Study Finds Distress Among Children in Immigrant Detention

The research team from the Icahn School of Medicine at Mount Sinai included, from left, Priscilla O. Agyeman, MPH, research coordinator, Division of Liver Diseases; Principal Investigator Craig L. Katz, MD; and Sarah MacLean, third-year medical student.

Mount Sinai researchers found that children being held in an immigration detention center experienced high levels of mental health distress, with 44 percent demonstrating at least one significant emotional or behavioral symptom. The report was the first large, empirical study examining the mental health of children in U.S. immigration detention, says the Principal Investigator, Craig L. Katz, MD, Clinical Professor of Psychiatry, Global Health, and Medical Education, Icahn School of Medicine at Mount Sinai.

“Perhaps our findings should not really be a surprise,” says Dr. Katz, who considers the study a valuable baseline for further research. “Kids who had been previously separated from their parents had higher rates of emotional problems, compared to those who were always detained with a parent. And the detained children overall had higher rates of distress compared to the general population in the U.S.”

The research team from Mount Sinai spent two months in summer 2018 at a detention center in the Southwestern United States. speaking to women and children, most of whom had fled Honduras, Guatemala, or El Salvador. The researchers were not allowed to use telephones or take photographs while interviewing the families in a visitation trailer. The study was published in June 2019 in the journal Social Science and Medicine.

The mothers told stories of escaping gang violence or domestic violence in their home countries, where government and police officials often turned a blind eye. The team interviewed 425 women about their eldest child, using the standard Parent-Report Strengths and Difficulties Questionnaire. Among those 425 children, 32 percent had elevated scores for emotional problems, and the rate was 49 percent for those who had previously been separated from their parent. A subset of 150 children who were age 9 or older also completed the UCLA Post-Traumatic Stress Disorder Reaction Index. Seventeen percent of those children had a probable diagnosis of PTSD, compared with 4.7 percent in the general population of U.S. children.

“Children with emotional distress showed symptoms like wanting to cry all the time; problems with conduct, such as fighting with other kids or having temper tantrums; and peer problems like not having a lot of friends or only wanting to interact with adults,” says Sarah MacLean, lead author of the study and a third-year medical student at the Icahn School of Medicine who was part of the field team. “The children with symptoms of PTSD reported having flashbacks or nightmares about a trauma, or feeling depressed or sad.”

The field research for the study was conducted by Kim A. Baranowski, PhD, Associate Director of the Mount Sinai Human Rights Program; Priscilla O. Agyeman, MPH, a research coordinator in the Division of Liver Diseases, Icahn School of Medicine; Ms. MacLean; and Joshua Walther, a fourth-year medical student at the University of Texas Health Science Center in San Antonio, Texas. Authors of the report were the field team; Dr. Katz; and Elizabeth K. Singer, MD, MPH, Assistant Professor of Emergency Medicine, and Medical Education, Icahn School of Medicine, and Director of the Mount Sinai Human Rights Program.

Dr. Katz hopes to expand on the research, which had certain limitations. The subjects were a “convenience sample,” meaning they were the families who were accessible for interviews in the center’s visitation trailer, as opposed to a randomly selected sample. Because of the setting, some mothers completed the forms in their child’s presence, which may have influenced their responses.

The study also could not pinpoint the cause of the children’s distress, whether it was detention, or the journey to the U.S. border, or the violence they faced in their home countries, says Dr. Katz, who is also an Associate Director of the Mount Sinai Human Rights Program. Regardless of the cause, the study concluded that the children “would benefit from culturally responsive and trauma-informed mental health care.” Dr. Katz says that ideally, the mothers and children would receive appropriate psychiatric support once they settle into a community. “But even if they don’t get psychiatric help, social support helps,” he says. “Making sure people have clothes, a backpack, a phone, know how to take a bus. That support is going to make an enormous different in the trajectory of their recovery.”

Despite their higher rates of emotional distress, 98 percent of the children studied had normal scores on the “prosocial” scale, which included being considerate of other’s feelings and volunteering to help others. The team found signs of hope and humanity at the center, a broad expanse of trailers surrounded by a barbed wire fence. One boy from Honduras drew a picture and shyly presented it to Ms. Agyeman, and she intends to keep it forever. “The picture gave me a bittersweet message,” she says, “that a little boy can do the things any other kid would do, laughing and playing, even in an otherwise very sad environment.”

Awards Ceremony Honors Exceptional Mount Sinai Faculty

Back row: Dennis S. Charney, MD, Anne and Joel Ehrenkranz Dean, Icahn School of Medicine at Mount Sinai, and President for Academic Affairs, Mount Sinai Health System, right, and Joanne Stone, MD, MS, Faculty Council President and Professor of Obstetrics, Gynecology and Reproductive Science, left, presided over the Faculty Awards ceremony. Honorees included, front row, from left: Lauren Peccoralo, MD, MPH; Jeffrey Laitman, PhD; Christina Weltz, MD; Nathan Kase, MD; and Chitra Upadhyay, PhD; back row, starting second from left: Juan Wisnivesky, MD, DrPH; Madhav Menon, MD; Gaelle Doucet, PhD; Florian Krammer, PhD; and Ari Greenspan, MD.

The annual Faculty Awards ceremony recently recognized 14 outstanding physicians, researchers, and educators of the Icahn School of Medicine at Mount Sinai. Honorees included senior faculty who have made significant contributions to Mount Sinai and to their fields, as well as junior faculty who have demonstrated exceptional potential in the early stages of their careers in medicine and science.

The Honorees:

Faculty Council Lifetime Achievement Awards: Nathan Kase, MD, Dean Emeritus and Professor of Obstetrics, Gynecology and Reproductive Science; and Jeffrey Laitman, PhD, Distinguished Professor of Medical Education

Faculty Council Senior Faculty Awards: Andrew Hecht, MD (Orthopedics); Florian Krammer, PhD (Microbiology); Christina Weltz, MD (Surgery); and Juan Wisnivesky, MD, DrPH (Medicine)

Faculty Council Junior Faculty Awards: Lauren Peccoralo, MD, MPH (Medicine); and Junqian Xu,PhD (Diagnostic, Molecular and Interventional Radiology)

Dr. Harold and Golden Lamport Research Awards (Basic Research): Ian Maze, PhD (Neuroscience); and Chitra Upadhyay, PhD (Medicine); (Clinical Research): Gaelle Doucet, PhD (Psychiatry); and Madhav Menon, MD (Medicine)

Solomon Silver Award in Clinical Medicine: Ari Greenspan, MD (Medicine)

Special Faculty Council Award of Appreciation: Tanvir Choudhri, MD (Neurosurgery)

 

 

Innovators in Psychiatry

From left: Murad Khan, MD; Annie Hart, MD; Psychiatry Innovation Lab judge Debbie Profit, PhD; Isobel Rosenthal, MD, MBA; and Jordyn Feingold, MAPP, MD/MSCR candidate. Credit: David Hathcox

A group of medical students and residents from the Icahn School of Medicine at Mount Sinai recently won the $10,000 grand prize at the Psychiatry Innovation Lab competition, which was held at the American Psychiatric Association’s annual meeting in San Francisco. At the competition, contestants pitch their ideas to create products or services that promise to transform mental health care.

Annie Hart, MD; Isobel Rosenthal, MD, MBA; Jordyn Feingold, MAPP, MD/MSCR candidate; and Murad Khan, MD, received the grand prize for developing Medimmunity, an online platform that helps medical students and residents survive the stress of medical training.

The project is based on Mount Sinai’s PEERS program, which uses small group sessions to provide medical school students and residents with skills for managing personal and academic challenges. The sessions are held twice a year and are led by a psychiatry resident and a senior medical student who are paired with students during their four years of medical school.

Drs. Hart and Rosenthal and Ms. Feingold are currently at Mount Sinai. Dr. Khan is now a psychiatry resident at the Yale School of Medicine.

Elizabeth Howell, MD, MPP, at TEDMED 2018: How to Improve Care for Pregnant Women

Every year, between 700 and 900 women suffer a pregnancy-related death in the United States. Even more concerning is that a significant portion of these deaths are preventable.

In addition, for every death, more than a hundred women experience a severe pregnancy complication, such as a blood clot, blood transfusion, a hemorrhage, or a seizure during their delivery hospitalization. And significant racial disparities exist in both rates of maternal deaths and severe complications related to pregnancy.

In November 2018, Elizabeth Howell, MD, MPP, the founding Director of The Blavatnik Family Women’s Health Research Institute  at the Icahn School of Medicine at Mount Sinai, gave a TEDMED talk that explored maternal mortality, severe complications of pregnancy, and race in the United States.

“The shocking thing is that our maternal mortality rate in the United States is actually higher than all other high-income countries, and the numbers are far worse for women of color. Our rate of maternal deaths has actually increased over the last decade while other countries have reduced their rates. And here’s the biggest paradox of all: we spend more on health care than any other country in the world.”

In her talk, Dr. Howell, who is also Vice Chair of Research and Professor of Obstetrics, Gynecology and Reproductive Science, and Professor of Population Health Science and Policy, describes current statistics, the magnitude of the racial disparities that exist, and national efforts currently in place aimed at reducing maternal death, severe complications and disparities.

Adolfo García-Sastre, PhD, a Leader in the Study of Viruses, Is Elected to the National Academy of Sciences

“This is a great recognition from my peers,” Adolfo García-Sastre, PhD, says, “not just for me, but for the achievements of all past and present members of my laboratory.”

Adolfo García-Sastre, PhD, Director of the Global Health and Emerging Pathogens Institute, and the Irene and Dr. Arthur M. Fishberg Professor of Microbiology, and Medicine (Infectious Diseases) at the Icahn School of Medicine at Mount Sinai, has been elected to the National Academy of Sciences.

The honor recognizes Dr. García-Sastre’s outstanding contributions to his field, which include developing reverse genetics techniques that revealed the molecular basis of the influenza virus, led to the recreation of the extinct pandemic influenza virus of 1918, and paved the way for improved influenza virus vaccines. His laboratory also defined the role of influenza nonstructural protein 1 (NS1) in dampening the body’s immune response. Dr. García-Sastre says his laboratory’s overarching goal is “to better understand how viruses cause disease, leading to improved prophylactic and therapeutic interventions.” It is working on a universal influenza vaccine that does not require yearly modifications, and on viral therapeutics that target cancerous tumors but do not affect healthy cells.

“Dr. García-Sastre’s research represents the frontier of his field,” says Dennis S. Charney, MD, Anne and Joel Ehrenkranz Dean, Icahn School of Medicine at Mount Sinai, and President for Academic Affairs, Mount Sinai Health System. “The discoveries made by him and others at Mount Sinai will result in powerful new means to combat deadly viruses that affect millions of people and lay the groundwork for discovery of viruses yet unknown.”

Mount Sinai now has three faculty members in the National Academy of Sciences: Dr. García-Sastre; Maria Iandolo New, MD, Professor of Pediatrics, Medicine (Endocrinology), and Genetic and Genomic Sciences; and Peter Palese, PhD, Horace W. Goldsmith Professor and Chair of Microbiology, and Professor of Medicine (Infectious Diseases).

“This is a great recognition from my peers,” Dr. García-Sastre says, “not just for me, but for the achievements of all past and present members of my laboratory.”

Mount Sinai Renames Department of Neuroscience

From left, Paul J. Kenny, PhD; Eric J. Nestler, MD, PhD; benefactors Pamela Nash, Helen Nash, Beth Nash, and Joshua Nash, member, Mount Sinai Boards of Trustees; and Richard A. Friedman, Co-Chairman, Boards of Trustees.

It has been a time of outstanding achievement for the Icahn School of Medicine at Mount Sinai’s Department of Neuroscience—worthy of a celebration.

On Wednesday, May 8, Mount Sinai leadership, benefactors, faculty, and staff attended a reception at the Hess Center for Science and Medicine to unveil the Department’s renaming to the Nash Family Department of Neuroscience, an event held to honor the Nash family for their philanthropic generosity and extraordinary commitment to brain research.

“The Nash family has been supporting critical initiatives at Mount Sinai for more than 40 years and began a focused commitment to advance our neuroscience community more than a decade ago,” says Eric J. Nestler, MD, PhD, Nash Family Professor of Neuroscience, Director of The Friedman Brain Institute, and Dean for Academic and Scientific Affairs at the Icahn School of Medicine at Mount Sinai. “The research that has been made possible through the family’s generosity is being translated into fundamentally new and improved treatments for some of the world’s most devastating brain disorders. We are forever grateful for their commitment to this important work.”

Richard A. Friedman with guests at the reception. A substantial gift from the Friedman family allowed for the creation of The Friedman Brain Institute.

As a direct result of the Nash family’s support, Mount Sinai’s neuroscience program has seen unprecedented growth. Over the past decade, more than 40 basic neuroscience faculty have been recruited to Mount Sinai. Today, the Neuroscience department is ranked No. 1 in the nation among U.S. medical schools in National Institutes of Health (NIH) funding.

“This is testament to the incredible research environment we have created at Mount Sinai with the support of the Nash family,” says Paul J. Kenny, PhD, the Ward-Coleman Professor and Chair of the Department, and Director of Mount Sinai’s Drug Discovery Institute, who has made significant contributions to furthering the understanding of the neurobiological mechanisms of drug addiction and obesity. “With their tremendous support, we have built the depth and breadth of scientific expertise that is required for us to have a real impact in many key areas of brain research. We are translationally focused, so our work is highly relevant to human health and central nervous system disorders. We are also a very close community and we support all of our colleagues, particularly our junior scientists. We foster an environment of research excellence but also one of collaboration and support. As a result, we are second to none when it comes to research funding and scientific impact.”

Helen S. Mayberg, MD, left, with Helen Nash

Groundbreaking work in deep brain stimulation is being conducted in the newly established Nash Family Center for Advanced Circuit Therapeutics, whose founding Director, Helen S. Mayberg, MD, Mount Sinai Professor in Neurotherapeutics, and Professor of Neuroscience, Neurology, Psychiatry, and Neurosurgery, is a pioneer in using brain circuit information to treat neuropsychiatric disorders. She is leading a team to harness the potential of deep brain stimulation—an innovative surgical procedure that has proven successful in treating movement disorders—to address a range of conditions that include depression, addiction, and schizophrenia.

“Additionally, we have researchers who have deep expertise in the mechanisms of gene regulation, and those with demonstrated ability to functionally dissect, manipulate, and understand brain circuitry in the context of complex behaviors,” Dr. Kenny says. “That is where research funding is increasingly directed, and we are on the cutting edge of neurocircuitry research.”

The goal now, Dr. Kenny adds, is to bring together the Department’s key strengths in brain circuitries and mechanisms of gene expression to drive new discoveries related to brain function and its role in disease. “Given the outstanding quality of research in our Department, and the level of NIH funding we have successfully competed for, I believe Mount Sinai is positioned to have a profound impact on human brain health.”

 

Eric J. Nestler, MD, PhD, welcomed guests and spoke about the strengths of the Nash Family Department of Neuroscience.