During the 2015 World Science Festival held recently in New York City, the Mount Sinai Health System sponsored a roundtable discussion titled, “Spotlight: Women in Science,” featuring four trailblazers from diverse disciplines, including Patricia Kovatch, Founding Associate Dean for Scientific Computing at Icahn School of Medicine at Mount Sinai. In a casual setting complete with cocktails and hors d’oeuvres, Ms. Kovatch and her three co-panelists—anthropologist Dean Falk, PhD; marine chemical biologist Mandë Holford, PhD; and space scientist Tara M. Ruttley, PhD—discussed their life’s work, what inspires them, and their triumphs and challenges.