With a lot of pain and no appointment, Paul O’Neill walked into the office of James Marion, MD, at The Mount Sinai Hospital. The visit would change his life, as Dr. Marion, Professor of Medicine and Gastroenterology at the Icahn School of Medicine at Mount Sinai and Director of Education and Outreach at the Susan and Leonard Feinstein Inflammatory Bowel Disease Clinical Center at The Mount Sinai Hospital, suggested a new medication, which turned out to be significantly better than the older medication he had been taking since he was diagnosed with Crohn’s disease as a teenager.