Interest in cannabidiol (CBD) has increased dramatically in recent years. Available in oils, lotions, and vaping fluid, the substance has been touted as a cure-all for various ailments including anxiety, arthritis, and insomnia. While its growing reputation is impressive, is CBD just an alternative medicine fad or can it really help?
For the past decade, Yasmin Hurd, PhD, Director of the Addiction Institute of Mount Sinai, has been at the forefront of CBD research. Below, she breaks down the three things you should know before adding the substance to your routine.
What is CBD and what can it treat?
CBD is one of more than 100 substances known as cannabinoids found in the Cannabis plant. There are two main cannabinoids, CBD and THC (tetrahydrocannabinol). CBD does not cause a high, unlike THC, which is the main psychoactive ingredient in cannabis (including marijuana and hashish).
Although you can find many advertisements touting CBD’s medicinal uses, the U.S. Food and Drug Administration (FDA) has not approved CBD to treat any disorders in adults. The only FDA approval for CBD is for the treatment of two rare and severe forms of childhood epilepsy. However, CBD has been investigated for the treatment of anxiety, cannabis and opioid use disorder, Crohn’s disease, diabetes, epilepsy, pain, Huntington’s disease, sleep disorders, Parkinson’s disease, and schizophrenia/psychosis.
If there is no FDA approval, what evidence supports CBD use?
In limited clinical trials, CBD was found to help reduce social anxiety, post-traumatic stress disorder, and craving in those with an opioid addiction. However, most of these clinical studies involved a small number of participants. For a more conclusive verdict, larger, more sophisticated trials are needed.
Fortunately, more extensive research is in the works. In May 2019, my team published study results from a clinical trial showing that CBD reduced craving and anxiety in individuals with a history of heroin abuse. This suggests that it may play a role in helping to break the cycle of addiction. We are now starting larger studies.
Is CBD safe? If I decide to use it, should I tell my doctor?
Yes and yes. A consistent finding in clinical studies is that CBD is safe. However, it is not FDA-approved and researchers are still investigating its use. Because of this, it is critical that your doctor is aware of your CBD use. Making your doctor aware will help to avoid any potential for CBD to interact with medications you may be taking. Even if you do not take regular medications, you should keep a log of your daily activity, including any changes in your physical state, mood, and sleep following use.
Additionally, because CBD is not regulated by the FDA, you should be careful about the source of your CBD. Many products sold as “pure CBD” contain THC and other ingredients that can be harmful, such as lead, mold, or synthetic cannabinoids, which can cause paranoia, hallucinations, or other psychotic symptoms. For a safer, higher-quality product, look for CBD that has a certificate of analysis—this indicates that the product has been thoroughly checked for contaminants and allows you to view its THC and CBD levels.
Yasmin Hurd, PhD, is the Ward-Coleman Chair of Translational Neuroscience and the Director of the Addiction Institute at Mount Sinai. She is currently the principal investigator on a clinical trial of CBD for treating opioid use disorder, a neuroimaging study of CBD’s effects on the human brain, and a study looking at neurodevelopmental effects of cannabis and its epigenetic regulation.