Mount Sinai Steps Up for Pride Month

Mount Sinai Queens staff, family, and friends at the Queens Pride parade.

The Mount Sinai Health System observed Pride Month and the 50th anniversary of the Stonewall uprising with festive events in June. Contingents from Mount Sinai took part in the Queens Pride parade on Sunday, June 2, and in the NYC Pride parade in Manhattan on Sunday, June 30. At Pride fairs throughout the month, staff of LGBT Health Services, the Institute for Advanced Medicine, and the Mount Sinai Adolescent Health Center distributed free condoms, informational pamphlets, and fun favors.

On Thursday, June 27, about 400 attended Mount Sinai’s Pride Celebration at the House of Yes venue in Brooklyn. “We have the largest representation in LGBTQ health delivery in the New York City area, and what we do saves lives every day,” David L. Reich, MD, President of The Mount Sinai Hospital and Mount Sinai Queens, told the attendees. “The reason we are such an amazing health system is because of all of you.”

 

David L. Reich, MD, President of the Mount Sinai Hospital and Mount Sinai Queens, center, with, from left,  Gary C. Butts, MD, Chief Diversity and Inclusion Officer, and Dean for Diversity Programs, Policy and Community Affairs, Icahn School of Medicine at Mount Sinai; Pamela Y. Abner, MPA, CPXP, Vice President and Chief Administrative Officer; Barbara Warren, PsyD, Director, LGBT Programs and Policies; and Edgar Vargas, MPH, LMSW, LGBT Program Manager.

Mount Sinai Doctors Astoria staff members at Queens Pride, from left: Shirmira Wilson, Kathleen Meza, and Madelyn Penagos.

An aerialist performed during the Pride Celebration at the House of Yes venue in Brooklyn.

At the Pride Celebration, Joshua Safer, MD, Executive Director of Mount Sinai’s Center for Transgender Medicine and Surgery, right, with Katharine K. Williams, PhD, a clinical psychologist at the Center.

Staff members, from left: Janice Yoon, program manager; Elizabeth Diaz, MPA, senior project coordinator; Shana Dacon, MPH, MBA; Edgar Vargas, MPH, LMSW, LGBT program manager; and Samuel Rosado, project coordinator.

The Mount Sinai Health System’s contingent at NYC Pride.

Medical Experts Separate Fact From Fiction at Dubin Breast Center’s Annual Luncheon and Symposium

From left: Elisa Port, MD, FACS; Isabel S. Blumberg, MD; Stafford R. Broumand, MD; Hanna Y. Irie, MD, PhD; Laurie Margolies, MD, Director of Breast Imaging, Dubin Breast Center; Jeffrey Mechanick, MD, Professor of Medicine (Cardiology, Endocrinology, Diabetes and Bone Disease); and Hank Schmidt, MD, PhD.

Are breast implants safe? Do oral contraceptives increase your risk for breast cancer? These were among the questions answered by a panel of physicians in May, at the seventh annual Dubin Breast Center Fact vs. Fiction Luncheon and Symposium that was held in Manhattan.

The sold-out event featured the latest information on breast cancer from six doctors at the Icahn School of Medicine at Mount Sinai and was moderated by Elisa Port, MD, FACS, Director of the Dubin Breast Center and Chief of Breast Surgery, Mount Sinai Health System. The goal of the annual luncheon is to clarify information about one of the most common cancers in women worldwide, so patients can keep up with advances and make informed decisions about their health.

“There is no one who gets a diagnosis of breast cancer who doesn’t think it’s the worst day of their life, the worst thing that’s happened to them, and the question of mortality always comes up,” Dr. Port said at the luncheon. “But let me be crystal clear that with a diagnosis of breast cancer there is so much room for optimism in 2019. For most cases, we are saying you have a 90 percent chance of survival. In some cases, a 98 percent or 99 percent chance of survival. This is success.”

Dr. Port said the development of “a few key drugs” over the past decade has led to increased survival rates. “What we need to work on are the outliers that don’t respond well. That continues to be the reason we get up every morning and sit in the lab and look for better treatments,” she added. “You will hear more from us, because we are on it.”

The following questions and answers were among those included at the luncheon.

Do birth control pills increase my risk for breast cancer?

Isabel S. Blumberg, MD, Clinical Instructor, Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine: Yes. Even newer ones slightly increase the risk for breast cancer. The risk is very small. Someone who has had breast cancer is not a candidate for oral contraceptives. But there is a nonhormonal IUD that is really safe, lasts for 10 years, and works extremely well, so that may be the answer. A new diaphragm that is universally sized is coming to market, and condoms are always an option.

 Are breast implants safe?

Stafford R. Broumand, MD, Associate Clinical Professor of Plastic Surgery, Icahn School of Medicine: Silicone implants are safe. But there are issues that need to be clarified. Different types of implants have different types of issues. Lately, anaplastic large cell lymphoma (ALCL) has been diagnosed in women with textured implants. We don’t really know why that is. We now use smooth implants because there is no incidence of ALCL. Women who have textured implants and those who are not sure whether they have them should discuss this with their physician.

Can a liquid biopsy detect cancer cells in the blood of someone who is not known to have breast cancer or determine if a patient’s cancer is returning? Can it also be used to track a patient’s response to treatment?

Hanna Y. Irie, MD, PhD, Associate Professor of Medicine (Hematology and Medical Oncology), and Oncological Sciences: A liquid biopsy is a blood test aimed at detecting small amounts of cancer cells circulating in the blood stream, as well as the footprint, or DNA, of these cancer cells. Most studies use the biopsy in the context of advanced cancers. However, because of the power of liquid biopsy in detecting small amounts of cancer, researchers at the Dubin Breast Center are trying to understand its utility in patients diagnosed with triple negative aggressive breast cancer. We are studying whether it can detect recurrences at an earlier stage than either CT scans or MRIs.

 What is the right screening for me based on my family history?

Hank Schmidt, MD, PhD, Associate Professor of Surgery, Director, High-Risk Program at the Dubin Breast Center: The big question is ‘what is your risk?’ There are a lot of ways to risk stratify patients to find out where they lie on the spectrum of risk. Some patients have a strong family history of cancer but their genetic testing is negative. We look at a variety of risk factors. Then we define a plan for risk management. A big component of our surveillance is imaging. For women over age 40 mammography is the standard. We always begin with that. Then, based on personal risk, we decide whether to add ultrasound on a yearly basis, or for higher-risk patients or someone who wants to be more aggressive, we’ll consider adding annual breast MRI.

Adolfo García-Sastre, PhD, a Leader in the Study of Viruses, Is Elected to the National Academy of Sciences

“This is a great recognition from my peers,” Adolfo García-Sastre, PhD, says, “not just for me, but for the achievements of all past and present members of my laboratory.”

Adolfo García-Sastre, PhD, Director of the Global Health and Emerging Pathogens Institute, and the Irene and Dr. Arthur M. Fishberg Professor of Microbiology, and Medicine (Infectious Diseases) at the Icahn School of Medicine at Mount Sinai, has been elected to the National Academy of Sciences.

The honor recognizes Dr. García-Sastre’s outstanding contributions to his field, which include developing reverse genetics techniques that revealed the molecular basis of the influenza virus, led to the recreation of the extinct pandemic influenza virus of 1918, and paved the way for improved influenza virus vaccines. His laboratory also defined the role of influenza nonstructural protein 1 (NS1) in dampening the body’s immune response. Dr. García-Sastre says his laboratory’s overarching goal is “to better understand how viruses cause disease, leading to improved prophylactic and therapeutic interventions.” It is working on a universal influenza vaccine that does not require yearly modifications, and on viral therapeutics that target cancerous tumors but do not affect healthy cells.

“Dr. García-Sastre’s research represents the frontier of his field,” says Dennis S. Charney, MD, Anne and Joel Ehrenkranz Dean, Icahn School of Medicine at Mount Sinai, and President for Academic Affairs, Mount Sinai Health System. “The discoveries made by him and others at Mount Sinai will result in powerful new means to combat deadly viruses that affect millions of people and lay the groundwork for discovery of viruses yet unknown.”

Mount Sinai now has three faculty members in the National Academy of Sciences: Dr. García-Sastre; Maria Iandolo New, MD, Professor of Pediatrics, Medicine (Endocrinology), and Genetic and Genomic Sciences; and Peter Palese, PhD, Horace W. Goldsmith Professor and Chair of Microbiology, and Professor of Medicine (Infectious Diseases).

“This is a great recognition from my peers,” Dr. García-Sastre says, “not just for me, but for the achievements of all past and present members of my laboratory.”

Road to Resilience Episode 13: Forget Kumbaya –The Art of Self-Care

Cardinale Smith, MD, PhD

Overwhelmed by grief for patients who had died, Cardinale Smith, MD, PhD, an oncology fellow, embarked on a self-care journey that led to unexpected places.

In episode 13 of Road to Resilience, Dr. Smith, Director of Quality for Cancer Services at the Mount Sinai Health System, shares the ritual she uses to process loss, offers tips on having hard conversations, and reflects on the end of life.

Oncologists and palliative care specialists commonly experience patient loss and are often affected by unprocessed grief. An approach to mitigate the emotions is self-care; having a self-care and self-awareness plan is crucial when caring for patients with life-limiting cancer.

Road to Resilience brings you stories and insights to help you thrive in a challenging world. From fighting burnout and trauma to building resilient families and communities, the podcast explores what’s possible when science meets the human spirit. To listen, visit Apple PodcastsSpotifyStitcherGoogle Play, or the Road to Resilience website.

At 50th Commencement, a Call to Engage in Health Issues

Commencement speaker Scott Gottlieb, MD, center, with Mount Sinai Health System leaders Kenneth L. Davis, MD, left, and Dennis S. Charney, MD.

A former chief of the U.S. Food and Drug Administration (FDA), a leader in the study of cardiovascular and liver disease, a football player turned philanthropist, and an educator who is advancing the teaching of science and medicine were honored as the Icahn School of Medicine at Mount Sinai celebrated its 50th Commencement.

The Icahn School of Medicine granted 101 MDs, 34 PhDs, and 22 dual degrees at the ceremony held on Thursday, May 9, at David Geffen Hall, Lincoln Center. Scott Gottlieb, MD, the 23rd commissioner of the FDA and a 1999 graduate of the Icahn School of Medicine, delivered the commencement address to the 3,000 faculty, staff, graduates, family, and friends who filled the hall.

In his welcoming speech, Kenneth L. Davis, MD, President and Chief Executive Officer, Mount Sinai Health System, described the School of Medicine decades ago, when he joined its second class. “Fifty years ago, our political dialogue was consumed by the war in Vietnam. Today, health care is the center of our political debate,” he said. Health care makes up one-fifth of the nation’s economy, and its rising cost is forcing hard decisions on a critical question: “How do we ensure that we provide health care to everyone in this country?” Dr. Davis asked. “It is our job to bring to this debate the nuances and facts that we as physicians, academicians, and researchers see every day. I implore you to make sure the conversations we are having in our hospitals, in our communities, and across the country are honest and factual. Please help others recognize there are no simple solutions.”

New graduates, from front: Sarah Zarrin, MD; Anqi (Angela) Zheng, MD; and Hashem Emad Zikry, MD.

Dr. Gottlieb made a similar call to action. He has long been engaged in public policy—as a student and resident at Mount Sinai, he wrote articles on health care that appeared in journals and in newspapers, including The Wall Street Journal. He thanked the school’s leadership for giving him support and freedom in those days, and he challenged the Class of 2019 to take a stand on issues they believe in.

“I am proud of the foundation of service that this institution inspired me with,” Dr. Gottlieb told the graduates. “You all share those same traditions and will go on to do many more great things.” Dr. Gottlieb received an honorary Doctor of Science degree for his commitment to improving the nation’s health and for his work at the FDA, expediting the approval of treatments and drugs, and battling opioid addiction and the use of e-cigarettes by youth.

Honorary degrees were also awarded to:

Curtis Martin, a former New York Jets running back and a member of the National Football League Hall of Fame, who received an honorary Doctor of Humane Letters degree for creating the Curtis Martin Job Foundation to support causes such as low-income housing, scholarships for disadvantaged children, aid to people with disabilities, and surgical care in developing nations.

Helen H. Hobbs, MD, Investigator, Howard Hughes Medical Institute, and Professor of Internal Medicine, and Molecular Genetics, University of Texas Southwestern Medical Center, who received an honorary Doctor of Science degree for her influential research into the genetic determinants of cardiovascular disease and fatty liver disease, which has led to a highly effective therapy for reducing blood cholesterol levels.

C. Reynold Verret, PhD, President of Xavier University of Louisiana, who received an honorary Doctor of Science degree for developing innovative programs that are shaping the next generation of science, technology, engineering, and math (STEM) teachers for kindergarten through 12th grade, and mitigating a shortage of STEM educators, especially in underserved communities.

The graduates were congratulated by Richard A. Friedman, Co-Chairman of the Mount Sinai Health System Boards of Trustees, who said he was honored to take part in his first commencement in his new role. “You are beginning your medical careers during a time of transformation in how we leverage technology, investment, and biology to better understand human diseases and find new ways to conquer them,” Mr. Friedman said. “We look to all of you to take what you have learned at Mount Sinai and use it to help improve health care. We are in awe of you for having made the choice to dedicate your lives to this mission.”

The graduates were encouraged to “dare greatly” in their future careers by Dennis S. Charney, MD, Anne and Joel Ehrenkranz Dean, Icahn School of Medicine at Mount Sinai, and President for Academic Affairs, Mount Sinai Health System. He noted that they were already an accomplished group. They have published hundreds of peer-reviewed articles, and contributed to the study of immune deficiency and Alzheimer’s disease, and 38 took an extra “scholarly year” to enhance their training as physician-scientists. Dr. Charney said some graduates have shown great promise as entrepreneurs and have been strong advocates on issues including HIV/AIDS, global health, and racism and bias.

Still, Dr. Charney said, “There is much left to solve in medicine. You have studied all the diseases, memorized all the drugs, but how many of our treatments are truly curative?Very few.” Most surgical procedures are decades old, so innovation is badly needed, he said, and the digital age calls for new ways to prevent, monitor, and treat diseases. He also challenged the graduates to be in the forefront of the movement seeking equal health care for all. “What will it take for you, the Class of 2019, to accomplish these goals?” Dr. Charney asked. “You need to be heroes. You need to be not merely good, but great. And you need to change our world.”

Yonathan Debessai, MD, received his hood from his mother, Zaid Weldesellasie.

 

Robert Rifkin, MD, PhD—with his son, Aaron—was hooded by his father, Scott Rifkin, MD.

 

Connie Chen, MD, received her hood from her mother, Jenny Chen.

Mount Sinai Renames Department of Neuroscience

From left, Paul J. Kenny, PhD; Eric J. Nestler, MD, PhD; benefactors Pamela Nash, Helen Nash, Beth Nash, and Joshua Nash, member, Mount Sinai Boards of Trustees; and Richard A. Friedman, Co-Chairman, Boards of Trustees.

It has been a time of outstanding achievement for the Icahn School of Medicine at Mount Sinai’s Department of Neuroscience—worthy of a celebration.

On Wednesday, May 8, Mount Sinai leadership, benefactors, faculty, and staff attended a reception at the Hess Center for Science and Medicine to unveil the Department’s renaming to the Nash Family Department of Neuroscience, an event held to honor the Nash family for their philanthropic generosity and extraordinary commitment to brain research.

“The Nash family has been supporting critical initiatives at Mount Sinai for more than 40 years and began a focused commitment to advance our neuroscience community more than a decade ago,” says Eric J. Nestler, MD, PhD, Nash Family Professor of Neuroscience, Director of The Friedman Brain Institute, and Dean for Academic and Scientific Affairs at the Icahn School of Medicine at Mount Sinai. “The research that has been made possible through the family’s generosity is being translated into fundamentally new and improved treatments for some of the world’s most devastating brain disorders. We are forever grateful for their commitment to this important work.”

Richard A. Friedman with guests at the reception. A substantial gift from the Friedman family allowed for the creation of The Friedman Brain Institute.

As a direct result of the Nash family’s support, Mount Sinai’s neuroscience program has seen unprecedented growth. Over the past decade, more than 40 basic neuroscience faculty have been recruited to Mount Sinai. Today, the Neuroscience department is ranked No. 1 in the nation among U.S. medical schools in National Institutes of Health (NIH) funding.

“This is testament to the incredible research environment we have created at Mount Sinai with the support of the Nash family,” says Paul J. Kenny, PhD, the Ward-Coleman Professor and Chair of the Department, and Director of Mount Sinai’s Drug Discovery Institute, who has made significant contributions to furthering the understanding of the neurobiological mechanisms of drug addiction and obesity. “With their tremendous support, we have built the depth and breadth of scientific expertise that is required for us to have a real impact in many key areas of brain research. We are translationally focused, so our work is highly relevant to human health and central nervous system disorders. We are also a very close community and we support all of our colleagues, particularly our junior scientists. We foster an environment of research excellence but also one of collaboration and support. As a result, we are second to none when it comes to research funding and scientific impact.”

Helen S. Mayberg, MD, left, with Helen Nash

Groundbreaking work in deep brain stimulation is being conducted in the newly established Nash Family Center for Advanced Circuit Therapeutics, whose founding Director, Helen S. Mayberg, MD, Mount Sinai Professor in Neurotherapeutics, and Professor of Neuroscience, Neurology, Psychiatry, and Neurosurgery, is a pioneer in using brain circuit information to treat neuropsychiatric disorders. She is leading a team to harness the potential of deep brain stimulation—an innovative surgical procedure that has proven successful in treating movement disorders—to address a range of conditions that include depression, addiction, and schizophrenia.

“Additionally, we have researchers who have deep expertise in the mechanisms of gene regulation, and those with demonstrated ability to functionally dissect, manipulate, and understand brain circuitry in the context of complex behaviors,” Dr. Kenny says. “That is where research funding is increasingly directed, and we are on the cutting edge of neurocircuitry research.”

The goal now, Dr. Kenny adds, is to bring together the Department’s key strengths in brain circuitries and mechanisms of gene expression to drive new discoveries related to brain function and its role in disease. “Given the outstanding quality of research in our Department, and the level of NIH funding we have successfully competed for, I believe Mount Sinai is positioned to have a profound impact on human brain health.”

 

Eric J. Nestler, MD, PhD, welcomed guests and spoke about the strengths of the Nash Family Department of Neuroscience.