Harvard Business Review: How Mount Sinai Health System Fosters Collaboration to Fight Cancer

Samir Parekh, MD

In an article published in the Harvard Business Review, Joel Dudley, PhD, Mount Sinai Professor in Biomedical Data Science at the Icahn School of Medicine at Mount Sinai and Executive Vice President for Precision Health for the Mount Sinai Health System, and Samir Parekh, MD, Associate Professor, Medicine (Hematology and Medical Oncology), and Oncological Sciences, write about the unique partnership between researchers and doctors at Mount Sinai who are using advanced computer analytics to treat blood and bone marrow cancers.

Joel Dudley, PhD

“The Mount Sinai Health System is organized differently from most, as one integrated institution. Doctors from the seven Mount Sinai hospitals work side by side with researchers from the Icahn School of Medicine at Mount Sinai,” the authors write.

“Indeed, many clinicians also have Sinai research labs. If a clinician and a researcher devise a viable idea to solve a medical problem, they are free to join forces and pursue the project. This makes it possible to rapidly bring a finding from the lab bench to the patient bedside.”

Read the full article in the Harvard Business Review

Sixth Episode of Mount Sinai Future You

The sixth episode of Mount Sinai Future You highlights inspirational stories and features a young man’s journey following a horrific car accident that left him paralyzed. With the help of the exoskeleton program, Thomas Bryce, MD, Director of the Spinal Cord Injury Program at Mount Sinai, and Angela Riccobono, PhD, Senior Clinical Psychologist of Rehabilitation Medicine at Mount Sinai, he was able to participate in the 2018 New Balance 5th Avenue Mile Race sponsored by the New York Road Runners.

Mount Sinai Future You, which highlights innovation at Mount Sinai, is being broadcast on CUNY TV, the non-commercial educational-access cable channel run by The City University of New York.

Mount Sinai Future You takes viewers behind the scenes as doctors at Mount Sinai Health System leverage innovative science to change patients’ lives every day. The series  highlights preventative care and treatment models that will lead to better health and longer lives.

 Mount Sinai Future You, Episode Six, also features:

  • Keith J. Benkov, MD, Associate Professor of Pediatrics at the Icahn School of Medicine at Mount Sinai and the Mount Sinai Kravis Children’s Hospital, and a patient with Crohn’s disease bond over their love of running.
  • Marla C. Dubinsky, MD, Chief of Pediatric Gastroenterology and Hepatology at Mount Sinai Kravis Children’s Hospital, dedicates her time to helping young patients with Crohn’s disease live comfortable and normal lives.
  • Lisa M. Satlin, MD, Chair of Pediatrics at Mount Sinai Kravis Children’s Hospital, and Jeffery M. Saland, MD, Chief of the Division of Pediatric Nephrology and Hypertension at Mount Sinai, diagnose an infant with a rare heart defect that would save her life with only minutes to spare.
  • Barry Love, MD, Assistant Professor in the Division of Cardiology in the Jack and Lucy Clark Department of Pediatrics at the Icahn School of Medicine and Mount Sinai Kravis Children’s Hospital, uses a tiny, wireless pacemaker to help a teenager with a congenital heart condition continue his love of travel and adventure.
  • Harsha Reddy, MD, Oculoplastic Surgeon at New York Eye and Ear Infirmary of Mount Sinai, uses his delicate touch in the operating room to preserve a patient’s eyesight.
  • Carlos Cordon-Cardo, MD, PhD, Chairman of the Department of Pathology at the Mount Sinai Health System, and Gerardo Fernandez, MD, Director of Precise MD at the Icahn School of Medicine, use precision medicine to more accurately diagnosis prostate cancer.
  • This year marks the 50th anniversary of the Icahn School of Medicine. David L. Reich, MD, President and Chief Operating Officer of The Mount Sinai Hospital, shares his journey as an alumni of the school.

New episodes of Mount Sinai Future You will run during the first week of each month, rerunning on Wednesday, Thursday, and Saturday. You can find CUNY TV here:

  • Spectrum, Cablevision and Optimum Brooklyn: Channel 75
  • RCN Cable: Channel 77
  • Verizon FiOS: Channel 30

Kenneth L. Davis, MD, President and CEO of Mount Sinai, in LEADERS Magazine: Consistent Quality

In an interview with LEADERS magazine, Kenneth L. Davis, MD, President and Chief Executive Officer of the Mount Sinai Health System, talks about the keys to Mount Sinai’s consistent strength and leadership in the industry, how the role of the hospital is evolving, and other current topics.

“The brand has always stood for consistent quality, even when faced with the most complex conditions. We continue to make that the highest priority as we take care of the sickest people, regardless of their backgrounds, and get the best possible outcomes,” Dr. Davis says in the interview. “Innovation goes hand-in-hand with that. Our innovation is fostered by the fact that our hospital gave birth to our medical school. The dean of the medical school doesn’t report to a university but to a health system. It’s easier to keep innovation at the forefront of the health system when there is a medical school right behind it.”

See the full interview in LEADERS magazine

Read the article [PDF]

Class of 2022 Takes Its Place in the Field of Medicine

Students celebrated at the White Coat Ceremony.

One hundred forty medical students who constitute the Icahn School of Medicine at Mount Sinai’s Class of 2022 were welcomed into the medical profession on Thursday, September 13, at the school’s symbolic White Coat Ceremony in Stern Auditorium. Surrounded by family members, alumni, and Mount Sinai Health System leaders, the students proudly received their white coats and recited an oath they had written to accept the privilege and responsibility being bestowed upon them as society’s future physicians.

Peter W. May, Chairman, Boards of Trustees, Mount Sinai Health System, told the audience that the medical school was unique in that it was founded 50 years ago by a hospital, rather than a large university. “What we care about is creating research that gets applied to the clinic as quickly as possible to help our patients,” he said. “You are receiving your white coats today because your clinical training starts right at the beginning of your medical education. At Mount Sinai, you will have the opportunity to learn and work with brilliant professors in math, computer science, engineering, and the physical sciences. This interdisciplinary collaboration extends the boundaries of what modern medicine can achieve.”

Kenneth L. Davis, MD, President and Chief Executive Officer of the Mount Sinai Health System, encouraged the students to take the time to explore the many research and clinical opportunities the school has to offer in order to find an area of medicine they love. He said Mount Sinai’s commitment to helping students find their passion is the same as it was nearly 50 years ago, when he entered the school’s second class.

During the ceremony, students Dillan Villavisanis, left, and Vivek Vishwanath received their white coats from Medical Education Faculty Advisors Olanrewaju Dokun, MD, left, and Caroline Cromwell, MD.

“You have earned the right to be here. You have the capacity to be great,” Dr. Davis told the students. “Let today be remembered as the day you committed to achieve that greatness by searching for that part of this worthy profession that lights an unquenchable fire in you. That takes time.”

Dennis S. Charney, MD, Anne and Joel Ehrenkranz Dean, Icahn School of Medicine at Mount Sinai, and President for Academic Affairs, Mount Sinai Health System, said the high academic achievements, skills, and interests among the Class of 2022 were evidence of their potential to become the “next generation of brilliant physicians, transformative scientists, and leaders who will shape the future of education, biomedical research, and delivery of high quality care to all Americans.”

Dr. Charney said the ability to change the field of medicine would belong to only a talented few, including the Class of 2022. This, he said, brought to mind the famous 1940 speech by the British Prime Minister Winston Churchill, who said of the Royal Air Force during the Battle of Britain, “Never in the field of human conflict was so much owed by so many to so few.”

The white coat, said Dr. Charney, comes with “serious responsibilities. Patients will ask you for answers, and sometimes the answers are not forthcoming. Class of 2022, there are only 140 of you, yet there are so many patients in our local community, our city, our country, our world who are going to need you.”

On the occasion of its 50th anniversary this year, the Icahn School of Medicine inaugurated the first Hans Popper, MD, PhD, Keynote Speaker at the White Coat Ceremony, and extended this honor to 2009 Mount Sinai alumnus Pooja Mehta, MD, MSHP, Assistant Professor, Obstetrics and Gynecology at Louisiana State University School of Medicine. Dr. Mehta also serves as Director of Women’s Health Policy and interim Chief Medical Officer of Medicaid for the state of Louisiana.

Dr. Mehta relayed the story of a very ill woman she once treated who taught her how important it is to understand the patient. She said, this woman—whose tragic health outcome was largely preventable—ultimately led her to Louisiana where she cares for underserved women, as well as transgender and gender non-conforming individuals, “who seek self-determination in health care.”

“You will have all the tools you need when you leave here to question, to think critically, to evaluate evidence, to work in a hospital, and to work outside the four walls of a hospital,” said Dr. Mehta. “Use every drop of privilege this white coat gives you. But don’t wait too long to divest from your privilege to meet the people where they are, and—as stated in the Oath of Maimonides that I took in this room 14 years ago—to be a fellow creature in pain.”

$7.6 Million Grant Awarded for Multifaceted Study of Peanut Allergy

From left: principal investigators Cecilia Berin, PhD; and Scott Sicherer, MD; with Supinda Bunyavanich, MD, MPH, leader of the genomic and data-science arm of the project.

When patients are diagnosed with peanut allergy, they often ask two questions: “How much peanut can I eat before I get sick, and how severe will the reaction be?” says Scott Sicherer, MD, Director, Elliot and Roslyn Jaffe Food Allergy Institute, Icahn School of Medicine at Mount Sinai. And physicians have another question, he says: “If I recommend a therapy, is it going to work for this patient?” These questions are at the center of research funded by a five-year, $7.6 million grant from the National Institute of Allergy and Infectious Diseases that was recently awarded to a multidisciplinary team at the Icahn School of Medicine.

The research is divided into three projects, which reflect Mount Sinai’s unique strengths in clinical allergy treatment, basic science, and data-driven medicine. Cecilia Berin, PhD, Deputy Director of the Jaffe Food Allergy Institute, and Professor of Pediatrics, and Dr. Sicherer are principal investigators of the National Institutes of Health grant.

The central project is a clinical trial that will focus on a seldom-studied group—people with “high-threshold” peanut allergy, meaning they react only to larger amounts of peanut. This trial of a dietary allergy immunotherapy will be led by Dr. Sicherer, the Elliot and Roslyn Jaffe Professor of Pediatric Allergy and Immunology, and Chief of Pediatric Allergy; and Anna Nowak-Wegrzyn, MD, PhD, Professor of Pediatrics. “Most studies right now are looking at people who are exquisitely allergic—people who react to a fraction as small as a 50th of a peanut,” Dr. Sicherer says. “But a majority of people with peanut allergy do not react to these tiny amounts, and the treatments so far have not really been directed to them. This study is trying to identify those people and then see if an immunotherapy would help them, possibly to a cure.”

Researchers will conduct “food challenges” of about 200 children ages 4 to 14, giving them small doses of peanut. They plan to identify 98 high-threshold children, who will be divided into two groups. One group will simply avoid peanut, and the other will eat small amounts of peanut butter—carefully measured by parents—starting with about 1/8 teaspoon and progressing to larger servings. The aim is to reduce, or even eliminate, their sensitivity to peanut.

Anna Nowak-Wegrzyn, MD, PhD, gave patient Gabriella Evans a small dose of peanut, a therapy that will be further studied in an upcoming clinical trial.

The other two projects will analyze blood samples from all 200 children. “We have developed advanced tools for studying many parameters of the allergic response to peanut using small amounts of blood,” says Dr. Berin. “In my project, the idea is understanding the immune pathways that affect peanut allergy overall and the immune basis of outgrowing peanut allergy in response to allergen immunotherapy.”

The third project will take a genomic and data-science approach, using Mount Sinai’s high-performance computing resources. It is led by Supinda Bunyavanich, MD, MPH, Associate Director of the Jaffe Food Allergy Institute, and Associate Professor of Genetics and Genomic Sciences, and Pediatrics. “We will sequence blood samples from the children participating in this trial and use data science to identify novel biomarkers for peanut-allergy management,” Dr. Bunyavanich says. “Our goal is to find biomarkers that predict reaction threshold and desensitization potential in peanut-allergic individuals. The project will also further our mechanistic understanding of peanut allergy severity.”

Overall, the objective is to develop more effective, personalized immunotherapies for peanut allergy and to determine which patients are the best candidates before any treatment starts. “Peanut allergy is a very common food allergy—it affects about 2 percent of kids,” Dr. Sicherer says, “and this research will have a big impact on how we treat these patients.”

Courtside at the 2018 US Open

At the US Open, from left: James Gladstone, MD; Melissa Leber, MD, Assistant Professor of Orthopedics, and Emergency Medicine; Leesa M. Galatz, MD; Alexis Colvin, MD; and Aruna Seneviratne, MD, and Shawn Anthony, MD, each an Assistant Professor of Orthopedics.

Top orthopedic surgeons, sports medicine physicians, and musculoskeletal radiologists were courtside to help diagnose and provide rapid professional care to athletes in need of medical attention at the 2018 US Open Tennis Championships. It was the sixth consecutive year that Mount Sinai has served as the official medical services provider of the event, which was held over a two-week span in August and September in Flushing Meadows, Queens.

Alexis Colvin, MD, Associate Professor of Orthopedic Surgery in the Leni and Peter W. May Department of Orthopedic Surgery, Icahn School of Medicine at Mount Sinai, led player care as the Chief Medical Officer of the 2018 US Open. “We treated not only the pros, but the juniors and wheelchair athletes, as well,” says Dr. Colvin, who is also the U.S. Fed Cup team physician.

An ad from Mount Sinai’s 2018 US Open ad campaign.

This year marked many tournament firsts for Mount Sinai, which hosted the first-ever “Mount Sinai Get Fit and Play” event for the 23rd annual Arthur Ashe Kids’ Day, featuring fun, physical activities for youth. On hand to support the event were members of the sports medicine team and Leesa M. Galatz, MD, Mount Sinai Professor in Orthopedics and Chair of the Leni and Peter W. May Department of Orthopedic Surgery.

“Promoting the sport of youth tennis as a means to stay fi t and healthy is a critical component of our partnership with the United States Tennis Association (USTA),” says James Gladstone, MD, Chief of the Mount Sinai Health System’s Sports Medicine Service, Associate Professor of Orthopedic Surgery at the Icahn School of Medicine at Mount Sinai, US Open Player Physician, and U.S. Davis Cup team physician.

Also for the first time, Joseph Herrera, DO, Chair, Department of Rehabilitation Medicine and Human Performance, and the Lucy G. Moses Professor of Rehabilitation Medicine, along with a team of rehabilitation medicine specialists, participated in Community Day, hosting 32 Mount Sinai patients at the US Open Wheelchair Competition. There, they had a special courtside opportunity to experience the excitement of wheelchair tennis and meet players.

Two wheelchair stars—four-time Paralympic medalist and International Tennis Federation’s Quad World Champion, David Wagner, and Rio 2016 Paralympian Dana Mathewson—also visited Mount Sinai Kravis Children’s Hospital, where they filmed a segment for KidZone TV, talking about their experience with the sport and its role in their rehabilitation. They later conducted a live demonstration of wheelchair tennis and basic tennis drills for Mount Sinai rehabilitation patients in the Guggenheim Pavilion Atrium, much to the delight of patients and spectators.

Wheelchair tennis stars David Wagner and Dana Mathewson showed their skills.

Mount Sinai radiologists, led by Carlos Benitez, MD, Director of Musculoskeletal Imaging at Mount Sinai West and Mount Sinai St. Luke’s, and Associate Professor of Radiology at the Icahn School of Medicine,were also onsite working closely with the team of Mount Sinai’s orthopedic sports medicine specialists. They provided players with immediate access to on-the-spot evaluation, diagnosis, and treatment of injuries. A portable, laptop-size ultrasound device made by GE Healthcare was used to diagnose musculoskeletal injuries. Also adding to their capabilities for the first time this year was a portable X-ray machine, the GE Optima 200, outfitted with a Konica Minolta Digital Detector providing high-definition digital images of the chest, pelvis, spine, or extremities that could be interpreted by radiologists onsite.

The Mount Sinai Health System also achieved another milestone during the tournament when it launched its first marketing campaign in support of its partnership with the US Open and the USTA Eastern Section. It included highly visible billboards in Lower Manhattan, ads in The New York Times Magazine, digital and social media displays, and ads on the Long Island Railroad, MetroNorth, and subway.

While the ads had a distinct tennis theme and reinforced Mount Sinai’s relationship with the US Open, they also conveyed the broad message that “Mount Sinai is a full-service health system that can not only treat your injury, but also treat the rest of your body.” In mid-October, Mount Sinai will launch a larger six-month ad campaign that will showcase its world renowned excellence in many other disciplines.

Children kept fit at Arthur Ashe Kids’ Day.

 

 

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