Dennis S. Charney, MD, at Commencement: A Final Address, a Career to Remember
Dennis S. Charney, MD, Anne and Joel Ehrenkranz Dean of the Icahn School of Medicine at Mount Sinai, giving the Commencement address
In the 18 years that Dennis S. Charney, MD, has served as the Anne and Joel Ehrenkranz Dean of the Icahn School of Medicine at Mount Sinai, he has often applauded the achievements of graduating students during Commencement while calling upon them to be resilient during difficult times.
On Thursday, May 8, at the School’s 56th Commencement, the message of resilience resounded, but this time more aptly so—this was Dr. Charney’s last Commencement speech, and he reflected upon how staying the course in the face of challenges rang true throughout his life and career.
“Our school has faced hurdles along the way,” Dr. Charney told the crowd at David Geffen Hall at Lincoln Center. He described the institution having to overcome its financial difficulties in 2003, navigating the Great Recession in 2008, Hurricane Sandy in 2012, and the COVID-19 pandemic in 2020.
“Yes, these are challenges, but we have prevailed in the past. And we shall prevail again,” he said.
In his final address as Dean, Dr. Charney imparted some wisdom to the Class of 2025. Here’s a look at the themes he brought up.
“Success is not final. Failure is not fatal.”
Even as students, the Class of 2025 has made an impact. They have made important scientific discoveries about human disease, been passionate advocates for human rights, and shown potential to be exceptional physicians and scientists, said Dr. Charney.
However, the challenges do not stop once they leave the Icahn School. “You will face situations when you cannot heal a patient, or worse, where you cannot save a patient,” he said. “You will experience disappointment along the way as you try to make scientific breakthroughs. You may even experience skepticism and ridicule.”
Staying resilient in the face of challenges will be key. “What matters is how you meet disappointment and failure—which is far more important than how you embrace success,” said Dr. Charney. “Success is not final. Failure is not fatal. It is the courage to continue that counts,” he said, quoting Winston Churchill.
Keeping the cup full
Core to being resilient is to be kind, and care for oneself, said Dr. Charney.
“You cannot pour from an empty cup,” he noted. “So, I want to remind you to constantly build your resilience skills to keep your cup full.”
Tapping insights from his own research, he shared the following tips: maintain a positive attitude; allow yourself to reappraise highly stressful, even traumatic, events, and put them in proper perspective; nurture your supportive social network; seek role models; take care of your physical well-being; and embrace your personal moral compass.
These mantras have helped him navigate not just professional challenges, but personal ones, said Dr. Charney. These include having lost a grandchild to a rare genetic disorder, surviving an attempted murder, and overcoming cancer.
“Like all of us, life will throw you curveballs,” he said, paraphrasing a quote from Ernest Hemingway. “But I know you will be strong in the broken places.”
Dr. Charney steps down as Dean on Monday, June 30, and was honored for his legacy of leadership at Mount Sinai’s 40th annual Crystal Party, held Tuesday, May 20, at Pier Sixty, Chelsea Piers. To learn more about the event, click here. Also, in recognition of his contributions, he received an honorary Doctor of Science from the Icahn School of Medicine during Commencement.
Here’s a look at Dr. Charney’s career and highlights, from early medical training to leading the Icahn School to where it is today.

Dennis S. Charney, MD (right), received a Doctor of Science from the Icahn School of Medicine at Mount Sinai. He was hooded by Alexander Charney, MD, PhD (second from right), and the honorary degree citation was given by Kenneth L. Davis, MD (second from left). Eric J. Nestler, MD, PhD (left), gave the introductions.
Dr. Charney is also well-known for his scientific research. Did you know that he discovered ketamine could be used as a fast-acting antidepressant?
To read more about Dr. Charney’s research highlights, click here
1977
1978-1981
Psychiatry residency at Yale School of Medicine