A New Data-Sharing Platform Developed at Mount Sinai Promises to Advance Digital Health Care

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Ashish Atreja, MD, MPH, center, with Bruce Darrow, MD, PhD, Associate Professor of Medicine (Cardiology) and Chief Medical Information Officer, Mount Sinai Health System, left, and Jagat Narula, MD, PhD, Associate Dean for Global Affairs, the Philip J. and Harriet L. Goodhart Professor of Medicine, and editorial board member of Mount Sinai’s upcoming Journal of Digital Medicine Evidence.

A new knowledge and data-sharing platform created by researchers at the Mount Sinai Health System is designed to help physicians weed through the thousands of mobile health apps that enter the market each year and identify the ones that successfully improve patient health. Called NODE Health (Network of Digital Evidence in Health), the platform was created by researchers at Mount Sinai’s AppLab, which is led by Ashish Atreja, MD, MPH, Chief Technology Innovation and Engagement Officer in the Department of Medicine, and Assistant Professor of Medicine (Gastroenterology). NODEHealth.org will provide physicians and other health care providers with an evidence-based review process and data-sharing network that is similar to ClinicalTrials.gov, enabling them to compare studies from around the world to find the health care apps that work best for their specialized needs. (more…)

New Technology That Serves as an Artificial Pancreas Is Revolutionizing the Management of Type 1 Diabetes

New Technology That Serves as an Artificial Pancreas Is Revolutionizing the Management of Type 1 Diabetes

The AP (Artificial Pancreas) system runs an algorithm on a smartphone that communicates with an insulin pump and an implanted glucose sensor.

Research under way at the Icahn School of Medicine at Mount Sinai is revolutionizing the management of type 1 diabetes by using novel technology that serves as an artificial pancreas and automatically enables patients to achieve more stable glucose levels 24 hours a day.

Led by Carol Levy, MD, Associate Professor of Medicine (Endocrinology, Diabetes and Bone Disease), the Icahn School of Medicine is one of nine U.S. and European sites participating in the research, and sharing a $12.7 million grant from the National Institutes of Health. Dr. Levy is one of the study’s lead investigators. (more…)

Breaking New Ground in Multiple Sclerosis Research

Researchers at Mount Sinai’s Corinne Goldsmith Dickinson Center for Multiple Sclerosis played a key role in developing a potential breakthrough treatment for progressive multiple sclerosis (MS), according to findings that were presented in October 2015 at the meeting of the European Committee for Treatment and Research in MS in Barcelona, Spain. The Center also recently received funding to lead a new international coalition tasked with developing a strategy for diagnosing progressive MS earlier. Both efforts further strengthen Mount Sinai’s reputation as a worldwide leader in MS research. (more…)

Big Data Tools Help Decipher Disease Progression

Big Data Tools Help Decipher Disease Progression

The MEGENA tool has 3D spheres that help uncover precise network clusters associated with disease progression.

Two new Big Data analysis tools that help pinpoint specific genes that are actively involved in disease progression were recently made available to the public by scientists in the Multiscale Network Modeling Laboratory at the Icahn School of Medicine at Mount Sinai.

The team, led by Bin Zhang, PhD, Associate Professor in the Department of Genetics and Genomic Sciences, published the pair of algorithm-based tools online in November 2015 in PLoS Computational Biology and in Scientific Reports, a Nature publication. The open-source tools are available to all researchers who wish to gain a better understanding of disease mechanisms in order to develop more effective drugs and create individualized treatments. (more…)

Genetic Testing Under Way in Connecticut

Genetic Testing Under Way in Connecticut

In Mount Sinai’s Branford, Connecticut, laboratory, Research Associate Courtney Pietropaolo prepares DNA samples for sequencing.

In its first full year of operation, the Mount Sinai Genetic Testing Laboratory in Branford, Connecticut, has become an integral part of the Mount Sinai Health System’s efforts to better diagnose and treat disease.

The 16,400-square-foot facility, located 85 miles from New York City, has the high-throughput equipment to sequence thousands of samples monthly to uncover variations in DNA that code for Alzheimer’s and coronary disease, and cancer, among other diseases. (more…)

Study Supports Palliative Care for Cancer Patients

Kavita Dharmarajan, MD, M.Sc

Kavita Dharmarajan, MD, M.Sc

Advanced-stage cancer patients who received palliative care required shorter durations of radiation treatment and had shorter hospital stays, according to a recent study at the Icahn School of Medicine at Mount Sinai.

“Radiation therapy is very effective at relieving pain, but the standard two weeks of treatment may be too long or burdensome for some patients, given the state of their illnesses,” says the study’s senior author, Kavita Dharmarajan, MD, M.Sc, Assistant Professor of Radiation Oncology, and Geriatrics and Palliative Medicine, at the Icahn School of Medicine at Mount Sinai. “We showed that shorter course treatments can be equally, if not more, effective, especially when combined with other forms of therapy that put patients first, and not the tumor.” (more…)

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