Pioneering, and Teaching, New Thyroidectomy Technique

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From left: Aida Taye-Bellistri, MD, Assistant Professor of Surgery, Icahn School of Medicine at Mount Sinai; Timo Hakkarainen, MD, Endocrine Surgery Fellow; William B. Inabnet III, MD; Angkoon Anuwong, MD; and Jennifer Barnes, Certified Surgical Technologist, perform the new thyroidectomy procedure for workshop participants.

Surgeons in the Mount Sinai Endocrine Surgery Thyroid Program, who have become national leaders in performing a new minimally invasive technique for thyroidectomy, hosted a workshop in February to train other physicians, a two-day event that drew an audience of clinicians from around the world.

The procedure, known as a transoral endoscopic thyroidectomy (TOETVA), involves the removal of the thyroid gland through small hidden incisions inside the lower lip, an approach that can be used in select cases when traditional thyroidectomy, typically performed through the front of the neck, is not the best course of action. TOETVA is best suited for cases involving smaller nodules and early-stage papillary thyroid cancer.

The workshop was led by William B. Inabnet III, MD, Chair, Department of Surgery, Mount Sinai Beth Israel, and Professor of Surgery, Icahn School of Medicine at Mount Sinai, who performed the first TOETVA in New York State—and only the second in the United States—in September Teams from Duke University Medical Center, Cleveland Clinic, Rush Medical College, and Weill Cornell, as well as from an institute in Mexico City and a hospital in Madrid, attended the workshop in person or via video conference. The event was organized to welcome Angkoon Anuwong, MD, Department of Surgery, Police General Hospital, in Bangkok, Thailand, who developed the technique and last year trained Dr. Inabnet and Gustavo Fernandez- Ranvier, MD, Assistant Professor of Surgery, Icahn School of Medicine at Mount Sinai.

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William B. Inabnet III, MD, and Angkoon Anuwong, MD, front row left, and center, respectively, with some of the workshop attendees.

The TOETVA approach is the latest of three remote access, or “hidden-scar,” endoscopic thyroidectomy techniques to be pioneered by Mount Sinai physicians. The robotic bilateral axillo-breast (BABA) approach was performed for the first time in the United States in 2015 at Mount Sinai Beth Israel, by Hyunsuk Suh, MD, Assistant Professor of Surgery. It involves four small incisions to the breasts and axilla (underarms) and is an option for larger thyroid glands and select cases of thyroid cancer. (Dr. Suh also performed the first BABA lymph node dissection for thyroid cancer in January 2017.) In the transaxillary approach, one incision is made in the underarm, which allows the thyroid gland to be reached from the side. Mount Sinai is the only institution in the United States, and one of only a few in the world, to offer all three types of hidden-scar thyroid procedures.

“The addition of the transoral route with the introduction of TOETVA is a natural evolution of our growing program and our interest in these minimally invasive approaches,” says Dr. Inabnet.

While workshop attendees received an overview on the BABA and transaxillary techniques, TOETVA was the focal point of instruction, which included a live surgery demonstration of two TOETVA cases. The Mount Sinai Endocrine Surgery Thyroid Program plans to host three additional workshops in March, June, and July.

“Mount Sinai’s reputable standing in the field of minimally invasive surgery is a result of the work being done across multiple divisions within the Health System,” says Michael L. Marin, MD, the Dr. Julius H. Jacobson II Chair in Vascular Surgery and Surgeon-in-Chief at the Mount Sinai Health System. “We are proud to bring TOETVA to the American population and further establish the Health System’s commitment to providing care that is consistently on the forefront of surgical innovation.”

Angela Diaz, MD, PhD, MPH, is Elected to Leadership Role in the National Academy of Medicine

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Angela Diaz, MD, PhD, MPH

Angela Diaz, MD, PhD, MPH, a leader in adolescent medicine, has been elected to the governing Council of the National Academy of Medicine. Membership in the Academy reflects major contributions to the medical sciences, health care, and public health. The group’s Council members, who serve three-year terms, are elected by their peers.

A member since 2008 of the Academy and its predecessor, the Institute of Medicine of the National Academies, Dr. Diaz is the Jean C. and James W. Crystal Professor in Adolescent Health; Professor of Pediatrics, and Environmental Medicine and Public Health, at the Icahn School of Medicine at Mount Sinai; and Director of the Mount Sinai Adolescent Health Center. Under the leadership of Dr. Diaz, the Center has become one of the nation’s largest adolescent health centers, known for outstanding research and training, and for serving more than 10,000 vulnerable youths each year with care that is free of judgment, free of charge, and completely confidential.

Dr. Diaz is a national and international leader in her field, says a longtime mentor, Kurt Hirschhorn, MD, Professor Emeritus of Pediatrics, Genetics, and Medicine, and Chairman Emeritus of Pediatrics, Icahn School of Medicine at Mount Sinai. “She was so impressive that I recruited her to our high school program for teenagers interested in careers in medicine and health science. When she finished medical school, I recruited her as a resident in Pediatrics and later as a fellow in adolescent medicine. The rest is history. She is a member of the highest organization in medicine, and is now becoming one of its leaders.”

Dr. Diaz, who will join about 20 Council members governing the National Academy of Medicine, says, “I’m honored to have been elected to serve on the Council of such an esteemed organization that is a trusted resource for the nation.”

A Collaboration Between Mount Sinai and CityMD Aims to Enhance Quality and Access to Care

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Arthur Klein, President of the Mount Sinai Health Network

The Mount Sinai Health System and CityMD have launched a joint collaboration to enhance and expand urgent care services throughout New York City, a partnership that will combine Mount Sinai’s vast network of providers and CityMD’s urgent and clinical care management expertise to create a unique model of timely access to health care.

Significantly, the relationship allows CityMD patients access to Mount Sinai providers, when needed, for prompt follow-up care with a primary care physician or a specialist for further treatment or management of chronic conditions. Provider access includes all Health System hospitals, faculty at the Icahn School of Medicine at Mount Sinai, and other Mount Sinai-associated physicians.

Says Arthur Klein, President of the Mount Sinai Health Network: “This collaboration will establish a more comprehensive model that meets the full spectrum of health care needs of patients throughout the city. We look forward to achieving significant milestones with CityMD.”

The partnership also provides an added benefit to Health System staff enrolled in a Mount Sinai health plan. As a member of the Health System network, CityMD is now a “top tier” provider in the employee health plan. Enrolled employees will have zero or lower copays, depending on their plan, as well as no deductibles, when receiving care from a CityMD practice. Founded in 2010, CityMD now has more than 50 practice locations in the tri-state area.

Under the collaboration, both parties will also share electronic medical records and establish quality metrics to further improve patient outcomes and reduce health care costs.

Previously Unknown Microbes in Humans May Provide Extra Immune Protection

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Study authors include, from left: Miriam Merad, MD, PhD; graduate student Aleksey Chudnovskiy; and Veronika Kana, postdoctoral fellow, MD, PhD.

The discovery of a novel type of microbe found in laboratory mice at the Icahn School of Medicine at Mount Sinai has shed new light on the existence of similar organisms in humans, which may help boost the immune system and protect against food-borne toxins, such as salmonella.

Scientists led by Miriam Merad, MD, PhD, Director of the Immunology Institute at the Icahn School of Medicine, described the discovery of the mouse microbe—called Tritrichomonas musculis (T. mu)—in the October 6, 2016, issue of Cell. Their findings suggest that a previously unknown set of single-cell organisms, or protists, which belong to a different biological classification than bacteria, live in the guts of mice and influence their immune system.

The significance of the Mount Sinai study was featured in a subsequent blog by Francis S. Collins, MD, PhD, Director of the National Institutes of Health, who commented: “Recently, we humans have started to pay a lot more attention to the legions of bacteria that live on and in our bodies because of research that’s shown us the many important roles they play in everything, from how we efficiently metabolize food to how well we fend off disease. As it turns out, bacteria may not be the only interior bugs with the power to influence our biology positively.”

Prior to the new findings, scientists considered protists similar to T. mu to be disease-carrying parasites. In fact, T. mu seemed to increase the number of tumors in mice with a genetic susceptibility for colon cancer and it increased weight loss and tissue damage in mice with preexisting inflammatory disease. But, the inflammation caused by a rapid increase in immune cells—dendritic and T cells—brought about by T. mu, led to beneficial results for mice, overall.

“Protists probably aren’t all bad when it comes to our health,” according to Dr. Collins. “As in the laboratory mice, they may afford us with extra immune protection, which could be especially beneficial for those living in parts of the world where infectious disease is an ever-present threat.”

Mount Sinai’s scientific team also included investigators from the National Institute of Allergy and Infectious Diseases, and Universidad del Rosario, Bogotá, Colombia. The study found that humans from around the world harbor a related microbe, Dientamoeba fragilis (D. fragilis). This protist—taken from the fecal samples from people in South America, Africa, Europe, and Asia—has been associated with irritable bowel syndrome, but its effects are not completely clear.

The scientists theorized that the absence of this microbe could also explain why some people are more susceptible to certain infections than others. In recent years, advances in DNA sequencing technologies have enabled scientists to identify and study previously unknown microbes that could not be studied in traditional laboratories for various reasons. This new field of study of the human microbiome aims to characterize these microbes and understand their role in supporting health and triggering disease.

“The most important result in this study is the finding that a nonbacterial bug in our flora could potentially protect from severe intestinal infections,” says Dr. Merad. “This illustrates the need to study non-bacterial species of the microbiome, including protists, which remain very prominent in the developing world.” Further study, she adds, will likely identify novel “crosstalks” or interactions between the microbiome and immune cells that impact health and disease.

Mount Sinai Brings Transplant Team and Decades of Experience to Long Island

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Sander S. Florman, MD, Director of The Recanati/Miller Transplantation Institute at Mount Sinai

The Recanati/Miller Transplantation Institute at Mount Sinai is now offering complete transplant evaluation services at the Mount Sinai Doctors Long Island Five Towns practice in Hewlett, N.Y.  At this new satellite practice, adult patients who need a liver or kidney transplant can be seen by an entire multidisciplinary transplant team from Mount Sinai.  All aspects of transplant care except for the actual operation can now take place locally, providing convenience for patients as well as confidence that they are being cared for by a highly experienced team of experts.

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Learn more about The Recanati/Miller Transplantation Institute at Mount Sinai

The Lancet: US Health-Care Groups Voice Concerns About Replacing ACA

2col-reichleadershipAbout 2 million people in New York could lose coverage if funding to expand Medicaid eligibility ended, David Reich, MD, President and Chief Operating Officer of The Mount Sinai Hospital, tells The Lancet. If that happens, Reich said “we lose our ability to use the new and innovative programs” the ACA facilitates. The ACA has started to move the health-care delivery system “toward one that’s preventive in nature rather than reactive and disease-based,” he said. Provided in outpatient settings, preventive care saves money and keeps patients healthy.

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