to different perspectives taught me how to approach team science in research,” she says.
Dr. Tavolacci completed her master’s thesis, in which she investigated the mechanisms underlying sex-based differences in immunotherapy response in lung cancer, with Dr. Hirsch and co-mentor Rajwanth Veluswamy, MD, MSCR, a former faculty member of the Icahn School of Medicine and a graduate of the MSCR program. She presented her work at national and international meetings and published her several peer-reviewed articles during her master’s program.
“What I liked most during my two years of research training at the Icahn School of Medicine was that I could apply what I learned in the classroom right away in real-world settings,” she says. “I was extremely satisfied with the coursework and the quality of education I received.”
After completing her MSCR in June 2023, she decided to continue her research education and was accepted into the PhD in Clinical Research program.
“I developed a strong interest in biostatistics during my master’s program,” she says. “My experience was primarily in thoracic oncology, with a focus on lung cancer; however, I wanted dedicated time to learn outcomes research in cardiovascular surgery.”
After her acceptance into the PhD program, she faced significant financial hardship due to a loss in her family and visa restrictions that limited her ability to secure a job at The Mount Sinai Hospital at that time.
She considered returning to South Korea or continuing her academic journey in the United States, but instead reached out for help. In recognition of her academic excellence, she received Emergency Fund support from the Office of Postdoctoral and Student Affairs at the Graduate School of Biomedical Sciences and continued her work-study program through Westchester Medical Center in New York State. During this time, she completed her PhD coursework and conducted heart failure and transplant outcomes research under the mentorship of Suguru Ohira, MD, PhD, Cardiac Surgeon at Hartford HealthCare. This included large database analyses using the United Network for Organ Sharing registry.
Now Dr. Tavolacci balances her dissertation research with her role as a research coordinator in the Department of Cardiovascular Surgery at Mount Sinai. She credits the Icahn School of Medicine’s hospital-based model for naturally generating research questions through close interaction with surgeons, fellows, and residents.
“The clinical exposure I gain every day as a research coordinator helps me understand why these variables scientifically matter in clinical trials and studies, and it directly shapes my academic research,” she says. “With my master’s and PhD training in clinical research, I have a strong understanding of research methodology, such as study design, logistics, objectives and hypotheses, and analysis planning. This foundation is incredibly helpful in performing my role. It is a humbling experience to care for patients and to advocate for advancements in clinical research.”
Dr. Tavolacci frequently mentors prospective international applicants, particularly those navigating funding challenges in the PhD in Clinical Research program. She receives emails and LinkedIn messages from many people interested in clinical research asking how to find a mentor, identify research topics, and secure funding.
“It is challenging, and sometimes being equivalent as an international student is not enough—you have to be better to get noticed. However, people who have been through similar processes recognize your strengths.” She strives to do the same for prospective applicants by sharing her honest journey as an international student.
Dr. Tavolacci recalls what her PhD mentor, Dr. Anyanwu, said during their first meeting: “See how far you have come.” She carries this message with her whenever she faces difficulties or setbacks, using it as a reminder to keep moving forward.
In 2026, Dr. Tavolacci will present her doctoral research at various national meetings within the cardiothoracic surgery community. Throughout her academic journey, she has learned that research comes with many practical challenges. What has been most helpful to her is maintaining concentration and focus to push projects forward and see them through to completion. What she learned the hard way is that everything takes time and effort, and that there are many failures behind every achievement in academia.
Dr. Tavolacci will complete her PhD in two years and plans to enter cardiothoracic surgery residency. Her training will allow her to practice surgery while designing and conducting clinical studies and trials. Her ultimate goal is to become a surgeon-scientist.