May 31, 2013 | Research, School
Shutting down inflammation within the body, and then harnessing the immune system to recognize and destroy cancer cells, could provide the one-two punch needed to effectively treat head and neck cancers, according to researchers at Icahn School of Medicine at Mount Sinai.
Research into the pivotal role played by the inflammatory molecule inducible nitric oxide synthase (iNOS) in promoting cancer growth and immune evasion is being led by Andrew G. Sikora, MD, PhD, Assistant Professor and Director of Head and Neck Translational Research in the Department of Otolaryngology, Head and Neck Surgery.
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Mar 28, 2013 | Inside, Research
Ramon E. Parsons, MD, PhD, a highly acclaimed researcher in cancer genetics, has joined Icahn School of Medicine at Mount Sinai as the Ward-Coleman Chair in Cancer, and Chair of the Department of Oncological Sciences.
Dr. Parsons succeeds Stuart Aaronson, MD, Jack and Jane B. Aron Professor, whose significant discoveries in molecular oncology include identifying the first normal function of an oncogene, and its role in growth factor signaling. Dr. Aaronson has been appointed Founding Chair Emeritus of the Department of Oncological Sciences, and will continue to lead his highly funded laboratory at Mount Sinai.
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Updated on Jun 30, 2022 | Inside, Research
A team of researchers at The Mount Sinai Medical Center and elsewhere recently discovered a causative gene for primary torsion dystonia (PTD), which sheds light on the genetic underpinnings of this debilitating movement disorder that affects an estimated 500,000 adults and children in North America. PTD is characterized by repetitive twisting muscle contractions throughout the body.
Drs. Laurie Ozelius and Tania Fuchs
The findings—which appear in the December 9, 2012, issue of Nature Genetics—identified the gene GNAL after exome sequencing was performed on two families with PTD. Further investigation into GNAL revealed six additional mutations of the gene. Exome sequencing is an effective, less expensive alternative to whole genome sequencing.
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Shutting down inflammation within the body, and then harnessing the immune system to recognize and destroy cancer cells, could provide the one-two punch needed to effectively treat head and neck cancers, according to researchers at Icahn School of Medicine at Mount Sinai.